data_FAM_000088
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000088
_pdbx_reference_molecule_family.name            MICROCYSTIN
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000088   PRD_000212  
FAM_000088   PRD_000213  
FAM_000088   PRD_000214  
FAM_000088   PRD_000215  
FAM_000088   PRD_001031  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000088   PRD_000212   1     PDB          "Microcystin LR"
FAM_000088   PRD_000212   2     Sigma_Aldrich "5-L-Arginine-microcystin LA"
FAM_000088   PRD_000212   3     PubChem      "Fast-death factor"
FAM_000088   PRD_000212   4     ChemSpider   "(5R,8S,11R,12S,15S,18S,19S,22R)-15-(3-carbamimidamidopropyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,5,12,19-tetramethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid"
FAM_000088   PRD_000212   5     ChemSpider   "(5R,8S,11R,12S,15S,18S,19S,22R)-15-{3-[(diaminomethylidene)amino]propyl}-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dien-1-yl]-1,5,12,19-tetramethyl-2-methylidene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid"
FAM_000088   PRD_000212   6     ChemSpider   "1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid, 15-[3-[(aminoiminomethyl)amino]propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-, (5R,8S,11R,12S,15S,18S,19S,22R)-"
FAM_000088   PRD_000212   7     ChemSpider   "1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid, 15-[3-[(diaminomethylene)amino]propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-8-(2-methylpropyl)-3,6,9,13,16,20,25-heptaoxo-, (5R,8S,11R,12S,15S,18S,19S,22R)-"
FAM_000088   PRD_000212   8     ChemSpider   "1,7-anhydro[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanine]"
FAM_000088   PRD_000212   9     ChemSpider   "1,7-anhydro[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylalanine] Microcystin-LR"
FAM_000088   PRD_000212   10    ChemSpider   "15-(3-Guanidino-propyl)-8-isobutyl-18-(6-methoxy-3,5-dimethyl-7-phenyl-hepta-1,3-dienyl)-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21heptaaza-cyclopentacosane-11,22-dicarboxylic acid"
FAM_000088   PRD_000212   11    ChemSpider   ACB-ARG-ADD-CAB-MAA-DAL-LEU
FAM_000088   PRD_000212   12    ChemSpider   "cyanoginosin LR"
FAM_000088   PRD_000212   13    ChemSpider   "cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl]"
FAM_000088   PRD_000212   14    ChemSpider   "cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-g lutamyl]toxin-LR"
FAM_000088   PRD_000212   15    ChemSpider   "cyclo[D-alanyl-L-leucyl-(3S)-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl-D-gamma-glutamyl-2,3-didehydro-N-methylal anyl]"
FAM_000088   PRD_000212   16    ChemSpider   microcystin-LR
FAM_000088   PRD_000212   17    ChemSpider   "Microcystis aeruginosa toxin"
FAM_000088   PRD_000212   18    ChemSpider   toxin-LR
FAM_000088   PRD_000212   19    SciFinder    MCLR
FAM_000088   PRD_000212   20    SciFinder    MCYST-LR
FAM_000088   PRD_000212   21    SciFinder    "Toxin I (Microcystis aeruginosa)"
FAM_000088   PRD_000212   22    SciFinder    "Toxin T 17 (Microcystis aeruginosa)"
FAM_000088   PRD_000213   23    PDB          MOQ
FAM_000088   PRD_000213   24    PDB          "(2S,5R,6S,9S,12S,13S,16R)-2-ethyl-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-heptyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-9-propan-2-yl-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid"
FAM_000088   PRD_000213   25    DrugBank     Motuporin
FAM_000088   PRD_000213   26    DrugBank     nodularin-V
FAM_000088   PRD_000213   27    DrugBank     "(2S,5R,6S,9S,12S,13S,16R)-2-ethyl-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenylheptyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-9-propan-2-yl-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid"
FAM_000088   PRD_000213   28    PubChem      MOTUPORIN
FAM_000088   PRD_000213   29    PubChem      "(2S,5R,6S,9S,12S,13S,16R)-2-ethyl-12-[(5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-heptyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-9-propan-2-yl-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid"
FAM_000088   PRD_000213   30    PubChem      "(2S,5R,6S,9S,12S,13S,16R)-2-ETHYL-9-ISOPROPYL-12-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,6,13-TRIMETHYL-3,7,10,14,19-PENTAOXO-1,4,8,11,15-PENTAAZACYCLONONADECANE-5,16-DICARBOXYLIC ACID"
FAM_000088   PRD_000213   31    SciFinder    "1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide deriv."
