data_FAM_000405
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000405
_pdbx_reference_molecule_family.name            YM-254890
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000405   PRD_000482  
#
_pdbx_reference_molecule_related_structures.family_prd_id  FAM_000405
_pdbx_reference_molecule_related_structures.ordinal        1
_pdbx_reference_molecule_related_structures.citation_id    1
_pdbx_reference_molecule_related_structures.db_name        CCDC
_pdbx_reference_molecule_related_structures.db_accession   77587
_pdbx_reference_molecule_related_structures.db_code        GIHKOX10
_pdbx_reference_molecule_related_structures.name           " cyclo((beta-(N-propionyl-beta-hydroxyleucyloxy)-leucyl)-N,O-dimethylthreonyl-(N-acetyl-beta-hydroxyleucyl-C,O)-(3-phenyllactato-O,O')-(N-methyl-dehydroalanyl)-alanyl-(N-methylalanyl)), FR900359, seqres C7 LEU*!-THR*,LEU*,UND,ALA*-ALA-ALA*-, A2 LEU*,LEU*!"
_pdbx_reference_molecule_related_structures.formula        ?
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000405   PRD_000482   1     MeSH         YM254890
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000405   PRD_000482   1     PMID:20639466        function                  "specifically inhibits the GDP/GTP exchange reaction of alpha subunit of Gq protein (Galphaq) by inhibiting the GDP release from Galphaq"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000405   PRD_000482   1     1     PubMedCentral          Image                     http://www.ncbi.nlm.nih.gov/corecgi/tileshop/tileshop.fcgi?p=PMC3&id=559646&s=11&r=1&c=1
FAM_000405   PRD_000482   2     1     MeSH                   MeSH_Unique_ID            C475455
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  1989    ?  873    878    10.1039/P19890000873                  ?  "Structural studies of FR900359, a novel cyclic depsipeptide from Ardisia crenata sims(Myrsinaceae)"                                                          "J. Chem. Soc., Perkin Trans. 1"  
 2  2004  279  47438  47445  ?                              15339913  "A novel Galphaq/11-selective inhibitor"                                                                                                                      "J Biol Chem."  
 3  2005  280  36701  36707  ?                              16141214  " Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13"                      "J Biol Chem."  
 4  2007   21  782.5  ?      ?                                     ?  " A novel type of G protein inhibitor, YM-254890, acts as a Gq-specific guanine nucleotide dissociation inhibitor via the switch I region of Galpha subunit"  "The FASEB Journal"  
 5  2006   11  487    498    ?                              16629901  " Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells."                                     "Genes Cells."  
 6  2004   12  3125   3133   10.1016/j.bmc.2004.04.006      15158780  "YM-254890 analogues, novel cyclic depsipeptides with Gq/11 inhibitory activity from Chromobacterium sp. QS3666"                                              "Bioorganic & Medicinal Chemistry"  
 7  2006  536  154    161    10.1016/j.ejphar.2006.02.048          ?  "Effect of YM-254890, a specific Gq/11 inhibitor, on experimental peripheral arterial disease in rats"                                                        "European Journal of Pharmacology"  
 8  2006  148  61     69     ?                              16520742  " Biological properties of a specific Galpha q/11 inhibitor, YM-254890, on platelet functions and thrombus formation under high-shear stress."                "Br J Pharmacol."  
 9  2003   59  4533   4538   10.1016/S0040-4020(03)00680-X         ?  "Structure of YM-254890, a Novel Gq/11 Inhibitor from Chromobacterium sp. QS3666"                                                                             Tetrahedron  
10  2003   56  358    363    ?                              12817809  "YM-254890, a Novel Platelet Aggregation Inhibitor Produced by Chromobacterium sp. QS3666"                                                                    "J Antibiot (Tokyo)."  
11  2008   31  987    998    10.1291/hypres.31.987                 ?  " Angiotensin II-Induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves Gq/11, Ras, ERK, Src and Ets-1"                                      "Hypertension Research"  
12  2005  118  5625   5636   ?                              16306225  " CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation."              "J Cell Sci."  
13  1989    ?  873    878    10.1039/P19890000873                  ?  "Structural studies of FR900359, a novel cyclic depsipeptide from Ardisia crenata sims(Myrsinaceae)"                                                          "J. Chem. Soc., Perkin Trans. 1"  
14  1988   53  2820   28258  10.1021/jo00247a030                   ?  "Structure of FR900359, a Cyclic Depsipeptide from Ardisia crenata sims"                                                                                      "J. Org. Chem."  
15  2005   96  347    354    10.1016/j.jep.2004.09.037             ?  "The genus Ardisia: a novel source of health-promoting compounds and phytopharmaceuticals"                                                                    "Journal of Ethnopharmacology"  
16  2006  106  840    895    10.1021/cr040699h                     ?  "Plant Cyclopeptides"                                                                                                                                         "Chem. Rev."  
17  2009   17  42     54     10.1159/000186689                     ?  "Functions and Regulatory Mechanisms of Gq-Signaling Pathways"                                                                                                Neurosignals  
18  2006  147  S46    S55    ?                                     ?  "Heterotrimeric G-proteins: a short history"                                                                                                                  "British Journal of Pharmacology"  
19  2004   10  115    118    ?                              14994990  "A contribution to the nomenclature of depsipeptides"                                                                                                         "J Pept Sci."  
