data_FAM_000089
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000089
_pdbx_reference_molecule_family.name            LEUPEPTIN
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000089   PRD_000216  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000089   PRD_000216   1     PDB          "N-acetyl(N-propionyl)-L-leucyl-L-leucyl-D L-argininal"
FAM_000089   PRD_000216   2     PubChem      "Leupeptin, Hemisulfate"
FAM_000089   PRD_000216   3     PubChem      Ac-LLR-CHO
FAM_000089   PRD_000216   4     PubChem      "2-Acetylamino-4-methyl-pentanoic acid [1-(1-formyl-4-guanidino-butylcarbamoyl)-3-methyl-butyl]-amide"
FAM_000089   PRD_000216   5     PubChem      2-acetamido-N-[1-[[5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-4-methylpentanamide
FAM_000089   PRD_000216   6     PubChem      2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methylvaleramide
FAM_000089   PRD_000216   7     PubChem      acetyl-L-leucyl-L-leucylargininal
FAM_000089   PRD_000216   8     PubChem      "L-leucinamide, N-acetyl-L-leucyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)-"
FAM_000089   PRD_000216   9     PubChem      leupeptin
FAM_000089   PRD_000216   10    PubChem      N-acetyl-L-leucyl-L-leucyl-L-argininal
FAM_000089   PRD_000216   11    PubChem      N-acetyl-L-leucyl-N-[(1R)-4-{[amino(imino)methyl]amino}-1-formylbutyl]-L-leucinamide
FAM_000089   PRD_000216   12    PubChem      NK-381
FAM_000089   PRD_000216   13    PubChem      "valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl-"
FAM_000089   PRD_000216   14    SciFinder    Acetyl-L-leucyl-L-leucylargininal
FAM_000089   PRD_000216   15    SciFinder    "Leupeptin Ac-LL"
FAM_000089   PRD_000216   16    SciFinder    "Valeramide, 2-(2-acetamido-4-methylvaleramido)-N-(1-formyl-4-guanidinobutyl)-4-methyl- (8CI)"
FAM_000089   PRD_000216   17    SciFinder    "Leupeptin hemisulfate"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000089   PRD_000216   1     Wikipedia            Function                  "Leupeptin is a competitive inhibitor of serine and cysteine proteases reversibly. Leupeptin inhibits serine proteinases, trypsin, plasmin, porcine kallikrein, and cysteine proteinases, papain, cathepsin B, endoproteinase Lys-C. It does not inhibit chymotrypsin or thrombin."
FAM_000089   PRD_000216   2     PubChem              Function                  "A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors."
FAM_000089   PRD_000216   3     Merck                Function                  "Class of modified protease inhibitors poroduced by various species of Actinomycetes."
FAM_000089   PRD_000216   4     MEROPS               Function
;The discovery of leupeptin in the late 1960s drew attention to the potential of aldehydes as peptidase inhibitors.Many aldehydes are now known as inhibitors of serine, cysteine or threonine peptidases. They form hemiacetal orthiohemiacetal conjugates with the essential hydroxyl or thiol group of the enzyme that are transition state analogues.The compounds exist predominantly in their hydrated forms in aqueous solution, but only the aldehyde is an effectiveinhibitor. Aldehydes can also act as inhibitors of metallopeptidases. Leupeptin is a slow, tight-binding, transitionstate analogue inhibitor of cathepsin B. Leupeptin inhibits a wide range of serine (families S1, S8), cysteine(families C1, C11) and threonine (family T1) peptidases. Apart from numerous peptidases in families S1 and C1,leupeptin is a potent inhibitor of clostripain C11.001 and PACE4 S08.075 and the trypsin-like activity of theproteasome T01.011
;
FAM_000089   PRD_000216   5     PMID:19128015        Function                  "Inhibitor of Cysteine Protease Falcipain-3, EC:3.4.22.-"
FAM_000089   PRD_000216   6     PMID:17881000        Function                  "Inhibitor of Kallikrein-5, EC:3.4.21.-"
FAM_000089   PRD_000216   7     DOI:10.2210/pdb2p0r/pdb Function                  "Inhibitor of Calpain-9; EC:3.4.22.52"
FAM_000089   PRD_000216   8     PMID:16793521        Function                  "Inhibitor of Cysteine Proteinase EP-B 2, EC:3.4.22.-"
FAM_000089   PRD_000216   9     PMID:16414069        Function                  "Inhibitor of alpha I Tryptase, EC:3.4.21.59"
FAM_000089   PRD_000216   10    PMID:11893336        Function                  "Inhibitor of Calpain 1, EC:3.4.22.52"
FAM_000089   PRD_000216   11    PMID:8845765         Function                  "Inhibitor of Trypsin, EC:3.4.21.4"
FAM_000089   PRD_000216   12    PMID:8416808         Function                  "inhibitor of papain, EC: 3.4.22.2"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000089   PRD_000216   1     1     Wikipedia              URL                       http://en.wikipedia.org/wiki/Leupeptin
FAM_000089   PRD_000216   2     1     Labome.com             URL                       http://www.labome.com/review/reagent/leupeptin.html
FAM_000089   PRD_000216   3     1     CAS                    External_Reference_ID     103476-89-7
FAM_000089   PRD_000216   4     1     berkeley.edu           URL                       http://potency.berkeley.edu/chempages/LEUPEPTIN.html
FAM_000089   PRD_000216   5     1     PubChem                External_Reference_ID     3910
FAM_000089   PRD_000216   6     1     ChEBI                  External_Reference_ID     109342
FAM_000089   PRD_000216   7     1     ChemBank               External_Reference_ID     907367
FAM_000089   PRD_000216   8     1     ChemSpider             External_Reference_ID     3773
FAM_000089   PRD_000216   9     1     Calbiochem             External_Reference_ID     108975
FAM_000089   PRD_000216   10    1     ChemDB                 External_Reference_ID     3967241
FAM_000089   PRD_000216   11    1     KEGG                   KEGG_Compound_ID          C01591
FAM_000089   PRD_000216   12    1     Merck                  External_Reference_ID     14:5456
FAM_000089   PRD_000216   13    1     MEROPS                 External_Reference_ID     J00027
FAM_000089   PRD_000216   14    2     PubChem                External_Reference_ID     439527
FAM_000089   PRD_000216   15    1     ChemIDplus             External_Reference_ID     024365477
FAM_000089   PRD_000216   16    2     CAS                    External_Reference_ID     24365-47-7
FAM_000089   PRD_000216   17    1     MESH                   External_Reference_ID     C032854
FAM_000089   PRD_000216   18    3     PubChem                External_Reference_ID     3033938
FAM_000089   PRD_000216   19    1     BindingDB              External_Reference_ID     12041
FAM_000089   PRD_000216   20    2     ChEBI                  External_Reference_ID     468978
FAM_000089   PRD_000216   21    2     ChemSpider             External_Reference_ID     2298508
FAM_000089   PRD_000216   22    1     LeadScope              External_Reference_ID     LS-87930
FAM_000089   PRD_000216   23    1     Merck                  Image                     http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=108975
FAM_000089   PRD_000216   24    1     Nature                 Image                     http://www.nature.com/nchembio/journal/v4/n9/images/nchembio.104-comp15.gif
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000089	2012-02-08	RCSB	"Create family"	
FAM_000089	2013-10-16	RCSB	"Initial release"	
#
