data_EZA
# 
_chem_comp.id                                    EZA 
_chem_comp.name                                  
"N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide" 
_chem_comp.type                                  NON-POLYMER 
_chem_comp.pdbx_type                             HETAIN 
_chem_comp.formula                               "C39 H52 F2 N6 O8" 
_chem_comp.mon_nstd_parent_comp_id               ? 
_chem_comp.pdbx_synonyms                         ? 
_chem_comp.pdbx_formal_charge                    0 
_chem_comp.pdbx_initial_date                     2018-02-15 
_chem_comp.pdbx_modified_date                    2018-05-11 
_chem_comp.pdbx_ambiguous_flag                   N 
_chem_comp.pdbx_release_status                   REL 
_chem_comp.pdbx_replaced_by                      ? 
_chem_comp.pdbx_replaces                         ? 
_chem_comp.formula_weight                        770.862 
_chem_comp.one_letter_code                       ? 
_chem_comp.three_letter_code                     EZA 
_chem_comp.pdbx_model_coordinates_details        ? 
_chem_comp.pdbx_model_coordinates_missing_flag   N 
_chem_comp.pdbx_ideal_coordinates_details        Corina 
_chem_comp.pdbx_ideal_coordinates_missing_flag   N 
_chem_comp.pdbx_model_coordinates_db_code        6CFD 
_chem_comp.pdbx_subcomponent_list                ? 
_chem_comp.pdbx_processing_site                  RCSB 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.alt_atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.charge 
_chem_comp_atom.pdbx_align 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_leaving_atom_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.model_Cartn_x 
_chem_comp_atom.model_Cartn_y 
_chem_comp_atom.model_Cartn_z 
_chem_comp_atom.pdbx_model_Cartn_x_ideal 
_chem_comp_atom.pdbx_model_Cartn_y_ideal 
_chem_comp_atom.pdbx_model_Cartn_z_ideal 
_chem_comp_atom.pdbx_component_atom_id 
_chem_comp_atom.pdbx_component_comp_id 
_chem_comp_atom.pdbx_ordinal 
EZA C8  C1  C 0 1 N N S -1.174 100.915 3.527  -2.775  -0.658 -0.304 C8  EZA 1   
EZA C5  C2  C 0 1 N N N -2.461 103.193 -0.674 -7.316  0.749  -1.329 C5  EZA 2   
EZA C6  C3  C 0 1 N N N -1.579 102.413 -0.012 -6.246  0.035  -1.668 C6  EZA 3   
EZA N6  N1  N 0 1 N N N -1.826 105.436 7.232  2.795   -2.831 -0.948 N6  EZA 4   
EZA N1  N2  N 0 1 N N N -0.944 101.211 2.174  -3.966  -0.673 -1.156 N1  EZA 5   
EZA C2  C4  C 0 1 N N N -2.015 105.539 -3.665 -11.003 0.308  -2.263 C2  EZA 6   
EZA N3  N3  N 0 1 N N N 2.775  103.606 2.485  2.674   3.360  -0.015 N3  EZA 7   
EZA C4  C5  C 0 1 N N N -2.249 103.533 -2.111 -8.541  0.733  -2.205 C4  EZA 8   