FAM_000088   PRD_000213   32    SciFinder    (-)-Motuporin
FAM_000088   PRD_000213   33    SciFinder    Motuporin
FAM_000088   PRD_000213   34    SciFinder    "Nodularin V"
FAM_000088   PRD_000212   35    PubChem      MCYST-LR
FAM_000088   PRD_000214   36    PubChem      Nodularin
FAM_000088   PRD_000215   37    PubChem      DIHYDROMICROCYSTIN-LA
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000088   PRD_000213   1     DOI:10.1021/jo982145i Function                  "inhibitor of protein phosphatase-1"
FAM_000088   PRD_000213   2     PMID:2174036         Function                  "inhibitor of type 1 and type 2A protein phosphatases"
FAM_000088   PRD_000213   3     PMID:2174896         Function                  "potent tumor promoter"
FAM_000088   PRD_000213   4     PMID:2176489         Function                  "induce hepatocyte deformation"
FAM_000088   PRD_000213   5     DOI:10.1016/S0040-4039(00)91674-5 Function                  cytotoxin
FAM_000088   PRD_000213   6     PMID:9030574         Function                  "powerful liver tumor promoter"
FAM_000088   PRD_000212   7     PMID:7651533         Function                  "inhibitor of PROTEIN SERINE/THREONINE PHOSPHATASE-1, EC: 3.1.3.16"
FAM_000088   PRD_000214   8     PMID:18992256        Function                  "inhibitor of Serine/threonine-protein phosphatase PP1, EC: 3.1.3.16"
FAM_000088   PRD_000215   9     PMID:16343532        Function                  "inhibitor of Serine/threonine protein phosphatase PP1, EC: 3.1.3.16"
FAM_000088   PRD_001031   10    PMID:23752926        Function                  "inhibitor of Serine/threonine-protein phosphatase 2A"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000088   PRD_000212   1     1     CAS                    External_Reference_ID     101043-37-2
FAM_000088   PRD_000212   2     1     Wikipedia              URL                       http://en.wikipedia.org/wiki/Microcystin
FAM_000088   PRD_000212   3     1     Wikipedia              Image                     http://upload.wikimedia.org/wikipedia/commons/c/c0/Microcystin-LR.png
FAM_000088   PRD_000212   4     1     cyanocbacteria-platform URL                       http://www.cyanobacteria-platform.com/cyanotoxins.html
FAM_000088   PRD_000212   5     1     cyanocbacteria-platform Image                     http://www.cyanobacteria-platform.com/Material/Microcystin.gif
FAM_000088   PRD_000212   6     1     MERHAB-LGL             Image                     http://www.esf.edu/merhab/images/toxins/microcystin.gif
FAM_000088   PRD_000212   7     1     Purdue                 URL                       http://www-cyanosite.bio.purdue.edu/cyanotox/toxins/microcystins.html
FAM_000088   PRD_000212   8     1     Sigma-aldrich          Image                     http://www.sigmaaldrich.com/structureimages/07/mfcd00131607.gif
FAM_000088   PRD_000212   9     1     PubChem                External_Reference_ID     3770215
FAM_000088   PRD_000212   10    2     PubChem                External_Reference_ID     445434
FAM_000088   PRD_000212   11    1     KEGG                   KEGG_Compound_ID          C05371
FAM_000088   PRD_000212   12    1     KEGG                   Image                     http://www.genome.jp/Fig/compound/C05371.gif
FAM_000088   PRD_000212   13    1     CAS                    External_Reference_ID     101043-37-2
FAM_000088   PRD_000212   14    1     ChemSpider             External_Reference_ID     393078
FAM_000088   PRD_000212   15    1     ChEBI                  External_Reference_ID     103858
FAM_000088   PRD_000212   16    2     ChEBI                  External_Reference_ID     6925
FAM_000088   PRD_000213   17    1     DrugBank               External_Reference_ID     DB04738
