data_FAM_000182
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000182
_pdbx_reference_molecule_family.name            dipeptide-fluoromethylketone
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000182   PRD_000312  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000182   PRD_000312   1     PDB          N~2~-(morpholin-4-ylcarbonyl)-N-[(1S)-2-oxo-1-(2-phenylethyl)propyl]-L-leucinamide
FAM_000182   PRD_000312   2     PubChem      N-[(2S)-1-[[(3S)-1-fluoro-2-oxo-5-phenylpentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide
FAM_000182   PRD_000312   3     PubChem      Mu-Leu-Homophe-FMK
FAM_000182   PRD_000312   4     PubChem      Mu-Leu-Homophe-Fluoromethylketone
FAM_000182   PRD_000312   5     PubChem      N-[1-[(1-fluoro-2-oxo-5-phenylpentan-3-yl)amino]-4-methyl-1-oxopentan-2-yl]morpholine-4-carboxamide
FAM_000182   PRD_000312   6     PubChem      Mu-L-HomoPhe-FMK
FAM_000182   PRD_000312   7     PubChem      FK040
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000182   PRD_000312   1     DOI:10.2210/pdb1ewp/pdb Function                  "inhibitor of Cruzain, EC: 3.4.22.51"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000182   PRD_000312   1     1     PubChem                External_reference_ID     25108695
FAM_000182   PRD_000312   2     2     PubChem                External_reference_ID     44135226
FAM_000182   PRD_000312   3     1     "MP-BioChemicals http://www.mpbio.com/" External_reference_ID     FK040
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
1  2003  47   154   160  10.1128/AAC.47.1.154-160.2003  ?  
; Structure-Activity Relationships for Inhibition of Cysteine Protease
 Activity and Development of Plasmodium falciparum by Peptidyl Vinyl Sulfones
;
  "Antimicrob Agents Chemother."  
2  2010  30   136   167  10.1002/med.20163              ?  "Falcipain-2 inhibitors"  "Medicinal Research Reviews"  
3  2007  12  1257  1267  10.1007/s10495-007-0052-1      ?  "Lysosomal and mitochondrial pathways in miltefosine-induced apoptosis in U937 cells"  Apoptosis  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
1   1  "Shenai, B.R."  
1   2  "Lee, B.J."  
1   3  "Alvarez-Hernandez, A."  
1   4  "Chong, P.Y."  
1   5  "Emal, C.D."  
1   6  "Neitz, R.J."  
1   7  "Roush, W.R."  
1   8  "Rosenthal, P.J."  
2   9  "Ettari, R."  
2  10  "Bova, F."  
2  11  "Zappala, M."  
2  12  "Grasso, S."  
2  13  "Micale, N."  
3  14  "Paris, C."  
3  15  "Bertoglio, J."  
3  16  "Breard, J."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000182	2012-02-08	RCSB	"Create family"	
FAM_000182	2013-10-16	RCSB	"Initial release"	
#
