data_FAM_000125
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000125
_pdbx_reference_molecule_family.name            Ac-Yvad-cho
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000125   PRD_000252  
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loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000125   PRD_000252   1     PubChem      Ac-Yvad-cho
FAM_000125   PRD_000252   2     PubChem      "Caspase Inhibitor I"
FAM_000125   PRD_000252   3     PubChem      Ac-Tyr-val-ala-asp-cho
FAM_000125   PRD_000252   4     PubChem      Ac-Tyr-Val-Ala-Asp-Aldehyde
FAM_000125   PRD_000252   5     PubChem      N-Acetyl-Tyr-Val-Ala-Glu-al
FAM_000125   PRD_000252   6     PubChem      AL013
FAM_000125   PRD_000252   7     PubChem      "ICE (CASPASE I) INHIBITOR I"
FAM_000125   PRD_000252   8     PubChem      "L 709049"
FAM_000125   PRD_000252   9     SciFinder    "L 709049"
FAM_000125   PRD_000252   10    PubChem      "3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxobutanoic acid"
FAM_000125   PRD_000252   11    http://www.mpbio.com Ac-Tyr-Val-Ala-Asp-Aldehyde
FAM_000125   PRD_000252   12    http://www.mpbio.com Ac-Tyr-Val-Ala-Asp-CHO
FAM_000125   PRD_000252   13    http://www.mpbio.com Ac-YVAD-CHO
FAM_000125   PRD_000252   14    MolPort      "3-(2-{2-[2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido}propanamido)-4-oxobutanoic acid"
FAM_000125   PRD_000252   15    ChEBI        "(R)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionylamino)-4-oxo-butyric acid"
FAM_000125   PRD_000252   16    PubChem      "IL-1beta Converting Enzyme (ICE) Inhibitor I"
FAM_000125   PRD_000252   17    PubChem      "(S)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionylamino)-4-oxo-butyric acid"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000125   PRD_000252   1     http://www.mpbio.com/ Function                  "A potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells."
FAM_000125   PRD_000252   2     PubChem              "Pharmacological action"  "Cysteine Proteinase Inhibitors"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000125   PRD_000252   1     1     PubChem                External_reference_ID     4339
FAM_000125   PRD_000252   2     1     Sigma                  External_reference_ID     A1085
FAM_000125   PRD_000252   3     1     MolPort                External_reference_ID     MolPort-003-939-868
FAM_000125   PRD_000252   4     1     CAS                    External_reference_ID     143313-51-3
FAM_000125   PRD_000252   5     2     CAS                    External_reference_ID     174063-88-8
FAM_000125   PRD_000252   6     1     ChemSpider             External_reference_ID     4186
FAM_000125   PRD_000252   7     1     ChemDB                 External_reference_ID     3967665
FAM_000125   PRD_000252   8     1     ChEBI                  External_reference_ID     150538
FAM_000125   PRD_000252   9     2     ChEBI                  External_reference_ID     287394
FAM_000125   PRD_000252   10    2     ChemSpider             External_reference_ID     18740399
FAM_000125   PRD_000252   11    2     PubChem                External_reference_ID     22849799
FAM_000125   PRD_000252   12    3     PubChem                External_reference_ID     5311139
FAM_000125   PRD_000252   13    3     ChEBI                  External_reference_ID     150856
FAM_000125   PRD_000252   14    1     BindingDB              External_reference_ID     10355
FAM_000125   PRD_000252   15    3     ChemSpider             External_reference_ID     4470665
FAM_000125   PRD_000252   16    1     Calbiochem             External_reference_ID     400010
FAM_000125   PRD_000252   17    1     Calbiochem             Image                     http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=400010
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000125	2012-02-08	RCSB	"Create family"	
FAM_000125	2013-10-16	RCSB	"Initial release"	
#