FAM_000088   PRD_000213   18    1     CAS                    External_Reference_ID     141672-08-4
FAM_000088   PRD_000213   19    1     PubChem                External_Reference_ID     5494429
FAM_000088   PRD_000213   20    2     PubChem                External_Reference_ID     8149093
FAM_000088   PRD_000213   21    1     ChemSpider             External_Reference_ID     4591878
FAM_000088   PRD_000213   22    1     http://ethesis.helsinki.fi Image                     http://ethesis.helsinki.fi/julkaisut/maa/skemi/vk/lehtimaki/fig1.gif
FAM_000088   PRD_000214   23    1     PubChem                External_Reference_ID     14217092
FAM_000088   PRD_000214   24    1     CAS                    External_Reference_ID     118399-22-7
FAM_000088   PRD_000214   25    1     CHEMBL                 External_Reference_ID     108308
FAM_000088   PRD_000214   26    1     CHEBI                  External_Reference_ID     279920
FAM_000088   PRD_000215   27    1     PubChem                External_Reference_ID     9543479
FAM_000088   PRD_000215   28    1     ChemSpider             External_Reference_ID     7822433
FAM_000088   PRD_001031   29    1     PubChem                External_Reference_ID     71306458
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  2005   25     73     95  ?                                   16294828  "Bioactive Compounds from Cyanobacteria and Microalgae: An Overview"                                                                                                                 "Critical Reviews in Biotechnology"  
 2  2000  145     65     87  10.1385/1592590527                         ?  "Isolation and Detection of Microcystins and Nodularins, Cyanobacterial Peptide Hepatotoxins"                                                                                        "Methods in Molecular Biology, Bacterial Toxins: Methods and Protocols, Editer Otto Holst"  
 3  1984    ?   2311   2318  10.1039/P19840002311                       ?  "The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa"                                                                       "J. Chem. Soc. Perkin Trans. 1"  
 4  1988  110   8557   8558  10.1021/ja00233a049                        ?  "Nodularin, microcystin, and the configuration of Adda."                                                                                                                             "J. Am. Chem. Soc."  
 5  1982   20    945    954  10.1016/0041-0101(82)90097-6         6819659  "Isolation and characterization of four toxins from the blue-green alga, Microcystis aeruginosa."                                                                                    Toxicon  
 6  1992   72    445    459  ?                                    1644701  "Cyanobacteria secondary metabolites - The cyanotoxins."                                                                                                                             "J. Appl. Bacteriol."  
 7  1996   32    591    597  10.1111/j.1529-8817.1996.tb02154.x         ?  "Evidence that microcystin is a thio-template product"                                                                                                                               "Journal of Phycology"  
 8  1985    ?   2747   2748  10.1039/P19850002747                       ?  "Structural studies on cyanoginosins-LR, -YR, -YA, and -YM, peptide toxins from Microcystis aeruginosa"                                                                              "J. Chem. Soc. Perkin Trans. 1"  
 9  1987   28   4695   4698  10.1016/S0040-4039(00)96600-0              ?  "Cyanoviridin RR, a toxin from the cyanobacterium (blue-green alga) Microcystis viridis."                                                                                            "Tetrahedron Lett."  
