data_FAM_000079
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000079
_pdbx_reference_molecule_family.name            EFRAPEPTIN
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000079   PRD_000186  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000079   PRD_000186   1     PDB          EFRAPEPTIN
FAM_000079   PRD_000186   2     SciFinder    "Efrapeptin C (9CI)"
FAM_000079   PRD_000186   3     SciFinder    "Efrapeptin D"
FAM_000079   PRD_000186   4     SciFinder
;14-[N-[1-[(2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidinium-1-yl)methyl]-3-methylbutyl]-2-methylalaninamide]-, (S)-
;
FAM_000079   PRD_000186   5     SciFinder    "Pyrrolo[1,2-a]pyrimidine, efrapeptin D deriv."
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000079   PRD_000186   1     PMID:8790345         Function                  "inhibits both ATP synthesis and hydrolysis by binding to the F1 catalytic domain of F1F0-ATP synthase"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000079   PRD_000186   1     1     CAS                    External_Reference_ID     138145-54-7
FAM_000079   PRD_000186   2     1     MESH                   MESH_Unique_ID            C012953
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  2008    61   365   371  ?                              18667784  " Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp."                                                                                                                                                         "J Antibiot (Tokyo)."  
 2  1991    58   180   188  10.1016/0022-2011(91)90062-U          ?  " Antifungal and insecticidal properties of the efrapeptins: metabolites of the fungus Tolypocladium niveum."                                                                                                                                                  "Journal of Invertebrate Pathology"  
 3  2008    61   365   371  10.1038/ja.2008.51                    ?  " Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp."                                                                                                                                                         "The Journal of Antibiotics"  
 4  1992    18  1727  1741  10.1007/BF02751098                    ?  " Efrapeptin production byTolypocladium fungi (Deuteromycotina Hyphomycetes): Intra- and interspecific variation"                                                                                                                                              "Journal of Chemical Ecology"  
 5  2007     4  1170  1182  ?                              17589859  "Synthesis, and structural and biological studies of efrapeptin C analogues."                                                                                                                                                                                  "Chem Biodivers."  
 6  2000   104   537   544  10.1017/S0953756299001859             ?  " Production of efrapeptins by Tolypocladium species and evaluation of their insecticidal and antimicrobial properties"                                                                                                                                        "Mycological Research"  
 7  2002    41  4267  4269  ?                              12434358  "The first total synthesis of efrapeptin C."                                                                                                                                                                                                                   "Angewandte Chemie (International ed. in English)"  
 8  2001  1510   367   377  10.1016/S0005-2736(00)00370-9         ?  " Effects of efrapeptin and destruxin, metabolites of entomogenous fungi, on the hydrolytic activity of a vacuolar type ATPase identified on the brush border membrane vesicles of Galleria mellonella midgut and on plant membrane bound hydrolytic enzymes"  "Biochimica et Biophysica Acta (BBA) - Biomembranes"  
 9  1978   253  7609  7611  ?                                151685  " Efrapeptin prevents modification by phenylglyoxal of an essential arginyl residue in mitochondrial adenosine triphosphatase."                                                                                                                                "The Journal of Biological Chemistry"  
11  1992    57  2306  2313  10.1021/jo00034a022                   ?  " Structure of efrapeptins from the fungus Tolypocladium niveum: peptide inhibitors of mitochondrial ATPase"                                                                                                                                                   "J. Org. Chem."  
13  1991   113   707   709  10.1021/ja00002a068                   ?  " Structures of the efrapeptins: potent inhibitors of mitochondrial ATPase from the fungus Tolypocladium niveum"                                                                                                                                               "J. Am. Chem. Soc."  
14  1996     3   283   288  ?                                     ?  " Crystal-State Structure of the C-terminal pentapeptide of the antibiotic Efrapeptin C"                                                                                                                                                                       "Protein & Peptide Letters"  
15  2006    59   267   280  10.1038/ja.2006.38                    ?  " Structure Determination of Neoefrapeptins A to N: Peptides with Insecticidal Activity Produced by the Fungus Geotrichum candidum"                                                                                                                            "The Journal of Antibiotics"  
16  2002    41  4267  4269  ?                              12434358  "The first total synthesis of efrapeptin C."                                                                                                                                                                                                                   "Angew Chem Int Ed Engl."  