EZA C1  C6  C 0 1 N N N -3.291 105.256 -4.454 -12.220 -0.100 -1.431 C1  EZA 9   
EZA C3  C7  C 0 1 N N N -1.988 105.056 -2.214 -9.759  0.325  -1.373 C3  EZA 10  
EZA C7  C8  C 0 1 N N N -1.882 102.112 1.456  -5.050  0.050  -0.812 C7  EZA 11  
EZA O1  O1  O 0 1 N N N -2.875 102.589 1.985  -5.039  0.716  0.205  O1  EZA 12  
EZA C9  C9  C 0 1 N N N -0.434 99.671  4.041  -2.931  -1.694 0.811  C9  EZA 13  
EZA C10 C10 C 0 1 Y N N -1.155 98.443  3.561  -4.071  -1.294 1.712  C10 EZA 14  
EZA C11 C11 C 0 1 Y N N -2.280 97.945  4.212  -5.353  -1.732 1.440  C11 EZA 15  
EZA C12 C12 C 0 1 Y N N -2.945 96.822  3.709  -6.401  -1.365 2.267  C12 EZA 16  
EZA F1  F1  F 0 1 N N N -4.036 96.317  4.291  -7.655  -1.794 2.001  F1  EZA 17  
EZA C13 C13 C 0 1 Y N N -2.495 96.172  2.576  -6.165  -0.559 3.367  C13 EZA 18  
EZA C14 C14 C 0 1 Y N N -1.372 96.686  1.955  -4.880  -0.121 3.639  C14 EZA 19  
EZA F2  F2  F 0 1 N N N -0.955 96.088  0.882  -4.647  0.661  4.716  F2  EZA 20  
EZA C15 C15 C 0 1 Y N N -0.690 97.809  2.401  -3.833  -0.493 2.813  C15 EZA 21  
EZA C16 C16 C 0 1 N N N -0.684 102.141 4.275  -1.560  -0.991 -1.132 C16 EZA 22  
EZA O2  O2  O 0 1 N N N 0.387  102.125 4.868  -1.679  -1.219 -2.317 O2  EZA 23  
EZA N2  N4  N 0 1 N N N -1.534 103.353 4.266  -0.343  -1.036 -0.555 N2  EZA 24  
EZA C17 C17 C 0 1 N N S -1.110 104.521 4.962  0.838   -1.359 -1.360 C17 EZA 25  
EZA C18 C18 C 0 1 N N N -0.720 105.629 4.008  1.350   -0.091 -2.042 C18 EZA 26  
EZA O3  O3  O 0 1 N N N 0.475  105.293 3.284  1.509   0.966  -1.062 O3  EZA 27  
EZA C19 C19 C 0 1 N N N 1.807  105.337 3.886  1.040   2.185  -1.371 C19 EZA 28  
EZA O4  O4  O 0 1 N N N 2.022  105.724 5.013  0.453   2.367  -2.411 O4  EZA 29  
EZA C20 C20 C 0 1 N N S 2.751  104.925 2.989  1.260   3.329  -0.412 C20 EZA 30  
EZA C21 C21 C 0 1 N N N 3.031  105.869 1.946  0.950   4.665  -1.098 C21 EZA 31  
EZA C22 C22 C 0 1 N N R 2.235  105.191 0.855  2.313   5.307  -1.403 C22 EZA 32  
EZA C23 C23 C 0 1 N N N 2.599  105.692 -0.597 2.433   6.654  -0.688 C23 EZA 33  
EZA C24 C24 C 0 1 N N N 2.443  103.747 1.037  3.368   4.328  -0.866 C24 EZA 34  
EZA C25 C25 C 0 1 N N N 2.997  102.355 3.188  3.212   2.620  0.966  C25 EZA 35  
EZA O5  O5  O 0 1 N N N 2.954  101.305 2.567  2.487   1.902  1.628  O5  EZA 36  
EZA C26 C26 C 0 1 N N R 3.353  102.348 4.644  4.683   2.649  1.276  C26 EZA 37  
EZA C27 C27 C 0 1 N N N 4.584  101.596 4.934  4.957   3.658  2.395  C27 EZA 38  
EZA N4  N5  N 0 1 N N N 2.631  103.000 5.719  5.080   1.296  1.724  N4  EZA 39  
EZA C28 C28 C 0 1 N N N 3.306  103.748 6.802  5.786   0.515  0.870  C28 EZA 40  
