data_FAM_000084
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000084
_pdbx_reference_molecule_family.name            Lantibiotic
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000084   PRD_000194  
FAM_000084   PRD_000195  
FAM_000084   PRD_000196  
FAM_000084   PRD_000197  
FAM_000084   PRD_000198  
FAM_000084   PRD_000199  
FAM_000084   PRD_000200  
#
_pdbx_reference_molecule_related_structures.family_prd_id  FAM_000084
_pdbx_reference_molecule_related_structures.ordinal        1
_pdbx_reference_molecule_related_structures.citation_id    29
_pdbx_reference_molecule_related_structures.db_name        CCDC
_pdbx_reference_molecule_related_structures.db_accession   ?
_pdbx_reference_molecule_related_structures.db_code        WOPCAF
_pdbx_reference_molecule_related_structures.name           " cysteinyl-(alpha-aminobutyryl)-phenylalanyl-(alpha-aminobutyryl)-leucyl-prolyl-glycyl-glycyl-glycyl-glycyl-valyl-cysteinyl-(alpha-aminobutyryl)-leucyl-(alpha-aminobutyryl)-(dehydroalanyl)-glutamyl-cysteinyl-isoleucine 2-sulfanylethenylamide methanol solvate hydrate, Mersacidin methanol solvate hydrate, seqres C9 CYS*!,GLY!-LEU-PRO-GLY-GLY-GLY-GLY-VAL-, C6 ALA!,CYS*!-LEU-CYS*-ALA*-GLU-, C2 CYS*-GLY!, A3 GLY!-PHE-GLY!, A2 ALA!-ILE, A2 CYS*!-CYS*!"
_pdbx_reference_molecule_related_structures.formula        "6(C80 H120 N20 O21 S4), 9(C H4 O), 58(H2 O)"
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000084   PRD_000194   1     PDB          ACTAGARDINE
FAM_000084   PRD_000194   2     SciFinder    "Antibiotic A 3802-IV-3"
FAM_000084   PRD_000194   3     SciFinder    Gardimycin
FAM_000084   PRD_000194   4     SciFinder    Actagardine
FAM_000084   PRD_000194   5     UniProt      Gardimycin
FAM_000084   PRD_000194   6     UniProt      "lantibiotic actagardine"
FAM_000084   PRD_000194   7     PubChem      Actagardine
FAM_000084   PRD_000194   8     PubChem      Gardimycin
FAM_000084   PRD_000194   9     PubChem      "AIDS 187911"
FAM_000084   PRD_000195   10    PDB          CINNAMYCIN
FAM_000084   PRD_000195   11    SciFinder    Lanthiopeptin
FAM_000084   PRD_000195   12    SciFinder    "Ro 09-0198"
FAM_000084   PRD_000195   13    SciFinder    "Cinnamycin, hydrochloride (9CI)"
FAM_000084   PRD_000195   14    UniProt      Lanthiopeptin
FAM_000084   PRD_000195   15    UniProt      "Lantibiotic Ro 09-0198"
FAM_000084   PRD_000195   16    PubChem      Lanthiopeptin
FAM_000084   PRD_000195   17    PubChem      "Ro 09-0198"
FAM_000084   PRD_000195   18    PubChem      "NSC 71936"
FAM_000084   PRD_000196   19    PDB          EPILANCIN
FAM_000084   PRD_000196   20    SciFinder    "L-Lysine, N-(2-hydroxy-1-oxopropyl)-L-alanyl-2,3-didehydroalanyl-L-isoleucyl-L-valyl-L-lysyl-(2Z)-2-amino-2-butenoyl-(2Z)-2-amino-2-butenoyl-L-isoleucyl-L-lysyl-L-alanyl-D-cysteinyl-L-lysyl-L-lysyl-L-leucyl-L-cysteinyl-L-arginylglycyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-cysteinylglycyl-L-cysteinyl-L-histidyl-L-phenylalanyl-(2Z)-2-amino-2-butenoylglycyl-L-lysyl-,cyclic (11->15),(19->22),(21->24)-tris(thioether)"
FAM_000084   PRD_000196   21    SciFinder    "L-Lysine, 2-hydroxypropanoyl-L-alanyl-2,3-didehydroalanyl-L-isoleucyl-L-valyl-L-lysyl-(2Z)-2-amino-2-butenoyl-(2Z)-2-amino-2-butenoyl-L-isoleucyl-L-lysyl-L-alanyl-D-cysteinyl-L-lysyl-L-lysyl-L-leucyl-L-cysteinyl-L-arginylglycyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-cysteinylglycyl-L-cysteinyl-L-histidyl-L-phenylalanyl-(2Z)-2-amino-2-butenoylglycyl-L-lysyl-,cyclic (12->16),(20->23),(22->25)-tris(thioether) (9CI)"
FAM_000084   PRD_000196   22    SciFinder    WO2005023852
FAM_000084   PRD_000196   23    SciFinder    "Epilancin 15X"
FAM_000084   PRD_000199   24    PDB          MERSACIDIN
FAM_000084   PRD_000199   25    SciFinder    "Mersacidin (9CI)"
FAM_000084   PRD_000200   26    PDB          NISIN
