data_FAM_000288
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000288
_pdbx_reference_molecule_family.name            "statine and statine derivative containing inhibitors"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000288   PRD_000392  
FAM_000288   PRD_000416  
FAM_000288   PRD_000432  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000288   PRD_000416   1     PDB          CP-81,282
FAM_000288   PRD_000416   2     Scifinder
;L-Norleucinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-[(1S)-1-(cyclohexylmethyl)-3,3-difluoro-4-(methylamino)-2,4-dioxobutyl]-(9CI)
;
FAM_000288   PRD_000416   3     Scifinder
;L-Norleucinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-[1-(cyclohexylmethyl)-3,3-difluoro-4-(methylamino)-2,4-dioxobutyl]-, (S)-
;
FAM_000288   PRD_000416   4     Scifinder    "CP 81282"
FAM_000288   PRD_000432   5     Scifinder
;L-Cysteinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-[(1S,2R)-1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-
;
FAM_000288   PRD_000432   6     Scifinder
;L-Cysteinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-[1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-, [R-(R*,S*)]-
;
FAM_000288   PRD_000432   7     Scifinder    "CP 80794"
FAM_000288   PRD_000432   8     Scifinder    Terlakiren
FAM_000288   PRD_000432   9     Beilstein
;(2R,3S)-4-Cyclohexyl-2-hydroxy-3-((R)-3-methylsulfanyl-2-{(S)-2-[(morpholine-4-carbonyl)-amino]-3-phenyl-propionylamino}-propionylamino)-butyric acid isopropyl ester
;
FAM_000288   PRD_000432   10    KEGG         Terlakiren
FAM_000288   PRD_000432   11    PubChem      Terlakiren
FAM_000288   PRD_000432   12    PubChem      "MOR-PHE-CYM-NOR Terlakiren"
FAM_000288   PRD_000432   13    PubChem      Terlakiren
FAM_000288   PRD_000432   14    PubChem      CID64922
FAM_000288   PRD_000432   15    PubChem      "CP 80794"
FAM_000288   PRD_000432   16    PubChem      D03743
FAM_000288   PRD_000432   17    PubChem      "Isopropyl (alphaR,betaS)-alpha-hydroxy-beta-((R)-3-(methylthio)-2-((S)-alpha-4-morpholinecarboxamidohydrocinnamamido) propionamido)cyclohexanebutyrate"
FAM_000288   PRD_000432   18    PubChem      "L-Cysteinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-(1-(cyclohexylmethyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl)-S-methyl-, (R-(R*,S*))-"
FAM_000288   PRD_000432   19    ChemSpider   "[R-(R*,S* )]-N-(4-Morpholinylcarbonyl)-L-phenylalanyl-N-[1-(cyclohexylmet hyl)-2-hydroxy-3-(1-methylethoxy)-3-oxopropyl]-S-methyl-L-cyste inamide"
FAM_000288   PRD_000432   20    ChemSpider   CP-80,794
FAM_000288   PRD_000432   21    ChemSpider   "Isopropyl (aR,bS)-a-hydroxy-b-[(R)-3-(methylthio)-2-[(S)-a-4-morpholinec arboxamidohydrocinnamamido] propionamido]cyclohexanebutyratesteinamide"
FAM_000288   PRD_000432   22    ChemSpider   "Isopropyl (alphaR,betaS)-alpha-hydroxy-beta-((R)-3-(methylthio)-2-((S)-a lpha-4-morpholinecarboxamidohydrocinnamamido)propionamido)cyclo hexanebutyrate"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000288   PRD_000416   1     PMID:1304340         Function                  "Inhibitor of ENDOTHIAPEPSIN, EC: 3.4.23.22"
FAM_000288   PRD_000432   2     PMID:12083527        Function                  "Inhibitor of ENDOTHIAPEPSIN, EC: 3.4.23.22"
FAM_000288   PRD_000432   3     KEGG                 Function                  "renin inhibitor"
FAM_000288   PRD_000392   4     PMID:8254610         Function                  "Inhibitor of ENDOTHIAPEPSIN, EC: 3.4.23.22"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000288   PRD_000416   1     1     PubChem                External_reference_ID     445400
FAM_000288   PRD_000416   2     1     ChemSpider             External_reference_ID     393051
FAM_000288   PRD_000432   3     1     MeSH                   MeSH_Unique_ID            C076964
FAM_000288   PRD_000432   4     1     Beilstein              External_reference_ID     4776080
FAM_000288   PRD_000432   5     1     KEGG                   KEGG_Drug_ID              D03743
FAM_000288   PRD_000432   6     1     PubChem                External_reference_ID     64922
FAM_000288   PRD_000432   7     1     ChemSpider             External_reference_ID     58451
FAM_000288   PRD_000432   8     1     CAS                    External_reference_ID     119625-78-4
FAM_000288   PRD_000432   9     1     ChEBI                  External_reference_ID     196469
FAM_000288   PRD_000432   10    1     ChemIDplus             External_reference_ID     119625784
FAM_000288   PRD_000392   11    1     PubChem                External_reference_ID     15018015
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000288	2012-02-08	RCSB	"Create family"	
FAM_000288	2013-10-16	RCSB	"Initial release"	
#