EZA O6  O6  O 0 1 N N N 4.512  103.883 6.782  6.123   0.943  -0.213 O6  EZA 41  
EZA C29 C29 C 0 1 N N S 2.491  104.384 7.918  6.142   -0.889 1.293  C29 EZA 42  
EZA C30 C30 C 0 1 N N N 3.380  104.506 9.127  7.655   -1.070 1.347  C30 EZA 43  
EZA C31 C31 C 0 1 N N N 3.261  103.378 10.120 8.261   -1.016 -0.054 C31 EZA 44  
EZA C32 C32 C 0 1 N N N 2.900  102.120 9.477  7.634   -2.108 -0.928 C32 EZA 45  
EZA C33 C33 C 0 1 N N N 1.573  102.245 8.766  6.128   -1.840 -1.038 C33 EZA 46  
EZA N5  N6  N 0 1 N N N 1.363  103.617 8.277  5.569   -1.833 0.317  N5  EZA 47  
EZA C34 C34 C 0 1 N N N -0.070 104.072 8.197  4.585   -2.648 0.706  C34 EZA 48  
EZA O7  O7  O 0 1 N N N -0.921 103.252 8.521  4.313   -2.632 1.899  O7  EZA 49  
EZA C35 C35 C 0 1 N N S -0.465 105.424 7.751  3.764   -3.567 -0.135 C35 EZA 50  
EZA C36 C36 C 0 1 N N N -0.547 106.339 8.930  4.589   -4.472 -1.046 C36 EZA 51  
EZA C37 C37 C 0 1 N N N -1.906 106.945 8.911  4.130   -4.169 -2.481 C37 EZA 52  
EZA C38 C38 C 0 1 N N N -2.767 105.974 8.218  2.935   -3.216 -2.353 C38 EZA 53  
EZA C39 C39 C 0 1 N N N -2.217 105.015 5.880  1.904   -1.937 -0.469 C39 EZA 54  
EZA O8  O8  O 0 1 N N N -3.394 105.077 5.510  1.962   -1.597 0.695  O8  EZA 55  
EZA H1  H1  H 0 1 N N N -2.250 100.788 3.716  -2.655  0.333  0.135  H1  EZA 56  
EZA H2  H2  H 0 1 N N N -3.329 103.575 -0.157 -7.306  1.340  -0.425 H2  EZA 57  
EZA H3  H3  H 0 1 N N N -0.699 102.019 -0.498 -6.256  -0.557 -2.571 H3  EZA 58  
EZA H4  H4  H 0 1 N N N -0.157 100.819 1.698  -3.975  -1.205 -1.967 H4  EZA 59  
EZA H5  H5  H 0 1 N N N -1.181 105.055 -4.194 -10.861 -0.406 -3.073 H5  EZA 60  
EZA H6  H6  H 0 1 N N N -1.861 106.628 -3.657 -11.165 1.303  -2.680 H6  EZA 61  
EZA H7  H7  H 0 1 N N N -3.145 103.268 -2.692 -8.703  1.727  -2.622 H7  EZA 62  
EZA H8  H8  H 0 1 N N N -1.382 102.979 -2.501 -8.399  0.018  -3.016 H8  EZA 63  
EZA H9  H9  H 0 1 N N N -3.186 105.650 -5.476 -13.106 -0.112 -2.065 H9  EZA 64  
EZA H10 H10 H 0 1 N N N -3.463 104.170 -4.496 -12.058 -1.094 -1.014 H10 EZA 65  
EZA H11 H11 H 0 1 N N N -4.144 105.744 -3.959 -12.362 0.615  -0.620 H11 EZA 66  
EZA H12 H12 H 0 1 N N N -1.001 105.278 -1.783 -9.901  1.039  -0.562 H12 EZA 67  
EZA H13 H13 H 0 1 N N N -2.765 105.590 -1.646 -9.597  -0.670 -0.956 H13 EZA 68  
EZA H14 H14 H 0 1 N N N 0.596  99.669  3.656  -3.140  -2.670 0.373  H14 EZA 69  
EZA H15 H15 H 0 1 N N N -0.414 99.681  5.141  -2.010  -1.745 1.392  H15 EZA 70  
EZA H16 H16 H 0 1 N N N -2.641 98.427  5.108  -5.538  -2.362 0.582  H16 EZA 71  
EZA H17 H17 H 0 1 N N N -3.000 95.298  2.191  -6.981  -0.272 4.013  H17 EZA 72  