FAM_000084   PRD_000200   27    PubChem      NSC112903
FAM_000084   PRD_000200   28    SciFinder    "Nisin A"
FAM_000084   PRD_000200   29    SciFinder    "Nisin (8CI)"
FAM_000084   PRD_000200   30    SciFinder    Nisaplin
FAM_000084   PRD_000200   31    SciFinder    Nisin(1-34)
FAM_000084   PRD_000200   32    SciFinder    Nisitrol
FAM_000084   PRD_000200   33    SciFinder    Novasin
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000084   PRD_000194   1     NovelAntibiotics     Function                  Antibacterial
FAM_000084   PRD_000194   2     Bactibase            Function                  lantibiotic
FAM_000084   PRD_000194   3     Bactibase            Function                  "creates aqueous pores in membrane"
FAM_000084   PRD_000194   4     UniProt              Function                  "antibacterial activity against Gram-positive bacteria"
FAM_000084   PRD_000194   5     UniProt              Function                  "good antistreptococcal activity"
FAM_000084   PRD_000194   6     PMID:9219543         Function                  murein-biosynthesis-inhibitor
FAM_000084   PRD_000195   7     NovelAntibiotics     Function                  Antiviral
FAM_000084   PRD_000195   8     Bactibase            Function                  "enzyme inhibitor of phospholipase A2 and of angiotensin-converting enzyme"
FAM_000084   PRD_000195   9     Bactibase            Function                  "exhibits immunopotentiating and inhibitory activity against herpes simplex virus"
FAM_000084   PRD_000195   10    UniProt              Function                  "inhibitor of the enzymes phospholipase A2, and angiotensin-converting enzyme"
FAM_000084   PRD_000195   11    UniProt              Function                  "Shows inhibitory activities against herpes simplex virus and immunopotentiating activities"
FAM_000084   PRD_000196   12    UniProt              Function                  lantibiotic
FAM_000084   PRD_000199   13    Bactibase            Function                  "Interferes with bacterial peptidoglycan synthesis"
FAM_000084   PRD_000199   14    UniProt              Function                  "Interferes with bacterial peptidoglycan synthesis"
FAM_000084   PRD_000200   15    Bactibase            Function                  "forms pores on bacterial membrane"
FAM_000084   PRD_000200   16    UniProt              Function                  "Depolarizes bacterial membrane, initiates pore formation"
FAM_000084   PRD_000197   17    PMID:20578714        Structure                 "component alpha of 2 component lantibiotic lichenicidin"
FAM_000084   PRD_000198   18    PMID:20578714        Structure                 "component beta of 2 component lantibiotic lichenicidin"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000084   PRD_000194   1     1     CAS                    External_Reference_ID     59165-34-3
FAM_000084   PRD_000194   2     1     Beilstein              External_Reference_ID     90400059
FAM_000084   PRD_000194   3     1     NovelAntibiotics       External_Reference_ID     520189
FAM_000084   PRD_000194   4     1     Bactibase              External_Reference_ID     BAC012
FAM_000084   PRD_000194   5     1     UniProt                External_Reference_ID     P56650
FAM_000084   PRD_000194   6     1     PubChem                External_Reference_ID     16204841
FAM_000084   PRD_000194   7     1     MESH                   MESH_Unique_ID            C012993
FAM_000084   PRD_000195   8     1     CAS                    External_Reference_ID     110655-58-8
FAM_000084   PRD_000195   9     2     CAS                    External_Reference_ID     64045-98-3
FAM_000084   PRD_000195   10    1     NovelAntibiotics       External_Reference_ID     420146
FAM_000084   PRD_000195   11    1     Bactibase              External_Reference_ID     BAC010
