data_FAM_001004
#
_pdbx_reference_molecule_family.family_prd_id   FAM_001004
_pdbx_reference_molecule_family.name            Chymostatin
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_001004   PRD_000558  
FAM_001004   PRD_000559  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_001004   PRD_000558   1     PMID:4792111 "N-[((S)-1-carboxy-2-phenylethyl)-carbamoyl]-alpha-[2-iminohexahydro-4(S)-pyrimidyl]-L-glycyl-L-leucyl-phenylalaninal."
FAM_001004   PRD_000558   2     PubChem
;(2S)-2-[[(1S)-1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid
;
FAM_001004   PRD_000558   3     http://www.gbiosciences.com/ResearchProducts/Chymostatin.aspx
;N-(Nalpha-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine)(capreomycidine = [S,S]-alpha-(2-Iminohexahydro-4-pyrimidyl)glycine)
;
FAM_001004   PRD_000558   4     http://www.gbiosciences.com/ResearchProducts/Chymostatin.aspx "N-[(S)-1-carboxy-isopentyl)-carbamoyl-alpha-(2-iminohexahydro-4(S)-pyrimidyl]-L-glycyl-L-phenylalaninal"
FAM_001004   PRD_000559   5     PubChem
;(2S)-2-[[(2S)-2-amino-2-[(6R)-2-amino-1,4,5,6-tetrahydropyrimidin-6-yl]acetyl]amino]-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-4-methylpentanamide
;
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_001004   PRD_000558   1     PubChem              Function                  "microbial alkaline proteinase inhibitor"
FAM_001004   PRD_000558   2     http://www.gbiosciences.com/ResearchProducts/Chymostatin.aspx Function                  "Inhibits serine proteases having a chymotrypsin-like specificity, including alpha, beta, gamma, and delta chymotrypsin, and most cysteine proteases including cathepsins B, H, L."
FAM_001004   PRD_000558   3     SigmaAldrich         Function
;Chymostatin is a mixture of several components, typically 79-89% chymostatin A, 12-17% chymostatin B and 5-15%chymostatin C.Chymostatin A: X=L-LeuChymostatin B: X=L-ValChymostatin C: X=L-IleChymostatin is a strong inhibitor of many proteinases, including chymotrypsin, chymotrypsin-like serineproteinases, chymases and lysosomal cysteine proteinases such as cathepsins B, H and L. It weaklyinhibits human leucocyte elastase. It is effective at a final concentration of 6-60 mg/mL (10-100 mM),although the working solution is not stable (the terminal aldehyde is subject to oxidation.) Chymostatin isoften included in "protease inhibitor cocktails", for plant extracts.Target: Cathepsin B, Cathepsin D, Cathepsin G, Chymotrypsin, alpha-, Papain, Cathepsin B/G, Chymotrypsin, Papain
;
FAM_001004   PRD_000559   4     PMID:11747435        Function                  "Inhibitor of SERINE-CARBOXYL PROTEINASE, EC:3.4.23.33"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_001004   PRD_000558   1     1     BindingDB              External_Reference_ID     50210112
FAM_001004   PRD_000558   2     1     ChEBI                  External_Reference_ID     510447
FAM_001004   PRD_000558   3     1     ChEMBL                 External_Reference_ID     247767
FAM_001004   PRD_000558   4     1     ChemIDplus             External_Reference_ID     070857497
FAM_001004   PRD_000558   5     1     ChemSpider             External_Reference_ID     391398
FAM_001004   PRD_000558   6     3     ChemSpider             External_Reference_ID     4450198
FAM_001004   PRD_000558   7     4     ChemSpider             External_Reference_ID     65292
FAM_001004   PRD_000558   8     1     KEGG                   KEGG_Compound_ID          C11308
FAM_001004   PRD_000558   9     1     LeadScope              External_Reference_ID     LS-161279
FAM_001004   PRD_000558   10    2     LeadScope              External_Reference_ID     LS-187745
FAM_001004   PRD_000558   11    1     PubChem                External_Reference_ID     443119
FAM_001004   PRD_000558   12    3     PubChem                External_Reference_ID     5287931
FAM_001004   PRD_000558   13    4     PubChem                External_Reference_ID     72355
FAM_001004   PRD_000558   14    1     CAS                    External_Reference_ID     9076-44-2
FAM_001004   PRD_000558   15    1     SigmaAldrich           URL                       http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/c7268pis.Par.0001.File.tmp/c7268pis.pdf
FAM_001004   PRD_000559   16    1     PubChem                External_Reference_ID     5287986
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_001004	2012-02-08	RCSB	"Create family"	
FAM_001004	2013-10-16	RCSB	"Initial release"	
#
