data_FAM_000417
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000417
_pdbx_reference_molecule_family.name            Acyldepsipeptide
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000417   PRD_000503  
FAM_000417   PRD_000504  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000417   PRD_000503   1     PDB          "Acyldepsipeptide 1"
FAM_000417   PRD_000504   2     PDB          "Acyldepsipeptide 2"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000417   PRD_000503   1     Norine               Function                  Antibtioic
FAM_000417   PRD_000503   2     PMID:20305655        Function                  "Activator of ATP-dependent ClpP, EC: 3.4.21.92"
FAM_000417   PRD_000504   3     PMID:20305655        Function                  "Activator of ATP-dependent ClpP, EC: 3.4.21.92"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000417   PRD_000503   1     1     Norine                 External_Reference_ID     NOR01131
FAM_000417   PRD_000503   2     1     Nature                 Image                     http://www.nature.com/nbt/journal/v24/n12/fig_tab/nbt1266_F1.html
FAM_000417   PRD_000504   3     1     Nature                 Image                     http://www.nature.com/nbt/journal/v24/n12/fig_tab/nbt1266_F1.html
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  2006   24  1541  1550  ?                              17160060  "New antibiotics from bacterial natural products"                                                                                          "Nat Biotechnol."  
 2  1994   47   922   931  ?                               7928680  " Solution conformation of enopeptin A, a depsipeptide antibiotic, using 2D NMR and restrained molecular dynamics studies."                "J. Antibiot."  
 3  2006    1   689   693  10.1002/cmdc.200600055         16902918  "Medicinal chemistry optimization of acyldepsipeptides of the enopeptin class antibiotics."                                                ChemMedChem.  
 4  2005   11  1082  1087  10.1038/nm1306                        ?  "Dysregulation of bacterial proteolytic machinery by a new class of antibiotics"                                                           "Nature Medicine"  
 5  2006    9   445   462  ?                              16889228  "Rational approaches to natural-product-based drug design"                                                                                 "Curr Opin Drug Discov Devel."  
 6  1997   53  1577  1582  10.1016/S0040-4020(96)01136-2         ?  "Kailuins A-D, new cyclic acyldepsipeptides from cultures of a marine-derived bacterium"                                                   Tetrahedron  
 7  1999   37   801   813  10.1016/S0041-0101(98)00219-0         ?  " The membranotropic activity of cyclic acyldepsipeptides from bacterium Bacillus pumilus, associated with the marine sponge Ircinia sp."  Toxicon  
 8  2006   15   211   226  10.1517/13543784.15.3.211             ?  " Recent developments in antibacterial drug discovery: microbe-derived natural products from collection to the clinic"                     "Expert Opinion on Investigational Drugs"  
 9  2009  325  1089  1093  10.1126/science.1176667               ?  "Antibiotics for emerging pathogens"                                                                                                       Science  
10  2008    9  1711  1723  ?                              19018725  " New trends in pharmacogenomic strategies against resistance development in microbial infections"                                         Pharmacogenomics  
11  2009    1    37    49  10.1002/emmm.200900002                ?  " The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease"                                        "EMBO Molecular Medicine"  
12  2004   28   441   446  10.1007/s00284-003-4240-0      15170241  " Low-Molecular-Weight, Biologically Active Compounds from Marine Pseudoalteromonas Species"                                               "Current Microbiology"  
13  2009   16    42    65  ?                              19149562  " Recent Progress in the Discovery of Macrocyclic Compounds as Potential Anti-Infective Therapeutics"                                      "Current Medicinal Chemistry"  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1   1  "Clardy, J."  
 1   2  "Fischbach, M.A."  
 1   3  "Walsh, C.T."  
 2   4  "Young, J.J."  
 2   5  "Jung, L.J."  
 2   6  "Liu, W.T."  
 2   7  "Ho, S.N."  
 2   8  "Chang, L.R."  
 2   9  "Tsai, Y.C."  
 2  10  "Bhaskaran, R."  
 2  11  "Yu, C."  
 3  12  "Hinzen, B."  
 3  13  "Raddatz, S."  
 3  14  "Paulsen, H."  
 3  15  "Lampe, T."  
 3  16  "Schumacher, A."  
 3  17  "Hodbich, D."  
 3  18  "Hellwig, V."  
 3  19  "Benet-Buchholz, J."  
 3  20  "Endermann, R."  
 3  21  "Labischinski, H."  
 3  22  "Broesterhelt, H."  
 4  23  "Brovtz-Oesterhelt, H."  
 4  24  "Beyer, D."  
 4  25  "Kroll, H.-P."  
 4  26  "Endermann, R."  
 4  27  "Ladel, C."  
 4  28  "Schroeder, W."  
 4  29  "Hinzen, B."  
 4  30  "Raddatz, S."  
 4  31  "Paulsen, H."  
 4  32  "Henninger, K."  
 4  33  "Bandow, J.E."  
 4  34  "Sahl, H.-G."  
 4  35  "Labischinski, H."  
 5  36  "Haustedt, L.O."  
 5  37  "Mang, C."  
 5  38  "Siems, K."  
 5  39  "Schiewe, H."  
 6  40  "Harrigan, G.G."  
 6  41  "Harrigan, B.L."  
 6  42  "Davidson, B.S."  
 7  43  "Prokof'eva, N.G."  
 7  44  "Kalinovskaya, N.I."  
 7  45  "Luk'yanov, P.A."  
 7  46  "Shentsova, E.B."  
 7  47  "Kuznetsova, T.A."  
 8  48  "Leeds, J.A."  
 8  49  "Schmitt, E.K."  
 8  50  "Krastel, P."  
 9  51  "Fischbach, M.A."  
 9  52  "Walsh, C.T."  
10  53  "Ohlsen, K."  
10  54  "Dandekar, G."  
10  55  "Schwarz, R."  
10  56  "Dandekar, T."  
11  57  "Kirstein, J."  
11  58  "Hoffmann, A."  
11  59  "Lilie, H."  
11  60  "Schmidt, R."  
11  61  "Robsamen-Waigmann, H."  
11  62  "Brovtz-Oesterhelt, H."  
11  63  "Mogk, A."  
11  64  "Turgay, K."  
12  65  "Kalinovskaya, N.I."  
12  66  "Ivanova, E.P."  
12  67  "Alexeeva, Y.V."  
12  68  "Gorshkova, N.M."  
12  69  "Kuznetsova, T.A."  
12  70  "Dmitrenok, A.S."  
12  71  "Nicolau, D.V."  
13  72  "Obrecht, D."  
13  73  "Robinson, J.A."  
13  74  "Bernardini, F."  
13  75  "Bisang, C."  
13  76  "DeMarco, S.J."  
13  77  "Moehle, K."  
13  78  "Gombert, F.O."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000417	2012-02-08	RCSB	"Create family"	
FAM_000417	2013-10-16	RCSB	"Initial release"	
#