FAM_000084   PRD_000195   12    1     UniProt                External_Reference_ID     P29827
FAM_000084   PRD_000195   13    1     PubChem                External_Reference_ID     16130216
FAM_000084   PRD_000195   14    1     ChemSpider             External_Reference_ID     17286654
FAM_000084   PRD_000195   15    1     ChemDB                 External_Reference_ID     4915928
FAM_000084   PRD_000195   16    1     MESH                   MESH_Unique_ID            C000485
FAM_000084   PRD_000195   17    1     RTECS                  External_Reference_ID     GE1925000
FAM_000084   PRD_000195   18    1     MDL                    External_Reference_ID     MFCD01770867
FAM_000084   PRD_000196   19    1     CAS                    External_Reference_ID     848036-24-8
FAM_000084   PRD_000196   20    1     Bactibase              External_Reference_ID     BAC145
FAM_000084   PRD_000196   21    1     UniProt                External_Reference_ID     Q57312
FAM_000084   PRD_000196   22    1     MESH                   MESH_Unique_ID            C500288
FAM_000084   PRD_000199   23    1     CAS                    External_Reference_ID     128104-18-7
FAM_000084   PRD_000199   24    1     Bactibase              External_Reference_ID     BAC014
FAM_000084   PRD_000199   25    1     UniProt                External_Reference_ID     P43683
FAM_000084   PRD_000199   26    1     PubChem                External_Reference_ID     16132433
FAM_000084   PRD_000199   27    1     ChemSpider             External_Reference_ID     17289091
FAM_000084   PRD_000199   28    1     MESH                   MESH_Unique_ID            C069959
FAM_000084   PRD_000199   29    1     "Orientations of Proteins in Membranes (OPM) database" External_Reference_ID     3.4.02.02
FAM_000084   PRD_000199   30    1     WikiPedia              URL                       http://en.wikipedia.org/wiki/Lantibiotics
FAM_000084   PRD_000200   31    1     CAS                    External_Reference_ID     1414-45-5
FAM_000084   PRD_000200   32    1     Merck                  External_Reference_ID     14:6564
FAM_000084   PRD_000200   33    1     Bactibase              External_Reference_ID     BAC047
FAM_000084   PRD_000200   34    1     UniProt                External_Reference_ID     P13068
FAM_000084   PRD_000200   35    1     PubChem                External_Reference_ID     16133879
FAM_000084   PRD_000200   36    1     MESH                   MESH_Unique_ID            D009561
FAM_000084   PRD_000200   37    1     MESH                   MESH_TreeNumber           D04.345.566.582
FAM_000084   PRD_000200   38    2     MESH                   MESH_TreeNumber           D12.644.641.582
FAM_000084   PRD_000200   39    3     MESH                   MESH_TreeNumber           D12.776.097.151.700
FAM_000084   PRD_000200   40    4     MESH                   MESH_TreeNumber           D12.776.543.695.110.700
FAM_000084   PRD_000200   41    1     WikiPedia              URL                       http://en.wikipedia.org/wiki/Nisin
FAM_000084   PRD_000199   42    1     PepBank                URL                       http://pepbank.mgh.harvard.edu/interactions/details/43292
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  1999   52  730    41     ?                                   10580386  "Ala(0)-actagardine, a new lantibiotic from cultures of Actinoplanes liguriae ATCC 31048"  "J Antibiot (Tokyo)"  
 2  1995  228  786    797    10.1111/j.1432-1033.1995.0786m.x           ?  "The Tetracyclic Lantibiotic Actagardine 1H-NMR and 13C-NMR Assignments and Revised Primary Structure"  "European Journal of Biochemistry"  
 3  2009   72  1126   1136   ?                                   19400806  " Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system"  "Mol Microbiol."  