17  1991    58   180   188  ?                                     ?  " Antifungal and insecticidal properties of the efrapeptins: metabolites of the fungus Tolypocladium niveum"                                                                                                                                                   "Journal of invertebrate pathology"  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1   1  "Hayakawa, Y."  
 1   2  "Hattori, Y."  
 1   3  "Kawasaki, T."  
 1   4  "Kanoh, K."  
 1   5  "Adachi, K."  
 1   6  "Shizuri, Y."  
 1   7  "Shin-Ya, K."  
 2   8  "Krasnoff, S.B."  
 2   9  "Gupta, S."  
 2  10  "St Leger, R.J."  
 2  11  "Renwick, J.A.A."  
 2  12  "Roberts, D.W."  
 3  13  "Hayakawa, Y."  
 3  14  "Hattori, Y."  
 3  15  "Kawasaki, T."  
 3  16  "Kanoh, K."  
 3  17  "Adachi, K."  
 3  18  "Shizuri, Y."  
 3  19  "Shin-ya, K."  
 4  20  "Krasnoff, S.B."  
 4  21  "Gupta, S."  
 5  22  "Jost, M."  
 5  23  "Weigelt, S."  
 5  24  "Huber, T."  
 5  25  "Majer, Z."  
 5  26  "Greie, J.-C."  
 5  27  "Altendorf, K."  
 5  28  "Sewald, N."  
 6  29  "Bandani, A.R."  
 6  30  "Khambay, B.P.S."  
 6  31  "Faull, J.L."  
 6  32  "Newton, R."  
 6  33  "Deadman, M."  
 6  34  "Butt, T.M."  
 7  35  "Jost, M."  
 7  36  "Greie, J.-C."  
 7  37  "Stemmer, N."  
 7  38  "Wilking, S.D."  
 7  39  "Altendorf, K."  
 7  40  "Sewald, N."  
 8  41  "Bandani, A.R."  
 8  42  "Amiri, B."  
 8  43  "Butt, T.M."  
 8  44  "Gordon-Weeks, R."  
 9  45  "Kohlbrenner, W.E."  
 9  46  "Cross, R.L."  
11  47  "Gupta, S."  
11  48  "Krasnoff, S.B."  
11  49  "Roberts, D.W."  
11  50  "Renwick, J.A.A."  
11  51  "Brinen, L.S."  
11  52  "Clardy, J."  
13  53  "Gupta, S."  
13  54  "Krasnoff, S.B."  
13  55  "Roberts, D.W."  
13  56  "Renwick, J.A.A."  
13  57  "Brinen, L.S."  
13  58  "Clardy, J."  
14  59  "Benedetti, E."  
14  60  "Iacovino, R."  
14  61  "Saviano, M."  
14  62  "Kamphuis, J."  
14  63  "Crisma, M."  
14  64  "Formaggio, F."  
14  65  "Moretto, V."  
14  66  "Toniolo, C."  
15  67  "Fredenhagen, A."  
15  68  "Molleyres, L.-P."  
15  69  "Bohlendorf, B."  
15  70  "Laue, G."  
16  71  "Jost, M."  
16  72  "Greie, J.C."  
16  73  "Stemmer, N."  
16  74  "Wilking, S.D."  
16  75  "Altendorf, K."  
16  76  "Sewald, N."  
17  77  "Krasnoff, S.B."  
17  78  "Gupta, S."  
17  79  "St Leger, R.J."  
17  80  "Renwick, J.A.A."  
17  81  "Roberts, D.W."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000079	2012-02-08	RCSB	"Create family"	
FAM_000079	2013-10-16	RCSB	"Initial release"	
#
