data_DE6
#

_chem_comp.id                                   DE6
_chem_comp.name                                 "1-[(5~{S},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-5-methyl-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine"
_chem_comp.type                                 NON-POLYMER
_chem_comp.pdbx_type                            HETAIN
_chem_comp.formula                              "C31 H52 N10 O5"
_chem_comp.mon_nstd_parent_comp_id              ?
_chem_comp.pdbx_synonyms                        ?
_chem_comp.pdbx_formal_charge                   0
_chem_comp.pdbx_initial_date                    2019-07-30
_chem_comp.pdbx_modified_date                   2020-06-12
_chem_comp.pdbx_ambiguous_flag                  N
_chem_comp.pdbx_release_status                  REL
_chem_comp.pdbx_replaced_by                     ?
_chem_comp.pdbx_replaces                        ?
_chem_comp.formula_weight                       644.809
_chem_comp.one_letter_code                      ?
_chem_comp.three_letter_code                    DE6
_chem_comp.pdbx_model_coordinates_details       ?
_chem_comp.pdbx_model_coordinates_missing_flag  N
_chem_comp.pdbx_ideal_coordinates_details       Corina
_chem_comp.pdbx_ideal_coordinates_missing_flag  N
_chem_comp.pdbx_model_coordinates_db_code       6KK5
_chem_comp.pdbx_subcomponent_list               ?
_chem_comp.pdbx_processing_site                 PDBJ
#   #
loop_
_chem_comp_atom.comp_id
_chem_comp_atom.atom_id
_chem_comp_atom.alt_atom_id
_chem_comp_atom.type_symbol
_chem_comp_atom.charge
_chem_comp_atom.pdbx_align
_chem_comp_atom.pdbx_aromatic_flag
_chem_comp_atom.pdbx_leaving_atom_flag
_chem_comp_atom.pdbx_stereo_config
_chem_comp_atom.model_Cartn_x
_chem_comp_atom.model_Cartn_y
_chem_comp_atom.model_Cartn_z
_chem_comp_atom.pdbx_model_Cartn_x_ideal
_chem_comp_atom.pdbx_model_Cartn_y_ideal
_chem_comp_atom.pdbx_model_Cartn_z_ideal
_chem_comp_atom.pdbx_component_atom_id
_chem_comp_atom.pdbx_component_comp_id
_chem_comp_atom.pdbx_ordinal
DE6  C10  C1   C  0  1  N  N  R   -5.444   6.032  -18.764    3.654   3.451  -0.785  C10  DE6   1  
DE6  C15  C2   C  0  1  N  N  N   -6.892   5.681  -19.089    2.205   3.488  -1.277  C15  DE6   2  
DE6  C17  C3   C  0  1  N  N  N   -9.122   5.231  -18.136   -0.063   3.093  -0.308  C17  DE6   3  
DE6  C20  C4   C  0  1  N  N  N   -8.963   5.821  -14.767   -2.499   2.123  -0.540  C20  DE6   4  
DE6  C22  C5   C  0  1  N  N  S   -8.442   5.177  -13.489   -3.727   1.351  -0.949  C22  DE6   5  
DE6  C24  C6   C  0  1  N  N  N   -8.063   5.310  -11.051   -6.225   1.377  -1.002  C24  DE6   6  
DE6  C26  C7   C  0  1  N  N  N   -8.035   3.387   -9.475   -8.723   1.402  -1.055  C26  DE6   7  
DE6  C01  C8   C  0  1  Y  N  N    0.124   7.573  -17.240    3.427  -5.586   0.309  C01  DE6   8  