EZA H18 H18 H 0 1 N N N 0.173  98.183  1.870  -2.830  -0.152 3.025  H18 EZA 73  
EZA H19 H19 H 0 1 N N N -2.404 103.352 3.772  -0.248  -0.853 0.393  H19 EZA 74  
EZA H20 H20 H 0 1 N N N -0.235 104.278 5.582  0.563   -2.092 -2.120 H20 EZA 75  
EZA H21 H21 H 0 1 N N N -0.545 106.551 4.581  2.313   -0.297 -2.512 H21 EZA 76  
EZA H22 H22 H 0 1 N N N -1.539 105.792 3.293  0.637   0.219  -2.806 H22 EZA 77  
EZA H23 H23 H 0 1 N N N 3.676  104.962 3.583  0.631   3.206  0.469  H23 EZA 78  
EZA H24 H24 H 0 1 N N N 4.104  105.926 1.709  0.396   4.503  -2.020 H24 EZA 79  
EZA H25 H25 H 0 1 N N N 2.652  106.875 2.178  0.379   5.306  -0.425 H25 EZA 80  
EZA H26 H26 H 0 1 N N N 1.171  105.415 1.020  2.435   5.439  -2.477 H26 EZA 81  
EZA H27 H27 H 0 1 N N N 2.422  106.775 -0.667 3.417   7.081  -0.880 H27 EZA 82  
EZA H28 H28 H 0 1 N N N 3.658  105.480 -0.803 1.664   7.332  -1.058 H28 EZA 83  
EZA H29 H29 H 0 1 N N N 1.970  105.170 -1.333 2.304   6.509  0.385  H29 EZA 84  
EZA H30 H30 H 0 1 N N N 1.529  103.187 0.790  4.112   4.872  -0.286 H30 EZA 85  
EZA H31 H31 H 0 1 N N N 3.273  103.390 0.410  3.848   3.813  -1.698 H31 EZA 86  
EZA H32 H32 H 0 1 N N N 2.756  101.436 4.790  5.245   2.925  0.385  H32 EZA 87  
EZA H33 H33 H 0 1 N N N 4.789  101.629 6.014  4.406   3.366  3.289  H33 EZA 88  
EZA H34 H34 H 0 1 N N N 4.458  100.550 4.617  6.024   3.675  2.616  H34 EZA 89  
EZA H35 H35 H 0 1 N N N 5.426  102.046 4.387  4.635   4.649  2.077  H35 EZA 90  
EZA H36 H36 H 0 1 N N N 1.633  102.941 5.729  4.840   0.975  2.608  H36 EZA 91  
EZA H37 H37 H 0 1 N N N 2.182  105.390 7.600  5.711   -1.081 2.277  H37 EZA 92  
EZA H38 H38 H 0 1 N N N 4.423  104.548 8.781  8.090   -0.276 1.958  H38 EZA 93  
EZA H39 H39 H 0 1 N N N 3.127  105.444 9.643  7.887   -2.034 1.804  H39 EZA 94  
EZA H40 H40 H 0 1 N N N 4.227  103.251 10.631 8.082   -0.039 -0.500 H40 EZA 95  
EZA H41 H41 H 0 1 N N N 2.487  103.635 10.858 9.339   -1.185 0.013  H41 EZA 96  
EZA H42 H42 H 0 1 N N N 2.827  101.332 10.241 8.082   -2.087 -1.921 H42 EZA 97  
EZA H43 H43 H 0 1 N N N 3.677  101.852 8.746  7.798   -3.083 -0.471 H43 EZA 98  
EZA H44 H44 H 0 1 N N N 0.765  101.985 9.465  5.971   -0.863 -1.502 H44 EZA 99  
EZA H45 H45 H 0 1 N N N 1.556  101.552 7.912  5.660   -2.603 -1.646 H45 EZA 100 
EZA H46 H46 H 0 1 N N N 0.246  105.814 7.008  3.180   -4.225 0.543  H46 EZA 101 
EZA H47 H47 H 0 1 N N N -0.398 105.772 9.861  5.652   -4.275 -0.932 H47 EZA 102 
EZA H48 H48 H 0 1 N N N 0.219  107.125 8.853  4.386   -5.521 -0.811 H48 EZA 103 
EZA H49 H49 H 0 1 N N N -1.892 107.901 8.367  4.934   -3.693 -3.043 H49 EZA 104 
