data_FAM_000134
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000134
_pdbx_reference_molecule_family.name            "APV peptide boronic acid inhibitor"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000134   PRD_000261  
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loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000134   PRD_000261   1     PDB          "N-tert-butyloxycarbonylalanylprolylvaline boronic acid"
FAM_000134   PRD_000261   2     PubChem      "trihydroxy-[(1R)-2-methyl-1-[[(2S)-1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]pyrrolidine-2-carbonyl]amino]propyl]boranuide"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000134   PRD_000261   1     PMID:3122831         Function                  "inhibitor of alpha lytic protease, EC: 3.4.21.12"
FAM_000134   PRD_000261   2     PMID:3122831         "Mechanism of action"     "The active-site serine forms a covalent, nearly tetrahedral adduct with the boronic acid moiety of the inhibitor."
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loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000134   PRD_000261   1     1     PubChem                External_reference_ID     5496789
FAM_000134   PRD_000261   2     1     ChemSpider             External_reference_ID     4593499
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000134	2012-02-08	RCSB	"Create family"	
FAM_000134	2013-10-16	RCSB	"Initial release"	
#