DE6  C02  C9   C  0  1  Y  N  N   -0.986   8.400  -17.166    3.296  -4.474  -0.501  C02  DE6   9  
DE6  C03  C10  C  0  1  N  N  N   -1.136   9.591  -18.110    4.466  -3.544  -0.699  C03  DE6  10  
DE6  C05  C11  C  0  1  N  N  N   -3.552  10.106  -18.593    4.900  -1.208  -0.267  C05  DE6  11  
DE6  C06  C12  C  0  1  N  N  S   -4.802   9.853  -19.433    4.738   0.051   0.544  C06  DE6  12  
DE6  C07  C13  C  0  1  N  N  N   -6.051  10.555  -18.906    3.491  -0.062   1.423  C07  DE6  13  
DE6  C09  C14  C  0  1  N  N  N   -5.235   7.524  -18.490    3.853   2.244   0.096  C09  DE6  14  
DE6  C12  C15  C  0  1  N  N  N   -3.188   5.443  -19.747    5.235   5.122   0.086  C12  DE6  15  
DE6  C16  C16  C  0  1  N  N  N   -7.801   5.955  -17.900    1.276   3.804  -0.102  C16  DE6  16  
DE6  C18  C17  C  0  1  N  N  N  -10.080   5.575  -17.002   -1.179   4.132  -0.423  C18  DE6  17  
DE6  C23  C18  C  0  1  N  N  N   -8.823   5.933  -12.221   -4.979   2.095  -0.479  C23  DE6  18  
DE6  C25  C19  C  0  1  N  N  N   -8.896   4.178  -10.455   -7.477   2.120  -0.533  C25  DE6  19  
DE6  C29  C20  C  0  1  N  N  N   -6.465   3.668  -13.821   -3.028  -0.959  -1.013  C29  DE6  20  
DE6  C31  C21  C  0  1  N  N  S   -4.955   3.452  -13.821   -2.944  -2.343  -0.423  C31  DE6  21  
DE6  C32  C22  C  0  1  N  N  N   -4.632   2.513  -12.657   -2.244  -2.281   0.936  C32  DE6  22  
DE6  C33  C23  C  0  1  N  N  N   -3.131   2.379  -12.414   -2.970  -1.281   1.839  C33  DE6  23  
DE6  C34  C24  C  0  1  N  N  N   -2.941   1.614  -11.102   -2.372  -1.337   3.246  C34  DE6  24  
DE6  C35  C25  C  0  1  N  N  N   -1.494   1.143  -10.971   -3.099  -0.337   4.148  C35  DE6  25  
DE6  C38  C26  C  0  1  N  N  N   -3.664   5.473  -14.682   -1.130  -3.887  -0.772  C38  DE6  26  
DE6  C40  C27  C  0  1  N  N  N   -2.968   6.793  -14.353   -0.289  -4.787  -1.640  C40  DE6  27  
DE6  C41  C28  C  0  1  Y  N  N   -1.865   7.064  -15.374    1.021  -5.069  -0.952  C41  DE6  28  
DE6  C42  C29  C  0  1  Y  N  N   -1.980   8.141  -16.237    2.094  -4.215  -1.132  C42  DE6  29  
DE6  C43  C30  C  0  1  Y  N  N   -0.755   6.239  -15.444    1.151  -6.180  -0.140  C43  DE6  30  
DE6  C44  C31  C  0  1  Y  N  N    0.240   6.493  -16.377    2.354  -6.439   0.490  C44  DE6  31  
DE6  N04  N1   N  0  1  N  N  N   -2.335   9.377  -18.898    4.267  -2.343   0.137  N04  DE6  32  
DE6  N08  N2   N  0  1  N  N  N   -5.011   8.424  -19.611    4.590   1.197  -0.382  N08  DE6  33  
DE6  N11  N3   N  0  1  N  N  N   -4.624   5.588  -19.876    3.942   4.666  -0.020  N11  DE6  34  
DE6  N13  N4   N  0  1  N  N  N   -2.616   5.704  -18.663    5.505   6.263   0.804  N13  DE6  35  
DE6  N14  N5   N  0  1  N  N  N   -2.418   4.992  -20.892    6.204   4.471  -0.494  N14  DE6  36  
DE6  N19  N6   N  0  1  N  N  N   -9.580   4.983  -15.776   -2.418   3.449  -0.860  N19  DE6  37  