EZA H50 H50 H 0 1 N N N -2.265 107.112 9.937  3.824   -5.090 -2.979 H50 EZA 105 
EZA H51 H51 H 0 1 N N N -3.625 106.465 7.735  2.027   -3.721 -2.688 H51 EZA 106 
EZA H52 H52 H 0 1 N N N -3.129 105.192 8.902  3.104   -2.329 -2.965 H52 EZA 107 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
EZA C1  C2  SING N N 1   
EZA C2  C3  SING N N 2   
EZA C3  C4  SING N N 3   
EZA C4  C5  SING N N 4   
EZA C5  C6  DOUB N E 5   
EZA C23 C22 SING N N 6   
EZA C6  C7  SING N N 7   
EZA C22 C24 SING N N 8   
EZA C22 C21 SING N N 9   
EZA F2  C14 SING N N 10  
EZA C24 N3  SING N N 11  
EZA C7  O1  DOUB N N 12  
EZA C7  N1  SING N N 13  
EZA C21 C20 SING N N 14  
EZA C14 C15 DOUB Y N 15  
EZA C14 C13 SING Y N 16  
EZA N1  C8  SING N N 17  
EZA C15 C10 SING Y N 18  
EZA N3  C20 SING N N 19  
EZA N3  C25 SING N N 20  
EZA O5  C25 DOUB N N 21  
EZA C13 C12 DOUB Y N 22  
EZA C20 C19 SING N N 23  
EZA C25 C26 SING N N 24  
EZA O3  C19 SING N N 25  
EZA O3  C18 SING N N 26  
EZA C8  C9  SING N N 27  
EZA C8  C16 SING N N 28  
EZA C10 C9  SING N N 29  
EZA C10 C11 DOUB Y N 30  
EZA C12 C11 SING Y N 31  
EZA C12 F1  SING N N 32  
EZA C19 O4  DOUB N N 33  
EZA C18 C17 SING N N 34  
EZA N2  C16 SING N N 35  
EZA N2  C17 SING N N 36  
EZA C16 O2  DOUB N N 37  
EZA C26 C27 SING N N 38  
EZA C26 N4  SING N N 39  
EZA C17 C39 SING N N 40  
EZA O8  C39 DOUB N N 41  
EZA N4  C28 SING N N 42  
EZA C39 N6  SING N N 43  
EZA O6  C28 DOUB N N 44  
EZA C28 C29 SING N N 45  
EZA N6  C35 SING N N 46  
EZA N6  C38 SING N N 47  
EZA C35 C34 SING N N 48  
EZA C35 C36 SING N N 49  
EZA C29 N5  SING N N 50  
EZA C29 C30 SING N N 51  
EZA C34 N5  SING N N 52  
EZA C34 O7  DOUB N N 53  
EZA C38 C37 SING N N 54  
EZA N5  C33 SING N N 55  
EZA C33 C32 SING N N 56  
EZA C37 C36 SING N N 57  
EZA C30 C31 SING N N 58  
EZA C32 C31 SING N N 59  
EZA C8  H1  SING N N 60  
EZA C5  H2  SING N N 61  
EZA C6  H3  SING N N 62  
EZA N1  H4  SING N N 63  
EZA C2  H5  SING N N 64  
EZA C2  H6  SING N N 65  
EZA C4  H7  SING N N 66  
EZA C4  H8  SING N N 67  
EZA C1  H9  SING N N 68  
EZA C1  H10 SING N N 69  
EZA C1  H11 SING N N 70  
EZA C3  H12 SING N N 71  
EZA C3  H13 SING N N 72  
EZA C9  H14 SING N N 73  
EZA C9  H15 SING N N 74  
EZA C11 H16 SING N N 75  
EZA C13 H17 SING N N 76  
EZA C15 H18 SING N N 77  
EZA N2  H19 SING N N 78  
EZA C17 H20 SING N N 79  
EZA C18 H21 SING N N 80  
EZA C18 H22 SING N N 81  
EZA C20 H23 SING N N 82  
EZA C21 H24 SING N N 83  
EZA C21 H25 SING N N 84  
EZA C22 H26 SING N N 85  
EZA C23 H27 SING N N 86  
EZA C23 H28 SING N N 87  
EZA C23 H29 SING N N 88  
EZA C24 H30 SING N N 89  
EZA C24 H31 SING N N 90  