10  1986   24    865    873  10.1016/0041-0101(86)90087-5         3101230  " Toxic peptides from freshwater cyanobacteria (blue-green algae). I. Isolation, purification and characterization of peptides from Microcystis aeruginosa and Anabaena flos-aquae"  Toxicon  
11  1989   27   1021   1034  10.1016/0041-0101(89)90153-0         2508270  "Structure and toxicity of a peptide hepatotoxin from the cyanobacterium Oscillatoria agardhii."                                                                                     Toxicon  
12  1990   55   6135   6139  10.1021/jo00312a019                        ?  " Structures of three new cyclic heptapeptide hepatotoxins produced by the cyanobacterium (blue-green alga) Nostoc sp. strain 152."                                                  "J. Org. Chem."  
13  1999   64   2711   2728  10.1021/jo982145i                          ?  "Total Synthesis of Motuporin and 5-[l-Ala]-Motuporin"                                                                                                                               "J. Org. Chem."  
14  2002  124  11368  11378  10.1021/ja0206700                          ?  "Enantioselective Synthesis of the Protein Phosphatase Inhibitor Motuporin"                                                                                                          "J. Am. Chem. Soc."  
15  1995    2    114    116  10.1038/nsb0295-114                        ?  "Comparison of the solution structures of microcystin-LR and motuporin"                                                                                                              "Nature Structural Biology"  
16  1994  270     78     86  ?                                    8284661  "The toxins of cyanobacteria"                                                                                                                                                        "Sci Am."  
17  1990  265  19401  19404  ?                                    2174036  " Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases."                                                                                "J Biol Chem."  
18  1990  116    609    614  ?                                    2174896  " Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity"                                                                                   "J Cancer Res Clin Oncol."  
19  1990  264    187    192  10.1016/0014-5793(90)80245-E               ?  " Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants"                                             "FEBS Letters"  
20  1993    3    934    943  10.1016/0959-440X(93)90159-I               ?  " Inhibitors of protein phosphatase-1 and -2A; two of the major serine/threonine protein phosphatases involved in cellular regulation"                                               "Current Opinion in Structural Biology"  
21  1990  173   1347   1353  ?                                    2176489  " Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases"                                                                               "Biochem Biophys Res Commun."  
22  1992   33   1561   1564  10.1016/S0040-4039(00)91674-5              ?  " Motuporin, A Potent Protein Phosphatase Inhibitor Isolated from the Papua New Guinea Sponge Theonella swinhoei Gray"                                                               "Tetrahedron Letters"  
23  1996   74    569    578  ?                                    8960363  " Molecular mechanisms underlying he interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases"                                                         "Biochem Cell Biol."  
24  1997  272   5087   5097  10.1074/jbc.272.8.5087               9030574  " A molecular basis for different interactions of marine toxins with protein phosphatase-1. Molecular models for bound motuporin, microcystins, okadaic acid, and calyculin A"       "J Biol Chem."  
25  2007   70     89     94  ?                                   17253855  "A serendipitous discovery of isomotuporin-containing sponge populations of Theonella swinhoei"                                                                                      "J Nat Prod"  
26  2010    8    122    172  10.3390/md80100122                         ?  " Calyculins and Related Marine Natural Products as Serine- Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C"                      "Marine Drugs"  
27  2009    2     31     50  10.1608/FRJ-2.1.2                          ?  "The genetic basis of toxin production in Cyanobacteria"                                                                                                                             "Freshwater Reviews"  
28  2001   35   4849   4856  ?                                   11775161  "Congener-independent immunoassay for microcystins and nodularins"                                                                                                                   "Environ Sci Technol."  
29  2004    2    123    146  10.3390/md203123                           ?  "Biomedical Compounds from Marine organisms"                                                                                                                                         "Marine Drugs"  
30  1999  181   4089   4097  ?                                   10383979  "Nonribosomal peptide synthesis and toxigenicity of cyanobacteria"                                                                                                                   "J Bacteriol."  
