data_FAM_000064
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000064
_pdbx_reference_molecule_family.name            "Linear GRAMICIDIN"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000064   PRD_000150  
FAM_000064   PRD_000151  
FAM_000064   PRD_000152  
FAM_000064   PRD_000153  
FAM_000064   PRD_000154  
FAM_000064   PRD_000155  
FAM_000064   PRD_001127  
FAM_000064   PRD_001128  
FAM_000064   PRD_001131  
#
loop_
_pdbx_reference_molecule_related_structures.family_prd_id
_pdbx_reference_molecule_related_structures.ordinal
_pdbx_reference_molecule_related_structures.citation_id
_pdbx_reference_molecule_related_structures.db_name
_pdbx_reference_molecule_related_structures.db_accession
_pdbx_reference_molecule_related_structures.db_code
_pdbx_reference_molecule_related_structures.name
_pdbx_reference_molecule_related_structures.formula
FAM_000064  1  1  CCDC  ?  ZZZBRG    "Gramicidin A"              "C99 H140 N20 O32"  
FAM_000064  2  1  CCDC  ?  ZZZBRG01  "Gramicidin A"              "C99 H140 N20 O32"  
FAM_000064  3  1  CCDC  ?  ZZZBRJ    "Gramicidin A cesium salt"  "C99 H139 N20 O32 -, Cs +"  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000064   PRD_000150   1     PDB          GRAMICIDIN
FAM_000064   PRD_000150   2     Beilstein    HCO-L-Val-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2-CH2OH
FAM_000064   PRD_000150   3     PubChem      "Valyl gramicidin"
FAM_000064   PRD_000150   4     PubChem      "A Prestwick_799"
FAM_000064   PRD_000150   5     PubChem      "GRAMICIDIN A"
FAM_000064   PRD_000150   6     PubChem      1-garamicidin
FAM_000064   PRD_000150   7     PubChem      "Gramicidin A from Bacillus brevis"
FAM_000064   PRD_000150   8     PubChem      CPD-10415
FAM_000064   PRD_000151   9     PDB          GRAMICIDIN
FAM_000064   PRD_000151   10    PubChem      "Gramicidin B"
FAM_000064   PRD_000151   11    PubChem      CPD-10416
FAM_000064   PRD_000152   12    PDB          GRAMICIDIN
FAM_000064   PRD_000152   13    Merck        "amicidin D (Dubos)"
FAM_000064   PRD_000152   14    Merck        "linear gramicidins"
FAM_000064   PRD_000152   15    Merck        "Gramoderm (Schering)"
FAM_000064   PRD_000152   16    DrugBank     Neosporin
FAM_000064   PRD_000152   17    DrugBank     "Gramicidin D"
FAM_000064   PRD_000152   18    PubChem      "Neosporin Ophthalmic solution"
FAM_000064   PRD_000152   19    PubChem      Gramicidin
FAM_000064   PRD_000152   20    PubChem      Gramicidina
FAM_000064   PRD_000152   21    PubChem      Gramicidine
FAM_000064   PRD_000152   22    PubChem      Gramicidinum
FAM_000064   PRD_000152   23    DrugBank
;(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-formamido-3-methylbutanoyl]amino]acetyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide
;
FAM_000064   PRD_000150   24    PDB          "VALYL GRAMICIDIN"
FAM_000064   PRD_000151   25    PDB          "VAL-GRAMICIDIN B"
FAM_000064   PRD_000150   26    SciFinder    "Gramicidin A"
FAM_000064   PRD_000152   27    SciFinder    "Gramicidin D"
FAM_000064   PRD_000152   28    SciFinder    "Gramicidin Dubos"
FAM_000064   PRD_001127   29    PDB          "F1-Gramicidin A"
FAM_000064   PRD_001128   30    PDB          "F1-Gramicidin C"
FAM_000064   PRD_001131   31    PDB          "G15-Gramicidin A"
FAM_000064   PRD_000154   32    PDB          minigramicidin
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000064   PRD_000152   1     DrugBank             Function                  "For treatment of skin lesions, surface wounds and eye infections"
FAM_000064   PRD_000152   2     DrugBank             Function                  "particularly effective against gram-positive bacteria"
FAM_000064   PRD_000152   3     DrugBank             Function                  "highly hemolytic, it cannot be administered internally and so is used only on the skin as a lotion or ointment"
FAM_000064   PRD_000150   4     PMID:11570868        Function                  "channel-forming antibiotic"
FAM_000064   PRD_000151   5     PMID:11570868        Function                  "channel-forming antibiotic"
FAM_000064   PRD_000153   6     PMID:11570868        Function                  "channel-forming antibiotic"
FAM_000064   PRD_000154   7     DOI:10.1002/1521-3773(20021104)41:21<4062::AID-ANIE4062>3.0.CO;2-U Structure                 "D,L-Peptide Ion Channel"