20  2004   11  1309   1332   ?                              15134522  "Chemistry and biology of cyclic depsipeptides of medicinal and biological interest."                                                                         "Curr Med Chem."  
21  2007  386  321    339    ?                              18604953  "Depsipeptide synthesis"                                                                                                                                      "Methods Mol Biol."  
22  2009   17  42     54     10.1159/000186689                     ?  "Functions and Regulatory Mechanisms of Gq-Signaling Pathways"                                                                                                Neurosignals  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1    1  "Miyamae, A."  
 1    2  "Fujioka, M."  
 1    3  "Koda, S."  
 1    4  "Morimoto, Y."  
 2    5  "Takasaki, J."  
 2    6  "Saito, T."  
 2    7  "Taniguchi, M."  
 2    8  "Kawasaki, T."  
 2    9  "Moritani, Y."  
 2   10  "Hayashi, K."  
 2   11  "Kobori, M."  
 3   12  "Orth, J.H."  
 3   13  "Lang, S."  
 3   14  "Taniguchi, M."  
 3   15  "Aktories, K."  
 4   16  "Nishimura, A."  
 4   17  "Sugawara, Y."  
 4   18  "Takasaki, J."  
 4   19  "Taniguchi, M."  
 4   20  "Mizuno, N."  
 4   21  "Itoh, H."  
 5   22  "Nishimura, A."  
 5   23  "Okamoto, M."  
 5   24  "Sugawara, Y."  
 5   25  "Mizuno, N."  
 5   26  "Yamauchi, J."  
 5   27  "Itoh, H."  
 6   28  "Taniguchi, M."  
 6   29  "Suzumuraa, K.-i."  
 6   30  "Nagaia, K."  
 6   31  "Kawasakia, T."  
 6   32  "Takasakia, J."  
 6   33  "Sekiguchia, M."  
 6   34  "Moritania, Y."  
 6   35  "Saitoa, T."  
 6   36  "Hayashia, K."  
 6   37  "Fujitaa, S."  
 6   38  "Tsukamotoa, S.-i."  
 6   39  "Suzukia, K.-i."  
 7   40  "Uemura, T."  
 7   41  "Takamatsu, H."  
 7   42  "Kawasaki, T."  
 7   43  "Taniguchi, M."  
 7   44  "Yamamoto, E."  
 7   45  "Tomura, Y."  
 7   46  "Uchida, W."  
 7   47  "Miyata, K."  
 8   48  "Uemura, T."  
 8   49  "Kawasaki, T."  
 8   50  "Taniguchi, M."  
 8   51  "Moritani, Y."  
 8   52  "Hayashi, K."  
 8   53  "Saito, T."  
 8   54  "Takasaki, J."  
 8   55  "Uchida, W."  
 8   56  "Miyata, K."  
 9   57  "Taniguchi, M."  
 9   58  "Suzumura, K."  
 9   59  "Nagai, K."  
 9   60  "Kawasaki, T."  
 9   61  "Saito, T."  
 9   62  "Takasaki, J."  
 9   63  "Suzuki, K."  
 9   64  "Fujita, S."  
 9   65  "Tsukamoto, S."  
10   66  "Taniguchi, M."  
10   67  "Nagai, K."  
10   68  "Arao, N."  
10   69  "Kawasaki, T."  
10   70  "Saito, T."  
10   71  "Moritani, Y."  
10   72  "Fujita, S."  
10   73  "Suzuki, K."  
10   74  "Tsukamoto, S."  
11   75  "Abe, K."  
11   76  "Nakashima, H."  
11   77  "Ishida, M."  
11   78  "Miho, N."  
11   79  "Sawano, M."  
11   80  "Soe, N.N."  
11   81  "Kurabayashi, M."  
11   82  "Chayama, K."  
11   83  "Yoshizumi, M."  
11   84  "Ishida, T."  
12   85  "Capra, V."  
12   86  "Ravasi, S."  
12   87  "Accomazzo, M.R."  
12   88  "Citro, S."  
12   89  "Grimoldi, M."  
12   90  "Abbracchio, M.P."  
12   91  "Rovati, G.E."  
13   92  "Miyamae, A."  
13   93  "Fujioka, M."  
13   94  "Koda, S."  
13   95  "Morimoto, Y."  
14   96  "Fujioka, M."  
14   97  "Koda, S."  
14   98  "Morimoto, Y."  
14   99  "Biemann, K."  
15  100  "Kobayashi, H."  
15  101  "de Mejia, E."  
16  102  "Tan, N.-H."  
16  103  "Zhou, J."  
17  104  "Mizuno, N."  
17  105  "Itoh, H."  
18  106  "Milligan, G."  
18  107  "Kostenis, E."  
19  108  "Filip, S.V."  
19  109  "Cavelier, F."  
20  110  "Sarabia, F."  
20  111  "Chammaa, S."  
20  112  "Ruiz, A.S."  
20  113  "Ortiz, L.M."  
20  114  "Herrera, F.J."  
21  115  "Stawikowski, M."  
21  116  "Cudic, P."  
22  117  "Mizuno, N."  
22  118  "Itoh, H."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000405	2012-02-08	RCSB	"Create family"	
FAM_000405	2013-10-16	RCSB	"Initial release"	
#