 4  1991  199  411    415    ?                                    2070795  " Prepeptide sequence of cinnamycin (Ro 09-0198): the first structural gene of a duramycin-type lantibiotic."  "Eur. J. Biochem."  
 5  1990   43  1403   1412   ?                                    2125590  " Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin."  "J. Antibiot."  
 6  1989   42  837    845    ?                                    2544544  " Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin."  "J. Antibiot."  
 7  1996  119  226    230    ?                                    8882709  " Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1"  J.Biochem.(Tokyo)  
 8  2005  579  1917   1922   10.1016/j.febslet.2005.01.083              ?  " Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis"  "FEBS Letters"  
 9  1988  333  276    278    ?                                    2835685  " Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings."  Nature  
10  2001   25  285    308    ?                                   11348686  "Lantibiotics: Structure, biosynthesis and mode of action."  "FEMS Microbiol. Rev."  
11  2004    8  498    507    ?                                   15450492  "Post-translational modifications during lantibiotic biosynthesis"  "Curr. Opin. Chem. Biol."  
12  2004   11  963    967    ?                                   15361862  " The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics"  "Nature Struct. Mol. Biol."  
13  2006    5  321    323    10.1038/nrd2004                            ?  "Lipid II as a target for antibiotics"  "Nature Reviews Drug Discovery"  
14  1995  230  587    600    ?                                    7607233  " Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7 Cloning and characterisation of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7"  "Eur. J. Biochem."  
15  2010    ?  ?      ?      ?                                   20578714  " Isolation, Structure Elucidation, and Synergistic Antibacterial Activity of a Novel Two-Component Lantibiotic Lichenicidin from Bacillus licheniformis VK21"  Biochemistry  
16  2010   54  1498   1505   10.1128/AAC.00883-09                20100873  " Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence."  "Antimicrob Agents Chemother."  
17  2010   38  W647   W651   10.1093/nar/gkq365                  20462861  "BAGEL2: mining for bacteriocins in genomic data."  "Nucleic Acids Res."  
18  2010   76  2335   2344   10.1128/AEM.01790-09                20154110  " Identification and analysis of the biosynthetic gene cluster encoding the thiopeptide antibiotic cyclothiazomycin in Streptomyces hygroscopicus 10-22."  "Appl Environ Microbiol."  
19  2009   75  4427   4434   10.1128/AEM.00262-09                19429551  "Influence of Ca(2+) ions on the activity of lantibiotics containing a mersacidin-like lipid II binding motif."  "Appl Environ Microbiol."  
20  2009    4  e6788  ?      ?                                   19707558  "Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13."  "PLoS One."  
21  2009   75  5451   5460   ?                                   19561184  "Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins."  "Appl Environ Microbiol."  
22  2009  191  1480   1489   10.1128/JB.01343-08                 19114491  
; Role of conjugative elements in the evolution of the multidrug-resistant pandemic clone Streptococcus pneumoniaeSpain23F
 ST81.
;
  "J Bacteriol."  
