data_FAM_000027
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000027
_pdbx_reference_molecule_family.name            CYCLIC_HEXAPEPTIDES
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000027   PRD_000102  
FAM_000027   PRD_000103  
FAM_000027   PRD_000104  
FAM_000027   PRD_000105  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000027   PRD_000103   1     PubChem      "(3S,6S,9S,12S,15S,18S)-3,6,12-tris(4-aminobutyl)-9-benzyl-15,18-bis(1H-indol-3-ylmethyl)-1,4,7,10,13,16-hexazacyclooctadecane-2,5,8,11,14,17-hexone"
FAM_000027   PRD_000105   2     PubChem      "3-[(2S,5S,8S,11S,14S,17S)-5-benzyl-8,11-bis[3-(diaminomethylideneazaniumyl)propyl]-14,17-bis(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]propyl-(diaminomethylidene)azanium"
FAM_000027   PRD_000105   3     ChemSpider   "cyclo{N~5~-[amino(iminio)methyl]-L-ornithyl-N~5~-[amino(iminio)methyl]-L-ornithyl-L-tryptophyl-L-tryptophyl-N~5~-[amino(iminio)methyl]-L-ornithyl-L-phenylalanyl}"
FAM_000027   PRD_000102   4     PDB          Cyclo-RR(NAL)(NAL)RF
FAM_000027   PRD_000103   5     PDB          Cyclo-KKWWKF
FAM_000027   PRD_000104   6     PDB          Cyclo-RRYYRF
FAM_000027   PRD_000105   7     PDB          Cyclo-RRWWRF
FAM_000027   PRD_000103   8     SciFinder    Cyclo-AMT1
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000027   PRD_000102   1     PMID:16075425        Function                  "Antimicrobial, cationic peptides, thought to act by rupturing the bacterial membrane"
FAM_000027   PRD_000103   2     PMID:16075425        Function                  "Antimicrobial, cationic peptides, thought to act by rupturing the bacterial membrane"
FAM_000027   PRD_000104   3     PMID:16075425        Function                  "Antimicrobial, cationic peptides, thought to act by rupturing the bacterial membrane"
FAM_000027   PRD_000105   4     PMID:16075425        Function                  "Antimicrobial, cationic peptides, thought to act by rupturing the bacterial membrane"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000027   PRD_000103   1     1     PubChem                External_Reference_ID     656996
FAM_000027   PRD_000103   2     2     PubChem                External_Reference_ID     656995
FAM_000027   PRD_000103   3     1     CAS                    External_Reference_ID     735330-15-1
FAM_000027   PRD_000103   4     1     Beilstein              External_Reference_ID     11141432
FAM_000027   PRD_000103   5     1     ChEBI                  External_Reference_ID     509890
FAM_000027   PRD_000105   6     1     ChEBI                  External_Reference_ID     509889
FAM_000027   PRD_000105   7     1     PubChem                External_Reference_ID     448204
FAM_000027   PRD_000105   8     1     ChemSpider             External_Reference_ID     395079
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
1  2005   89  2296  2306  10.1529/biophysj.105.063040  16040748  " Interaction of the Antimicrobial Peptide Cyclo(RRWWRF) with Membranes by Molecular Dynamics Simulations"                                                       "Biophysical Journal"  
2  2005    6  1654  1662  ?                            16075425  " Structure of the antimicrobial, cationic hexapeptide cyclo(RRWWRF) and its analogues in solution and bound to detergent micelles."                             Chembiochem.  
3  2010  618    87   109  10.1007/978-1-60761-594-1_7         ?  " Synthesis and Thermodynamic Characterization of Small Cyclic Antimicrobial Arginine and Tryptophan-Rich Peptides with Selectivity for Gram-Negative Bacteria"  "Methods in Molecular Biology: Antimicrobial Peptides: Methods and Protocols"  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
1   1  "Appelt, C."  
1   2  "Eisenmenger, F."  
1   3  "Kuhne, R."  
1   4  "Schmieder, P."  
1   5  "Soderhall, J.A."  
2   6  "Appelt, C."  
2   7  "Wessolowski, A."  
2   8  "Soderhall, J.A."  
2   9  "Dathe, M."  
2  10  "Schmieder, P."  
3  11  "Bagheri, M."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000027	2012-02-08	RCSB	"Create family"	
FAM_000027	2013-10-16	RCSB	"Initial release"	
#
