data_FAM_000189
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000189
_pdbx_reference_molecule_family.name            "Phe-hydroxyethylene-isostere-based protease inhibitors"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000189   PRD_000319  
FAM_000189   PRD_000320  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000189   PRD_000319   1     PDB          "SKF 108738"
FAM_000189   PRD_000319   2     Scifinder    "L-Valine, N-[N-[5-[(N-L-alanyl-L-alanyl)amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-valyl]-, methyl ester, [2S-(2R*,4R*,5R*)]-"
FAM_000189   PRD_000319   3     SciFinder    "SKF 108738"
FAM_000189   PRD_000319   4     PubChem      Skf-108738
FAM_000189   PRD_000319   5     ChemSpider   "L-Valine, N-(N-(N-(2-((N-L-alanyl-L-alanyl)amino)-1-hydroxy-3-phenylprop yl)-L-phenylalanyl)-L-valyl)-, methyl ester, (S-(R*,R*))-"
FAM_000189   PRD_000320   6     PDB          "SKF 107457"
FAM_000189   PRD_000320   7     PDB          "(2S,5S,8R,10S,11S,14R,17R)-8,17-diamino-11-benzyl-10-hydroxy-2-[(1S)-3-hydroxy-1-methylpropyl]-14-methyl-5-(1-methylethyl)-4,7,13,16-tetraoxo-3,6,12,15-tetraazaoctadecan-1-oic acid"
FAM_000189   PRD_000320   8     PubChem      "5-(Ala-Ala) Val-Val-OMe deriv."
FAM_000189   PRD_000320   9     PubChem      Ala-Ala-Phepsi(CH(OH)CH2)Gly-Val-Val-OCH3
FAM_000189   PRD_000320   10    PubChem      "Hydroxyethylene isostere analog(AA-II-VV-OMe)"
FAM_000189   PRD_000320   11    PubChem      Ala-Ala-Phe.psi.[CH(OH)CH2]Gly-Val-Val-OCH3
FAM_000189   PRD_000320   12    PubChem      ALA-ALA-PHE-PSI((S)-CHOH-CH2)-GLY-VAL-VAL-OME
FAM_000189   PRD_000320   13    PubChem      "5-(L-Alanyl-L-alanylamino)-4-hydroxy-6-phenylhexanoic acid, methyl valyl-valyl amide"
FAM_000189   PRD_000320   14    PubChem      "(S)-2-((S)-2-{(4S,5S)-5-[(S)-2-((S)-2-Amino-propionylamino)-propionylamino]-4-hydroxy-6-phenyl-hexanoylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester"
FAM_000189   PRD_000320   15    PubChem      "2-(2-{5-[2-(2-AMINO-PROPIONYLAMINO)-PROPIONYLAMINO]-4-HYDROXY-6-PHENYL-HEXANOYLAMINO}-3-METHYL-BUTYRYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER"
FAM_000189   PRD_000320   16    PubChem      "L-Valine, L-alanyl-L-alanyl-(.gamma.S, .delta.S)-.delta.-amino-.gamma.-hydroxybenzenehexanoyl-L-valyl-, methyl ester"
FAM_000189   PRD_000320   17    PubChem      "L-Valine, L-alanyl-L-alanyl-(gammaS, deltaS)-delta-amino-gamma-hydroxybenzenehexanoyl-L-valyl-, methyl ester"
FAM_000189   PRD_000320   18    PubChem      "methyl (2S)-2-[[(2S)-2-[[(4S,5S)-5-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-4-hydroxy-6-phenylhexanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoate"
FAM_000189   PRD_000320   19    PubChem      "C-terminal inhibitor 1"
FAM_000189   PRD_000320   20    SciFinder    "SKF 107457"
FAM_000189   PRD_000320   21    SciFinder    "SKB Va"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000189   PRD_000319   1     PMID:1429626         Function                  "hydroxyethylene-based inhibitor of human immunodeficiency virus type 1 protease"
FAM_000189   PRD_000320   2     PMID:1429626         Function                  "hydroxyethylene-based inhibitor of human immunodeficiency virus type 1 protease"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000189   PRD_000319   1     1     PubChem                External_reference_ID     446057
FAM_000189   PRD_000319   2     1     ChemSpider             External_reference_ID     393514
FAM_000189   PRD_000319   3     2     ChemSpider             External_reference_ID     8207971
FAM_000189   PRD_000319   4     1     CAS                    External_reference_ID     144285-78-9
FAM_000189   PRD_000319   5     2     PubChem                External_reference_ID     73194
FAM_000189   PRD_000319   6     3     ChemSpider             External_reference_ID     65955
FAM_000189   PRD_000319   7     1     ChemIDplus             External_reference_ID     144285789
FAM_000189   PRD_000319   8     1     MESH                   External_reference_ID     C077944
FAM_000189   PRD_000320   9     1     PubChem                External_Reference_ID     444196
FAM_000189   PRD_000320   10    1     DrugBank               External_Reference_ID     DB04191
FAM_000189   PRD_000320   11    1     CAS                    External_Reference_ID     126333-28-6
FAM_000189   PRD_000320   12    1     ChEMBL                 External_Reference_ID     49004
FAM_000189   PRD_000320   13    1     ChEBI                  External_Reference_ID     176626
FAM_000189   PRD_000320   14    1     BindingDB              External_Reference_ID     903
FAM_000189   PRD_000320   15    1     ChemSpider             External_Reference_ID     392186
FAM_000189   PRD_000320   16    1     ChemIDplus             External_Reference_ID     126333286
#
_citation.id                       1
_citation.year                     1993
_citation.journal_volume           62
_citation.page_first               543
_citation.page_last                585
_citation.pdbx_database_id_DOI     10.1146/annurev.bi.62.070193.002551
_citation.pdbx_database_id_PubMed  8352596
_citation.title                    "Structure-Based Inhibitors of HIV-1 Protease"
_citation.journal_abbrev           "Annual Review of Biochemistry"
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
1  1  "Wlodawer, A."  
1  2  "Erickson, J.W."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000189	2012-02-08	RCSB	"Create family"	
FAM_000189	2013-10-16	RCSB	"Initial release"	
#