23  2009   16  490    498    10.1016/j.chembiol.2009.03.011             ?  "Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin"  "Chemistry & Biology"  
24  2006  103  17243  17248  10.1073/pnas.0606088103             17085596  "Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic."  "Proc Natl Acad Sci U S A"  
25  2004   43  3049   3056   ?                                   15023056  "Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity."  Biochemistry  
26  2004    5  R77    ?      10.1186/gb-2004-5-10-r77            15461803  " Complete genome sequence of the industrial bacterium Bacillus licheniformis and comparisons with closely related Bacillus species."  "Genome Biol."  
27  2001  147  643    651    ?                                   11238971  "Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics."  Microbiology  
28  1996   69  171    184    ?                                    8775977  "Comparison of lantibiotic gene clusters and encoded proteins."  "Antonie Van Leeuwenhoek."  
29  2000   56  705    713    10.1107/S0907444900003711                  ?  "Ab initio structure determination of the lantibiotic mersacidin"  "Acta Crystallogr.,Sect.D:Biol.Crystallogr."  
30  1995   39  714    719    ?                                    7793878  " Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?"  "Antimicrobial Agents and Chemotherapy"  
31  1998   42  154    160    ?                                    9449277  "The Lantibiotic Mersacidin Inhibits Peptidoglycan Synthesis by Targeting Lipid II"  "Antimicrobial Agents and Chemotherapy"  
32  2008    8  186    ?      10.1186/1471-2180-8-186                ?  "The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus"  "BMC Microbiology"  
33  2009   16  490    498    10.1016/j.chembiol.2009.03.011         ?  "Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin"  "Chemistry & Biology"  
34  2009    4  865    874    10.1021/cb900194x                          ?  "Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin"  "ACS Chem. Biol."  
35  2006    5  321    323    10.1038/nrd2004                        ?  "Lipid II as a target for antibiotics"  "Nature Reviews Drug Discovery"  
36  1990   56  2551   2558   ?                                     184764  "Some chemical and physical properties of nisin, a small-protein antibiotic produced by Lactococcus lactis."  "Appl Environ Microbiol."  
37  1996   62  2966   2969   ?                                     168084  "Structure-activity relationships in the peptide antibiotic nisin: role of dehydroalanine 5."  "Appl Environ Microbiol."  
38  1986   59  2505   2508   10.1246/bcsj.59.2505                       ?  "Synthetic Study on Peptide Antibiotic Nisin. II. The Synthesis of Ring B"  "Bulletin of the Chemical Society of Japan"  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1    1  "Vertesy, L."  
 1    2  "Aretz, W."  
 1    3  "Bonnefoy, A."  
 1    4  "Ehlers, E."  
 1    5  "Kurz, M."  
 1    6  "Markus, A."  
 1    7  "Schiell, M."  
 1    8  "Vogel, M."  
 1    9  "Wink, J."  
 1   10  "Kogler, H."  
 2   11  "Zimmermann, N."  
 2   12  "Metzger, J.W."  
 2   13  "Jung, G"  
 3   14  "Boakes, S."  
 3   15  "Cortes, J."  
 3   16  "Appleyard, A.N."  
 3   17  "Rudd, B.A."  
 3   18  "Dawson, M.J."  
 4   19  "Kaletta, C."  
 4   20  "Entian, K.-D."  
 4   21  "Jung, G."  
 5   22  "Fredenhagen, A."  
 5   23  "Fendrich, G."  
 5   24  "Marki, F."  
 5   25  "Marki, W."  
 5   26  "Gruner, J."  
 5   27  "Raschdorf, F."  
 5   28  "Peter, H.H."  
 6   29  "Naruse, N."  
 6   30  "Tenmyo, O."  
 6   31  "Tomita, K."  
 6   32  "Konishi, M."  
 6   33  "Miyaki, T."  
 6   34  "Kawaguchi, H."  
 6   35  "Fukase, K."  
 6   36  "Wakamiya, T."  
 6   37  "Shiba, T."  
 7   38  "Hosoda, K."  
 7   39  "Ohya, M."  
 7   40  "Kohno, T."  
 7   41  "Maeda, T."  