DE6  N27  N7   N  0  1  N  N  N   -8.843   2.392   -8.792   -9.925   2.116  -0.605  N27  DE6  38  
DE6  N28  N8   N  0  1  N  N  N   -7.006   4.978  -13.516   -3.681   0.015  -0.322  N28  DE6  39  
DE6  N36  N9   N  0  1  N  N  N   -1.193   0.913   -9.566   -2.524  -0.390   5.499  N36  DE6  40  
DE6  N37  N10  N  0  1  N  N  N   -4.276   4.718  -13.599   -2.165  -3.203  -1.344  N37  DE6  41  
DE6  O21  O1   O  0  1  N  N  N   -8.865   6.990  -14.937   -1.598   1.577   0.062  O21  DE6  42  
DE6  O30  O2   O  0  1  N  N  N   -7.196   2.763  -14.050   -2.522  -0.717  -2.088  O30  DE6  43  
DE6  O39  O3   O  0  1  N  N  N   -3.700   5.079  -15.802   -0.893  -3.773   0.412  O39  DE6  44  
DE6  O45  O4   O  0  1  N  N  N   -5.258   7.934  -17.376    3.370   2.203   1.207  O45  DE6  45  
DE6  O46  O5   O  0  1  N  N  N   -3.575  10.888  -17.703    5.587  -1.211  -1.267  O46  DE6  46  
DE6  H1   H1   H  0  1  N  N  N   -5.153   5.477  -17.860    4.326   3.391  -1.640  H1   DE6  47  
DE6  H2   H2   H  0  1  N  N  N   -7.226   6.287  -19.944    2.101   4.259  -2.040  H2   DE6  48  
DE6  H3   H3   H  0  1  N  N  N   -6.953   4.614  -19.350    1.940   2.520  -1.700  H3   DE6  49  
DE6  H4   H4   H  0  1  N  N  N   -9.554   5.553  -19.095   -0.023   2.500  -1.222  H4   DE6  50  
DE6  H5   H5   H  0  1  N  N  N   -8.950   4.145  -18.158   -0.261   2.439   0.541  H5   DE6  51  
DE6  H6   H6   H  0  1  N  N  N   -8.914   4.186  -13.419   -3.749   1.247  -2.033  H6   DE6  52  
DE6  H7   H7   H  0  1  N  N  N   -7.102   4.911  -11.408   -6.202   1.355  -2.092  H7   DE6  53  
DE6  H8   H8   H  0  1  N  N  N   -7.880   6.075  -10.283   -6.243   0.356  -0.619  H8   DE6  54  
DE6  H9   H9   H  0  1  N  N  N   -7.226   2.884  -10.025   -8.700   1.380  -2.145  H9   DE6  55  
DE6  H10  H10  H  0  1  N  N  N   -7.602   4.075   -8.734   -8.741   0.381  -0.672  H10  DE6  56  
DE6  H11  H11  H  0  1  N  N  N    0.897   7.769  -17.968    4.366  -5.788   0.802  H11  DE6  57  
DE6  H12  H12  H  0  1  N  N  N   -0.260   9.658  -18.771    5.386  -4.047  -0.402  H12  DE6  58  
DE6  H13  H13  H  0  1  N  N  N   -1.230  10.521  -17.529    4.528  -3.253  -1.747  H13  DE6  59  
DE6  H14  H14  H  0  1  N  N  N   -4.601  10.280  -20.427    5.616   0.200   1.172  H14  DE6  60  
DE6  H15  H15  H  0  1  N  N  N   -5.846  11.629  -18.788    3.446  -1.058   1.864  H15  DE6  61  
DE6  H16  H16  H  0  1  N  N  N   -6.878  10.416  -19.618    3.536   0.684   2.216  H16  DE6  62  
DE6  H17  H17  H  0  1  N  N  N   -6.330  10.126  -17.932    2.601   0.106   0.816  H17  DE6  63  
DE6  H18  H18  H  0  1  N  N  N   -7.331   5.582  -16.978    1.733   3.458   0.825  H18  DE6  64  
DE6  H19  H19  H  0  1  N  N  N   -7.980   7.037  -17.809    1.112   4.880  -0.048  H19  DE6  65  