FAM_000064   PRD_000155   8     PMID:15691331        Function                  "biological ion channel"
FAM_000064   PRD_001127   9     DOI:10.1021/bi0204286 Function                  "monovalent cation specific channel"
FAM_000064   PRD_001128   10    DOI:10.1021/bi0204286 Function                  "monovalent cation specific channel"
FAM_000064   PRD_001131   11    DOI:10.1021/bi0204286 Function                  "monovalent cation specific channel"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000064   PRD_000150   1     1     CAS                    External_Reference_ID     11029-61-1
FAM_000064   PRD_000150   2     1     Beilstein              External_Reference_ID     8194390
FAM_000064   PRD_000150   3     1     PubChem                External_Reference_ID     16132269
FAM_000064   PRD_000150   4     1     ChemSpider             External_Reference_ID     17288928
FAM_000064   PRD_000150   5     1     ChemBank               External_Reference_ID     3103749
FAM_000064   PRD_000150   6     1     KEGG                   KEGG_Compound_ID          C15830
FAM_000064   PRD_000150   7     1     MESH                   MESH_Unique_ID            D006096
FAM_000064   PRD_000150   8     1     MESH                   MESH_TreeNumber           D04.345.566.850.300
FAM_000064   PRD_000150   9     2     MESH                   MESH_TreeNumber           D12.644.641.850.300
FAM_000064   PRD_000150   10    3     MESH                   MESH_TreeNumber           D12.644.905.300
FAM_000064   PRD_000150   11    4     MESH                   MESH_TreeNumber           D12.776.543.695.221
FAM_000064   PRD_000151   12    1     Beilstein              External_Reference_ID     8194392
FAM_000064   PRD_000151   13    1     PubChem                External_Reference_ID     25244501
FAM_000064   PRD_000151   14    1     MESH                   MESH_Unique_ID            D006096
FAM_000064   PRD_000151   15    1     MESH                   MESH_TreeNumber           D04.345.566.850.300
FAM_000064   PRD_000151   16    2     MESH                   MESH_TreeNumber           D12.644.641.850.300
FAM_000064   PRD_000151   17    3     MESH                   MESH_TreeNumber           D12.644.905.300
FAM_000064   PRD_000151   18    4     MESH                   MESH_TreeNumber           D12.776.543.695.221
FAM_000064   PRD_000152   19    1     CAS                    External_Reference_ID     1393-88-0
FAM_000064   PRD_000152   20    1     Merck                  External_Reference_ID     14:532
FAM_000064   PRD_000152   21    1     Beilstein              External_Reference_ID     10244855
FAM_000064   PRD_000152   22    1     DrugBank               External_Reference_ID     DB00027
FAM_000064   PRD_000152   23    1     PubChem                External_Reference_ID     16130140
FAM_000064   PRD_000152   24    1     ChemSpider             External_Reference_ID     17286916
FAM_000064   PRD_000152   25    1     MESH                   MESH_Unique_ID            D006096
FAM_000064   PRD_000152   26    1     MESH                   MESH_TreeNumber           D04.345.566.850.300
FAM_000064   PRD_000152   27    2     MESH                   MESH_TreeNumber           D12.644.641.850.300
FAM_000064   PRD_000152   28    3     MESH                   MESH_TreeNumber           D12.644.905.300
FAM_000064   PRD_000152   29    4     MESH                   MESH_TreeNumber           D12.776.543.695.221
FAM_000064   PRD_000152   30    1     WikiPedia              URL                       http://en.wikipedia.org/wiki/Gramicidin
#
_citation.id                       1
_citation.year                     1978
_citation.journal_volume           121
_citation.page_first               41
_citation.page_last                54
_citation.pdbx_database_id_DOI     10.1016/0022-2836(78)90261-9
_citation.pdbx_database_id_PubMed  77905
_citation.title                    "Helical channels in crystals of gramicidin A and of a cesium--gramicidin A complex: an x-ray diffraction study."
_citation.journal_abbrev           "J Mol Biol."
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
1  1  "Koeppe, R.E."  
1  2  "Hodgson, K.O."  
1  3  "Stryer, L."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000064	2012-02-08	RCSB	"Create family"	
FAM_000064	2013-10-16	RCSB	"Initial release"	
#
