data_FAM_000123
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000123
_pdbx_reference_molecule_family.name            "Ac-VTbLQcmph inhibitor"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000123   PRD_000250  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000123   PRD_000250   1     PDB          acetyl-valyl-(O-benzyloxy)threonyl-leucyl-ketomethyl(cycloglutamine)-phthalhydrazide
FAM_000123   PRD_000250   2     PDB          Ac-VTbLQcmph
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000123   PRD_000250   1     PMID:17599357        function                  "inhibitor of Replicase polyprotein 1ab (pp1ab), EC: 3.4.22.-,"
FAM_000123   PRD_000250   2     PMID:17599357        "Mechanism of action"     "form an unusual thiiranium ring with the nucleophilic sulfur atom of Cys145, trapping the enzyme's catalytic residues in configurations similar to the intermediate states"
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000123	2012-02-08	RCSB	"Create family"	
FAM_000123	2013-10-16	RCSB	"Initial release"	
#