DE6  H20  H20  H  0  1  N  N  N  -10.141   6.667  -16.888   -1.344   4.602   0.547  H20  DE6  66  
DE6  H21  H21  H  0  1  N  N  N  -11.079   5.173  -17.227   -0.901   4.889  -1.156  H21  DE6  67  
DE6  H22  H22  H  0  1  N  N  N   -8.548   6.993  -12.322   -5.002   2.116   0.610  H22  DE6  68  
DE6  H23  H23  H  0  1  N  N  N   -9.906   5.850  -12.049   -4.961   3.115  -0.863  H23  DE6  69  
DE6  H24  H24  H  0  1  N  N  N   -9.764   4.598   -9.926   -7.500   2.141   0.557  H24  DE6  70  
DE6  H25  H25  H  0  1  N  N  N   -9.243   3.513  -11.260   -7.458   3.140  -0.916  H25  DE6  71  
DE6  H26  H26  H  0  1  N  N  N   -4.640   2.995  -14.771   -3.947  -2.751  -0.302  H26  DE6  72  
DE6  H27  H27  H  0  1  N  N  N   -5.103   2.907  -11.745   -2.260  -3.267   1.399  H27  DE6  73  
DE6  H28  H28  H  0  1  N  N  N   -5.043   1.518  -12.882   -1.211  -1.961   0.798  H28  DE6  74  
DE6  H29  H29  H  0  1  N  N  N   -2.665   1.825  -13.242   -2.855  -0.276   1.434  H29  DE6  75  
DE6  H30  H30  H  0  1  N  N  N   -2.673   3.376  -12.336   -4.029  -1.536   1.884  H30  DE6  76  
DE6  H31  H31  H  0  1  N  N  N   -3.186   2.275  -10.257   -2.487  -2.342   3.651  H31  DE6  77  
DE6  H32  H32  H  0  1  N  N  N   -3.610   0.741  -11.090   -1.313  -1.082   3.201  H32  DE6  78  
DE6  H33  H33  H  0  1  N  N  N   -1.359   0.208  -11.534   -2.983   0.668   3.743  H33  DE6  79  
DE6  H34  H34  H  0  1  N  N  N   -0.818   1.913  -11.371   -4.157  -0.591   4.193  H34  DE6  80  
DE6  H35  H35  H  0  1  N  N  N   -2.528   6.733  -13.347   -0.818  -5.724  -1.811  H35  DE6  81  
DE6  H36  H36  H  0  1  N  N  N   -3.703   7.611  -14.383   -0.100  -4.297  -2.595  H36  DE6  82  
DE6  H37  H37  H  0  1  N  N  N   -2.848   8.781  -16.185    1.992  -3.347  -1.765  H37  DE6  83  
DE6  H38  H38  H  0  1  N  N  N   -0.664   5.398  -14.773    0.313  -6.846   0.001  H38  DE6  84  
DE6  H39  H39  H  0  1  N  N  N    1.106   5.849  -16.431    2.455  -7.308   1.123  H39  DE6  85  
DE6  H40  H40  H  0  1  N  N  N   -2.323   8.724  -19.655    3.712  -2.362   0.932  H40  DE6  86  
DE6  H41  H41  H  0  1  N  N  N   -5.000   8.047  -20.537    4.988   1.204  -1.266  H41  DE6  87  
DE6  H42  H42  H  0  1  N  N  N   -5.060   5.377  -20.751    3.220   5.150   0.412  H42  DE6  88  
DE6  H43  H43  H  0  1  N  N  N   -3.151   6.015  -17.878    4.784   6.747   1.235  H43  DE6  89  
DE6  H44  H44  H  0  1  N  N  N   -1.625   5.601  -18.583    6.417   6.584   0.878  H44  DE6  90  
DE6  H45  H45  H  0  1  N  N  N   -1.441   4.931  -20.686    7.116   4.793  -0.419  H45  DE6  91  
DE6  H46  H46  H  0  1  N  N  N   -9.661   3.997  -15.627   -3.124   3.910  -1.341  H46  DE6  92  
DE6  H47  H47  H  0  1  N  N  N   -8.271   1.879   -8.152  -10.762   1.660  -0.937  H47  DE6  93  
DE6  H48  H48  H  0  1  N  N  N   -9.578   2.847   -8.290   -9.937   2.205   0.400  H48  DE6  94  
