data_FAM_000162
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000162
_pdbx_reference_molecule_family.name            "Leu-hydroxyethylene isostere containing INHIBITOR"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000162   PRD_000289  
FAM_000162   PRD_000290  
FAM_000162   PRD_000291  
FAM_000162   PRD_000292  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000162   PRD_000289   1     PDB          OM00-3
FAM_000162   PRD_000289   2     Scifinder
;L-Phenylalanine, L-alpha-glutamyl-L-leucyl-L-alpha-aspartyl-(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl-L-valyl-L-alpha-glutamyl-
;
FAM_000162   PRD_000289   3     PubChem      OM-00-3
FAM_000162   PRD_000289   4     PubChem      "(4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(2S)-2-amino-4-carboxybutanamido]-4-methylpentanamido]-3-carboxypropanamido]-4-hydroxy-2,7-dimethyloctanamido]-3-methylbutanamido]-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl} butanoic acid"
FAM_000162   PRD_000289   5     PubChem
;(4S)-4-amino-5-[[(2S)-1-[[(2S)-4-hydroxy-1-[[(4S,5S,7R)-5-hydroxy-8-[[(2S)-1-[[(2S)-5-hydroxy-1-[[(2S)-1-hydroxy-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-2,7-dimethyl-8-oxooctan-4-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
;
FAM_000162   PRD_000290   6     PubChem      Glu-Val-Asn-Leu-Ala-Ala-Glu-Phe
FAM_000162   PRD_000290   7     PubChem      "Glu-Val-Asn-Leu-Y-Ala-Ala-Glu-Phe, Y denotes replacement of CONH by (S)-CH(OH)CH2]"
FAM_000162   PRD_000290   8     SciFinder    "L-Phenylalanine, L-alpha-glutamyl-L-valyl-L-asparaginyl-(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl-L-alanyl-L-alpha-glutamyl-"
FAM_000162   PRD_000291   9     PubChem
;(1R,2R)-2-{(1S,2S)-2-[(S)-2-((S)-2-ACETYLAMINO-4-METHYL-PENTANOYLAMINO)-4-METHYLSULFANYL-BUTYRYLAMINO]-1-HYDROXY-4-METHYL-PENTYL}-4-OXO-CYCLOPENTANECARBOXYLIC ACID ((S)-1-BUTYLCARBAMOYL-2-METHYL-PROPYL)-AMIDE
;
FAM_000162   PRD_000291   10    PubChem
;(2R,3R)-2-((S)-2-{(S)-2-[2-((S)-Acetylamino)-4-methyl-pentanoylamino]-4-methylsulfanyl-1-oxo-butylamino}-1-hydroxy-4-methyl-pentyl)-4-oxo-cyclopentanecarboxylic acid [1-((S)-butylcarbamoyl)-2-methyl-propyl]-amide
;
FAM_000162   PRD_000292   11    PubChem
;(S)-4-AMINO-4-{(S)-1-[(S)-2-CARBAMOYL-1-((S)-1-{(S)-[(1R,2R)-2-((S)-1-CARBOXY-ETHYLCARBAMOYL)-CYCLOPENTYL]-HYDROXY-METHYL}-3-METHYL-BUTYLCARBAMOYL)-ETHYLCARBAMOYL]-2-METHYL-PROPYLCARBAMOYL}-BUTYRIC ACID
;
FAM_000162   PRD_000292   12    PubChem
;4-Amino-4-{(S,S)-1-[(S)-2-carbamoyl-1-(1-{(S)-[(1R,5R)-2-(1-carboxy-ethylcarbamoyl)-cyclopentyl]-(S)-hydroxy-methyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-butyric acid4-Amino-4-{(S,S)-1-[(S)-2-carbamoyl-1-(1-{(S)-[(1R,5R)-2-(1-carboxy-ethylcarbamoyl)-1-methyl-cyclopentyl]-(S)-hydroxy-methyl}-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-butyric acid
;
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000162   PRD_000289   1     PMID:12749695        Function                  "beta-secretase inhibitor"
FAM_000162   PRD_000290   2     PMID:11021803        Function                  "inhibitor of MEMAPSIN 2, EC: 3.4.23.46"
FAM_000162   PRD_000291   3     PMID:16078837        Function                  "inhibitor of beta-secretase 1, EC: 3.4.23.46"
FAM_000162   PRD_000292   4     PMID:16078837        Function                  "inhibitor of beta-secretase 1, EC: 3.4.23.46"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000162   PRD_000289   1     1     ChEBI                  External_reference_ID     491857
FAM_000162   PRD_000289   2     1     ChemSpider             External_reference_ID     394264
FAM_000162   PRD_000289   3     2     PubChem                External_reference_ID     44305509
FAM_000162   PRD_000289   4     2     ChEBI                  External_reference_ID     200570
FAM_000162   PRD_000289   5     2     PubChem                External_reference_ID     447068
FAM_000162   PRD_000290   6     1     ChemSpider             External_reference_ID     178515
FAM_000162   PRD_000290   7     1     PubChem                External_reference_ID     206031
FAM_000162   PRD_000290   8     1     ChemIDplus             External_reference_ID     314266767
FAM_000162   PRD_000290   9     1     CAS                    External_reference_ID     314266-76-7
FAM_000162   PRD_000290   10    1     MESH                   External_reference_ID     C414614
FAM_000162   PRD_000291   11    1     PubChem                External_reference_ID     5494410
FAM_000162   PRD_000291   12    1     BindingDB              External_reference_ID     16057
FAM_000162   PRD_000291   13    1     ChEMBL                 External_reference_ID     191129
FAM_000162   PRD_000291   14    1     ChemSpider             External_reference_ID     4591860
FAM_000162   PRD_000292   15    1     PubChem                External_reference_ID     5494406
FAM_000162   PRD_000292   16    1     BindingDB              External_reference_ID     16051
FAM_000162   PRD_000292   17    1     ChEMBL                 External_reference_ID     191122
FAM_000162   PRD_000292   18    1     ChemSpider             External_reference_ID     4591856
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000162	2012-02-08	RCSB	"Create family"	
FAM_000162	2013-10-16	RCSB	"Initial release"	
#