 7   42  "Endo, S."  
 7   43  "Wakamatsu, K."  
 8   44  "Ekkelenkamp, M."  
 8   45  "Hanssen, M."  
 8   46  "Hsu, S.D."  
 8   47  "de Jong, A."  
 8   48  "Milatovic, D."  
 8   49  "Verhoef, J."  
 8   50  "van Nuland, N."  
 9   51  "Schnell, N."  
 9   52  "Entian, K.D."  
 9   53  "Schneider, U."  
 9   54  "Gotz, F."  
 9   55  "Zahner, H."  
 9   56  "Kellner, R."  
 9   57  "Jung, G."  
10   58  "McAuliffe, O."  
10   59  "Ross, R.P."  
10   60  "Hill, C."  
11   61  "Xie, L."  
11   62  "van der Donk, W.A."  
12   63  "Hsu, S.-T.D"  
12   64  "Breukink, E."  
12   65  "Tischenko, E."  
12   66  "Lutters, M.A.G."  
12   67  "de Kruijff, B."  
12   68  "Kaptein, R."  
12   69  "Bonvin, A.M.J.J."  
12   70  "van Nuland, N.A.J."  
13   71  "Breukink, E."  
13   72  "de Kruijff, B."  
14   73  "van de Kamp, M."  
14   74  "van den Hooven, H.W."  
14   75  "Konings, R.N.H."  
14   76  "Bierbaum, G."  
14   77  "Sahl, H.-G."  
14   78  "Kuipers, O.P."  
14   79  "Siezen, R.J."  
14   80  "de Vos, W.M."  
14   81  "Hilbers, C.W."  
14   82  "van de Ven, F.J.M."  
15   83  "Shenkarev, Z.O."  
15   84  "Finkina, E.I."  
15   85  "Nurmukhamedova, E.K."  
15   86  "Balandin, S.V."  
15   87  "Mineev, K.S."  
15   88  "Nadezhdin, K.D."  
15   89  "Yakimenko, Z.A."  
15   90  "Tagaev, A.A."  
15   91  "Temirov, Y.V."  
15   92  "Arseniev, A.S."  
15   93  "Ovchinnikova, T.V."  
16   94  "Majchrzykiewicz, J.A."  
16   95  "Lubelski, J."  
16   96  "Moll, G.N."  
16   97  "Kuipers, A."  
16   98  "Bijlsma, J.J."  
16   99  "Kuipers, O.P."  
16  100  "Rink, R."  
17  101  "de Jong, A."  
17  102  "van Heel, A.J."  
17  103  "Kok, J."  
17  104  "Kuipers, O.P."  
18  105  "Wang, J."  
18  106  "Yu, Y."  
18  107  "Tang, K."  
18  108  "Liu, W."  
18  109  "He, X."  
18  110  "Huang, X."  
18  111  "Deng, Z."  
19  112  "Bottiger, T."  
19  113  "Schneider, T."  
19  114  "Martinez, B."  
19  115  "Sahl, H.G."  
19  116  "Wiedemann, I."  
20  117  "Dischinger, J."  
20  118  "Josten, M."  
20  119  "Szekat, C."  
20  120  "Sahl, H.G."  
20  121  "Bierbaum, G."  
21  122  "Begley, M."  
21  123  "Cotter, P.D."  
21  124  "Hill, C."  
21  125  "Ross, R.P."  
22  126  "Croucher, N.J."  
22  127  "Walker, D."  
22  128  "Romero, P."  
22  129  "Lennard, N."  
22  130  "Paterson, G.K."  
22  131  "Bason, N.C."  
22  132  "Mitchell, A.M."  
22  133  "Quail, M.A."  
22  134  "Andrew, P.W."  
22  135  "Parkhill, J."  
22  136  "Bentley, S.D."  
22  137  "Mitchell, T.J."  
23  138  "Appleyard, A.N."  
23  139  "Choi, S."  
23  140  "Read, D.M."  
23  141  "Lightfoot, A."  