DE6  H50  H50  H  0  1  N  N  N   -6.390   5.742  -13.325   -4.095  -0.159   0.538  H50  DE6  95  
DE6  H51  H51  H  0  1  N  N  N   -0.246   0.604   -9.474   -1.530  -0.221   5.476  H51  DE6  96  
DE6  H52  H52  H  0  1  N  N  N   -1.317   1.764   -9.055   -2.988   0.262   6.115  H52  DE6  97  
DE6  H54  H54  H  0  1  N  N  N   -4.228   5.083  -12.669   -2.375  -3.275  -2.288  H54  DE6  98  
#   #
loop_
_chem_comp_bond.comp_id
_chem_comp_bond.atom_id_1
_chem_comp_bond.atom_id_2
_chem_comp_bond.value_order
_chem_comp_bond.pdbx_aromatic_flag
_chem_comp_bond.pdbx_stereo_config
_chem_comp_bond.pdbx_ordinal
DE6  N14  C12  DOUB  N  N   1  
DE6  N11  C12  SING  N  N   2  
DE6  N11  C10  SING  N  N   3  
DE6  C12  N13  SING  N  N   4  
DE6  N08  C06  SING  N  N   5  
DE6  N08  C09  SING  N  N   6  
DE6  C06  C07  SING  N  N   7  
DE6  C06  C05  SING  N  N   8  
DE6  C15  C10  SING  N  N   9  
DE6  C15  C16  SING  N  N  10  
DE6  N04  C05  SING  N  N  11  
DE6  N04  C03  SING  N  N  12  
DE6  C10  C09  SING  N  N  13  
DE6  C05  O46  DOUB  N  N  14  
DE6  C09  O45  DOUB  N  N  15  
DE6  C17  C16  SING  N  N  16  
DE6  C17  C18  SING  N  N  17  
DE6  C03  C02  SING  N  N  18  
DE6  C01  C02  DOUB  Y  N  19  
DE6  C01  C44  SING  Y  N  20  
DE6  C02  C42  SING  Y  N  21  
DE6  C18  N19  SING  N  N  22  
DE6  C44  C43  DOUB  Y  N  23  
DE6  C42  C41  DOUB  Y  N  24  
DE6  O39  C38  DOUB  N  N  25  
DE6  N19  C20  SING  N  N  26  
DE6  C43  C41  SING  Y  N  27  
DE6  C41  C40  SING  N  N  28  
DE6  O21  C20  DOUB  N  N  29  
DE6  C20  C22  SING  N  N  30  
DE6  C38  C40  SING  N  N  31  
DE6  C38  N37  SING  N  N  32  
DE6  O30  C29  DOUB  N  N  33  
DE6  C29  C31  SING  N  N  34  
DE6  C29  N28  SING  N  N  35  
DE6  C31  N37  SING  N  N  36  
DE6  C31  C32  SING  N  N  37  
DE6  N28  C22  SING  N  N  38  
DE6  C22  C23  SING  N  N  39  
DE6  C32  C33  SING  N  N  40  
DE6  C33  C34  SING  N  N  41  
DE6  C23  C24  SING  N  N  42  
DE6  C34  C35  SING  N  N  43  
DE6  C24  C25  SING  N  N  44  
DE6  C35  N36  SING  N  N  45  
DE6  C25  C26  SING  N  N  46  
DE6  C26  N27  SING  N  N  47  
DE6  C10  H1   SING  N  N  48  
DE6  C15  H2   SING  N  N  49  
DE6  C15  H3   SING  N  N  50  
DE6  C17  H4   SING  N  N  51  
DE6  C17  H5   SING  N  N  52  
DE6  C22  H6   SING  N  N  53  
DE6  C24  H7   SING  N  N  54  
DE6  C24  H8   SING  N  N  55  
DE6  C26  H9   SING  N  N  56  
DE6  C26  H10  SING  N  N  57  
DE6  C01  H11  SING  N  N  58  
DE6  C03  H12  SING  N  N  59  
DE6  C03  H13  SING  N  N  60  
DE6  C06  H14  SING  N  N  61  
DE6  C07  H15  SING  N  N  62  
DE6  C07  H16  SING  N  N  63  
DE6  C07  H17  SING  N  N  64  
DE6  C16  H18  SING  N  N  65  
DE6  C16  H19  SING  N  N  66  
DE6  C18  H20  SING  N  N  67  
DE6  C18  H21  SING  N  N  68  
DE6  C23  H22  SING  N  N  69  