31  1988   26    971    973  ?                                    3149803  "Naming cyclic heptapeptide toxins of cyanobacteria (blue-green algae)"                                                                                                              Toxicon  
32  1992   72    445    459  ?                                    1644701  "Cyanobacteria secondary metabolites--the cyanotoxins."                                                                                                                              "J Appl Bacteriol."  
33  2000  146   2865   2875  ?                                   11065365  " Allele-specific PCR shows that genetic exchange occurs among genetically diverse Nodularia (cyanobacteria) filaments in the Baltic Sea."                                           Microbiology  
34  2004  101    568    573  ?                                   14701903  "Phylogenetic evidence for the early evolution of microcystin synthesis"                                                                                                             "Proc Natl Acad Sci U S A."  
35  2008   38    847    856  10.1080/10408440802291513                  ?  " The Molecular Genetics and Regulation of Cyanobacterial Peptide Hepatotoxin Biosynthesis"                                                                                          "Critical Reviews in Toxicology"  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1    1  "Singh, S."  
 1    2  "Kate, B.N."  
 1    3  "Banerjee, U.C."  
 2    4  "Meriluoto, J."  
 2    5  "Lawton, L."  
 2    6  "Harada, K."  
 3    7  "Botes, D.P."  
 3    8  "Tuinman, A.A."  
 3    9  "Wessels, P.L."  
 3   10  "Viljoen, C.C."  
 3   11  "Kruger, H."  
 3   12  "Williams, D.H."  
 3   13  "Santikarn, S."  
 3   14  "Smith, R.J."  
 3   15  "Hammond, S.J."  
 4   16  "Rinehart, K.L."  
 4   17  "Harada, K.I."  
 4   18  "Namikoshi, M."  
 4   19  "Chen, C."  
 4   20  "Harvis, C.A."  
 4   21  "Munro, M.H.G."  
 4   22  "Blunt, J.W."  
 4   23  "Mulligan, P.E."  
 4   24  "Beasley, V.R."  
 4   25  "Dahlem, A.M."  
 4   26  "Carmichael, W.W."  
 5   27  "Botes, D.P."  
 5   28  "Kruger, H."  
 5   29  "Viljoen, C.C."  
 6   30  "Carmichael, W.W."  
 7   31  "Arment, A.R."  
 7   32  "Carmichael, W.W."  
 8   33  "Botes, D.P."  
 8   34  "Wessels, P.L."  
 8   35  "Kruger, H."  
 8   36  "Runnegar, M.T.C."  
 8   37  "Santikarn, S."  
 8   38  "Smith, R.J."  
 8   39  "Barna, J.C.J."  
 8   40  "Williams, D.H."  
 9   41  "Kusumi, T."  
 9   42  "Ooi, T."  
 9   43  "Watanabe, M.M."  
 9   44  "Takahashi, H."  
 9   45  "Kakisawa, H."  
10   46  "Krishnamurthy, T."  
10   47  "Carmichael, W.W."  
10   48  "Sarver, E.W."  
11   49  "Meriluoto, J.A.O."  
11   50  "Sandstroumlm, A."  
11   51  "Eriksson, J.E."  
11   52  "Remaud, G."  
11   53  "Craig, A.G."  
11   54  "Chattopadhyaya, J."  
12   55  "Namikoshi, M."  
12   56  "Rinehart, K.L."  
12   57  "Sakai, R."  
12   58  "Sivonen, K."  
12   59  "Carmichael, W.W."  
13   60  "Samy, R."  
13   61  "Kim, H.Y."  
13   62  "Brady, M."  
13   63  "Toogood, P.L."  
14   64  "Hu, T."  
14   65  "Panek, J.S."  
15   66  "Bagu, J.R."  
15   67  "Sonnichsen, F.D."  
15   68  "Williams, D."  
15   69  "Andersen, R.J."  
15   70  "Sykes, B.D."  
15   71  "Holmes, C.F.B."  
16   72  "Carmichael, W.W."  
17   73  "Honkanen, R.E."  
17   74  "Zwiller, J."  
17   75  "Moore, R.E."  
17   76  "Daily, S.L."  
