data_FAM_001006
#
_pdbx_reference_molecule_family.family_prd_id   FAM_001006
_pdbx_reference_molecule_family.name            "Lyngbystatin related inhibitors"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
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_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_001006   PRD_000776  
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_pdbx_reference_molecule_related_structures.family_prd_id  FAM_001006
_pdbx_reference_molecule_related_structures.ordinal        1
_pdbx_reference_molecule_related_structures.citation_id    1
_pdbx_reference_molecule_related_structures.db_name        CCDC
_pdbx_reference_molecule_related_structures.db_accession   ?
_pdbx_reference_molecule_related_structures.db_code        CIYQEG
_pdbx_reference_molecule_related_structures.name           " N-[(1S,4S,18S,21S,23S,26S,29Z,32R,35S)-21-Benzyl-29-ethylidene-13,14,23-trihydroxy-35-isopropyl-19,32-dimethyl-3,9,20,28,31,34,37,38,-octaoxo-33-oxa-2,8,10,19,22,27,30,36-octa-azatetracyclo[16.13.6.1-22,26-.0-11,16-]octatriaconta-11,13,15-trien-4-yl]isobutyramide hexahydrate, FR901277 hexahydrate, seqres C6 GLY*-GLY*-PHE*-PHE*-VAL,THR!-, A2 ORN*-THR!"
_pdbx_reference_molecule_related_structures.formula        "C47 H63 N9 O13, 6(H2 O)"
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_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_001006   PRD_000776   1     PMID:23350733        Function                  "inhibitor of Chymotrypsin-like elastase family member 1 , EC: 3.4.21.36"
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_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_001006   PRD_000776   1     1     PubChem                External_reference_ID     70698426
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_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
1  1999   9  2397  2402  10.1016/S0960-894X(99)00408-4  10476876  "Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation"  Bioorg.Med.Chem.Lett.  
2  1994  29   195   204  10.1016/S0065-7743(08)60733-2         ?  "Chapter 20. Human Leukocyte Elastase Inhibitors"                                                                  "Annual Reports in Medicinal Chemistry"  
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_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
1  1  "Nakanishi, I."  
1  2  "Kinoshita, T."  
1  3  "Tada, T."  
1  4  "Fujita, T."  
1  5  "Hatanaka, H."  
1  6  "Sato, A."  
2  7  "Hlasta, D.J."  
2  8  "Pagani, E.D."  
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loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_001006	2012-02-08	RCSB	"Create family"	
FAM_001006	2013-10-16	RCSB	"Initial release"	
#