23  142  "Boakes, S."  
23  143  "Hoffmann, A."  
23  144  "Chopra, I."  
23  145  "Bierbaum, G."  
23  146  "Rudd, B.A.M."  
23  147  "Dawson, M.J."  
23  148  "Cortes, J."  
24  149  "McClerren, A.L."  
24  150  "Cooper, L.E."  
24  151  "Quan, C."  
24  152  "Thomas, P.M."  
24  153  "Kelleher, N.L."  
24  154  "van der Donk, W.A."  
25  155  "Martin, N.I."  
25  156  "Sprules, T."  
25  157  "Carpenter, M.R."  
25  158  "Cotter, P.D."  
25  159  "Hill, C."  
25  160  "Ross, R.P."  
25  161  "Vederas, J.C."  
26  162  "Rey, M.W."  
26  163  "Ramaiya, P."  
26  164  "Nelson, B.A."  
26  165  "Brody-Karpin, S.D."  
26  166  "Zaretsky, E.J."  
26  167  "Tang, M."  
26  168  "Lopez de Leon, A."  
26  169  "Xiang, H."  
26  170  "Gusti, V."  
26  171  "Clausen, I.G."  
26  172  "Olsen, P.B."  
26  173  "Rasmussen, M.D."  
26  174  "Andersen, J.T."  
26  175  "Jorgensen, P.L."  
26  176  "Larsen, T.S."  
26  177  "Sorokin, A."  
26  178  "Bolotin, A."  
26  179  "Lapidus, A."  
26  180  "Galleron, N."  
26  181  "Ehrlich, S.D."  
26  182  "Berka, R.M."  
27  183  "Holo, H."  
27  184  "Jeknic, Z."  
27  185  "Daeschel, M."  
27  186  "Stevanovic, S."  
27  187  "Nes, I.F."  
28  188  "Siezen, R.J."  
28  189  "Kuipers, O.P."  
28  190  "de Vos, W.M."  
29  191  "Schneider, T.R."  
29  192  "Karcher, J."  
29  193  "Pohl, E."  
29  194  "Lubini, P."  
29  195  "Sheldrick, G.M."  
30  196  "Brotz, H."  
30  197  "Bierbaum, G."  
30  198  "Markus, A."  
30  199  "Molitor, E."  
30  200  "Sahl, H.G."  
31  201  "Brotz, H."  
31  202  "Bierbaum, G."  
31  203  "Leopold, K."  
31  204  "Reynolds, P.E."  
31  205  "Sahl, H.-G."  
32  206  "Sass, P."  
32  207  "Jansen, A."  
32  208  "Szekat, C."  
32  209  "Sass, V."  
32  210  "Sahl, H.-G."  
32  211  "Bierbaum, G."  
33  212  "Appleyard, A.N."  
33  213  "Choi, S."  
33  214  "Read, D.M."  
33  215  "Lightfoot, A."  
33  216  "Boakes, S."  
33  217  "Hoffmann, A."  
33  218  "Chopra, I."  
33  219  "Bierbaum, G."  
33  220  "Rudd, B.A.M."  
33  221  "Dawson, M.J."  
33  222  "Cortes, J."  
34  223  "Oman, T.J."  
34  224  "van der Donk, W.A."  
35  225  "Breukink, E."  
35  226  "de Kruijff, B."  
36  227  "Liu, W."  
36  228  "Hansen, J.N."  
37  229  "Chan, W.C."  
37  230  "Dodd, H.M."  
37  231  "Horn, N."  
37  232  "Maclean, K."  
37  233  "Lian, L.Y."  
37  234  "Bycroft, B.M."  
37  235  "Gasson, M.J."  
37  236  "Roberts, G.C."  
38  237  "Fukase, K."  
38  238  "Wakamiya, T."  
38  239  "Shiba, T."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000084	2012-02-08	RCSB	"Create family"	
FAM_000084	2013-10-16	RCSB	"Initial release"	
#