17   77  "Khatra, B.S."  
17   78  "Dukelow, M."  
17   79  "Boynton, A.L."  
18   80  "Yoshizawa, S."  
18   81  "Matsushima, R."  
18   82  "Watanabe, M.F."  
18   83  "Harada, K."  
18   84  "Ichihara, A."  
18   85  "Carmichael, W.W."  
18   86  "Fujiki, H."  
19   87  "MacKintosh, C."  
19   88  "Beattie, K.A."  
19   89  "Klumpp, S."  
19   90  "Cohen, P."  
19   91  "Codd, G.A."  
20   92  "Holmes, C.F.B."  
20   93  "Boland, M.P."  
21   94  "Eriksson, J.E."  
21   95  "Toivola, D."  
21   96  "Meriluoto, J.A."  
21   97  "Karaki, H."  
21   98  "Han, Y.G."  
21   99  "Hartshorne, D."  
22  100  "Dilip de Silva, E."  
22  101  "Williams, D.E."  
22  102  "Andersen, R.J."  
22  103  "Klix, H."  
22  104  "Holmes, C.F.B."  
22  105  "Allen, T.M."  
23  106  "Craig, M."  
23  107  "Luu, H.A."  
23  108  "McCready, T.L."  
23  109  "Williams, D."  
23  110  "Andersen, R.J."  
23  111  "Holmes, C.F."  
24  112  "Bagu, J.R."  
24  113  "Sykes, B.D."  
24  114  "Craig, M.M."  
24  115  "Holmes, C.F."  
25  116  "Wegerski, C.J."  
25  117  "Hammond, J."  
25  118  "Tenney, K."  
25  119  "Matainaho, T."  
25  120  "Crews, P."  
26  121  "Fagerholm, A.E."  
26  122  "Habrant, D."  
26  123  "Koskinen A.M.P."  
27  124  "Kurmayer, R."  
27  125  "Christiansen, G."  
28  126  "Fischer, W.J."  
28  127  "Garthwaite, I."  
28  128  "Miles, C.O."  
28  129  "Ross, K.M."  
28  130  "Aggen, J.B."  
28  131  "Chamberlin, A.R."  
28  132  "Towers, N.R."  
28  133  "Dietrich, D.R."  
29  134  "Jha, R.K."  
29  135  "Zi-rong, X."  
30  136  "Neilan, B.A."  
30  137  "Dittmann, E."  
30  138  "Rouhiainen, L."  
30  139  "Bass, R.A."  
30  140  "Schaub, V."  
30  141  "Sivonen, K."  
30  142  "Borner, T."  
31  143  "Carmichael, W.W."  
31  144  "Beasley, V."  
31  145  "Burner, D.L."  
31  146  "Eloff, J.N."  
31  147  "Falconer, I."  
31  148  "Gorham, P."  
31  149  "Harada, K.-I."  
31  150  "Krishnamurty, T."  
31  151  "Min-Juan, Y."  
31  152  "Moore, R.E."  
31  153  "Rinehart, K."  
31  154  "Runnegar, M."  
31  155  "Skulberg, O.M."  
31  156  "Watanabe, M."  
32  157  "Carmichael, W.W."  
33  158  "Barker, G.L."  
33  159  "Handley, B.A."  
33  160  "Vacharapiyasophon, P."  
33  161  "Stevens, J.R."  
33  162  "Hayes, P.K."  
34  163  "Rantala, A."  
34  164  "Fewer, D.P."  
34  165  "Hisbergues, M."  
34  166  "Rouhiainen, L."  
34  167  "Vaitomaa, J."  
34  168  "Borner, T."  
34  169  "Sivonen, K."  
35  170  "Pearson, L.A."  
35  171  "Moffitt, M.C."  
35  172  "Ginn, H.P."  
35  173  "Neilan, B.A."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000088	2012-02-08	RCSB	"Create family"	
FAM_000088	2013-10-16	RCSB	"Initial release"	
#