EZA C26 H32 SING N N 91  
EZA C27 H33 SING N N 92  
EZA C27 H34 SING N N 93  
EZA C27 H35 SING N N 94  
EZA N4  H36 SING N N 95  
EZA C29 H37 SING N N 96  
EZA C30 H38 SING N N 97  
EZA C30 H39 SING N N 98  
EZA C31 H40 SING N N 99  
EZA C31 H41 SING N N 100 
EZA C32 H42 SING N N 101 
EZA C32 H43 SING N N 102 
EZA C33 H44 SING N N 103 
EZA C33 H45 SING N N 104 
EZA C35 H46 SING N N 105 
EZA C36 H47 SING N N 106 
EZA C36 H48 SING N N 107 
EZA C37 H49 SING N N 108 
EZA C37 H50 SING N N 109 
EZA C38 H51 SING N N 110 
EZA C38 H52 SING N N 111 
# 
loop_
_pdbx_chem_comp_descriptor.comp_id 
_pdbx_chem_comp_descriptor.type 
_pdbx_chem_comp_descriptor.program 
_pdbx_chem_comp_descriptor.program_version 
_pdbx_chem_comp_descriptor.descriptor 
EZA SMILES           ACDLabs              12.01 "C(Cc1cc(F)cc(c1)F)(C(=O)NC2C(N5C(C(N4C(C(NC(C(N3C(C(OC2)=O)CC(C3)C)=O)C)=O)CCCC4)=O)CCC5)=O)NC(C=[C@H]CCCC)=O" 
EZA InChI            InChI                1.03  
;InChI=1S/C39H52F2N6O8/c1-4-5-6-7-13-33(48)43-28(19-25-17-26(40)20-27(41)18-25)34(49)44-29-22-55-39(54)32-16-23(2)21-47(32)36(51)24(3)42-35(50)30-11-8-9-14-45(30)38(53)31-12-10-15-46(31)37(29)52/h7,13,17-18,20,23-24,28-32H,4-6,8-12,14-16,19,21-22H2,1-3H3,(H,42,50)(H,43,48)(H,44,49)/b13-7+/t23-,24-,28+,29+,30+,31+,32+/m1/s1
;
EZA InChIKey         InChI                1.03  BAEUBYUDIYWBPI-AIRHAPKHSA-N 
EZA SMILES_CANONICAL CACTVS               3.385 "CCCC\C=C\C(=O)N[C@@H](Cc1cc(F)cc(F)c1)C(=O)N[C@H]2COC(=O)[C@@H]3C[C@@H](C)CN3C(=O)[C@@H](C)NC(=O)[C@@H]4CCCCN4C(=O)[C@@H]5CCCN5C2=O" 
EZA SMILES           CACTVS               3.385 "CCCCC=CC(=O)N[CH](Cc1cc(F)cc(F)c1)C(=O)N[CH]2COC(=O)[CH]3C[CH](C)CN3C(=O)[CH](C)NC(=O)[CH]4CCCCN4C(=O)[CH]5CCCN5C2=O" 
EZA SMILES_CANONICAL "OpenEye OEToolkits" 2.0.6 "CCCC/C=C/C(=O)N[C@@H](Cc1cc(cc(c1)F)F)C(=O)N[C@H]2COC(=O)[C@@H]3C[C@H](CN3C(=O)C(NC(=O)[C@@H]4CCCCN4C(=O)[C@@H]5CCCN5C2=O)C)C" 
EZA SMILES           "OpenEye OEToolkits" 2.0.6 "CCCCC=CC(=O)NC(Cc1cc(cc(c1)F)F)C(=O)NC2COC(=O)C3CC(CN3C(=O)C(NC(=O)C4CCCCN4C(=O)C5CCCN5C2=O)C)C" 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
EZA "SYSTEMATIC NAME" ACDLabs 12.01 
"N-[(6aS,12S,15aS,17R,21R,23aS)-17,21-dimethyl-6,11,15,20,23-pentaoxooctadecahydro-2H,6H,11H,15H-pyrido[2,1-i]dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13]oxatetraazacyclohexadecin-12-yl]-3,5-difluoro-Nalpha-[(2E)-hept-2-enoyl]-L-phenylalaninamide" 
# 
loop_
_pdbx_chem_comp_audit.comp_id 
_pdbx_chem_comp_audit.action_type 
_pdbx_chem_comp_audit.date 
_pdbx_chem_comp_audit.processing_site 
EZA "Create component" 2018-02-15 RCSB 
EZA "Initial release"  2018-05-16 RCSB 
# 