DE6  C23  H23  SING  N  N  70  
DE6  C25  H24  SING  N  N  71  
DE6  C25  H25  SING  N  N  72  
DE6  C31  H26  SING  N  N  73  
DE6  C32  H27  SING  N  N  74  
DE6  C32  H28  SING  N  N  75  
DE6  C33  H29  SING  N  N  76  
DE6  C33  H30  SING  N  N  77  
DE6  C34  H31  SING  N  N  78  
DE6  C34  H32  SING  N  N  79  
DE6  C35  H33  SING  N  N  80  
DE6  C35  H34  SING  N  N  81  
DE6  C40  H35  SING  N  N  82  
DE6  C40  H36  SING  N  N  83  
DE6  C42  H37  SING  N  N  84  
DE6  C43  H38  SING  N  N  85  
DE6  C44  H39  SING  N  N  86  
DE6  N04  H40  SING  N  N  87  
DE6  N08  H41  SING  N  N  88  
DE6  N11  H42  SING  N  N  89  
DE6  N13  H43  SING  N  N  90  
DE6  N13  H44  SING  N  N  91  
DE6  N14  H45  SING  N  N  92  
DE6  N19  H46  SING  N  N  93  
DE6  N27  H47  SING  N  N  94  
DE6  N27  H48  SING  N  N  95  
DE6  N28  H50  SING  N  N  96  
DE6  N36  H51  SING  N  N  97  
DE6  N36  H52  SING  N  N  98  
DE6  N37  H54  SING  N  N  99  
#   #
loop_
_pdbx_chem_comp_descriptor.comp_id
_pdbx_chem_comp_descriptor.type
_pdbx_chem_comp_descriptor.program
_pdbx_chem_comp_descriptor.program_version
_pdbx_chem_comp_descriptor.descriptor
DE6  InChI             InChI                 1.03   "InChI=1S/C31H52N10O5/c1-20-27(43)37-19-22-10-8-9-21(17-22)18-26(42)39-24(12-3-6-15-33)30(46)40-23(11-2-5-14-32)28(44)36-16-7-4-13-25(29(45)38-20)41-31(34)35/h8-10,17,20,23-25H,2-7,11-16,18-19,32-33H2,1H3,(H,36,44)(H,37,43)(H,38,45)(H,39,42)(H,40,46)(H4,34,35,41)/t20-,23-,24-,25+/m0/s1"  
DE6  InChIKey          InChI                 1.03   WUGZEUIQIOXIIV-WAABAYLZSA-N  
DE6  SMILES_CANONICAL  CACTVS                3.385  "C[C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)Cc2cccc(CNC1=O)c2)NC(N)=N"  
DE6  SMILES            CACTVS                3.385  "C[CH]1NC(=O)[CH](CCCCNC(=O)[CH](CCCCN)NC(=O)[CH](CCCCN)NC(=O)Cc2cccc(CNC1=O)c2)NC(N)=N"  
DE6  SMILES_CANONICAL  "OpenEye OEToolkits"  2.0.7  "[H]/N=C(/N)\N[C@@H]1CCCCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)Cc2cccc(c2)CNC(=O)[C@@H](NC1=O)C)CCCCN)CCCCN"  
DE6  SMILES            "OpenEye OEToolkits"  2.0.7  "CC1C(=O)NCc2cccc(c2)CC(=O)NC(C(=O)NC(C(=O)NCCCCC(C(=O)N1)NC(=N)N)CCCCN)CCCCN"  
#
_pdbx_chem_comp_identifier.comp_id          DE6
_pdbx_chem_comp_identifier.type             "SYSTEMATIC NAME"
_pdbx_chem_comp_identifier.program          "OpenEye OEToolkits"
_pdbx_chem_comp_identifier.program_version  2.0.7
_pdbx_chem_comp_identifier.identifier       "1-[(5~{S},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-5-methyl-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine"
#   #
loop_
_pdbx_chem_comp_audit.comp_id
_pdbx_chem_comp_audit.action_type
_pdbx_chem_comp_audit.date
_pdbx_chem_comp_audit.processing_site
DE6  "Create component"  2019-07-30  PDBJ  
DE6  "Initial release"   2020-06-17  RCSB  
##
