data_FAM_000132
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000132
_pdbx_reference_molecule_family.name            "aspartate aldehyde containing tetrapeptide inhibitors"
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000132   PRD_000241  
FAM_000132   PRD_000259  
FAM_000132   PRD_000282  
FAM_000132   PRD_000284  
FAM_000132   PRD_000293  
FAM_000132   PRD_000300  
FAM_000132   PRD_000301  
FAM_000132   PRD_000976  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000132   PRD_000293   1     PDB          AC-ESMD-CHO
FAM_000132   PRD_000293   2     Scifinder    "L-Methioninamide, N-acetyl-L-alpha-glutamyl-L-seryl-N-[(1S)-2-carboxy-1-formylethyl]-"
FAM_000132   PRD_000293   3     PubChem      "(4S)-4-acetamido-5-[[(2S)-3-hydroxy-1-[[(2S)-1-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid"
FAM_000132   PRD_000282   4     Scifinder    "L-Leucinamide, N-acetyl-L-alpha-aspartyl-L-asparaginyl-N-[(1S)-2-carboxy-1-formylethyl]-"
FAM_000132   PRD_000282   5     PubChem      Ac-DNLD-CHO
FAM_000132   PRD_000282   6     PubChem      "Caspase-3/7 Inhibitor"
FAM_000132   PRD_000282   7     InhibitorSourceBook "Caspase-3/7 Inhibitor II"
FAM_000132   PRD_000282   8     InhibitorSourceBook Ac-DNLD-CHO
FAM_000132   PRD_000284   9     PDB          AC-DQMD-CHO
FAM_000132   PRD_000284   10    Scifinder    "L-Methioninamide, N-acetyl-L-alpha-aspartyl-L-glutaminyl-N-[(1S)-2-carboxy-1-formylethyl]-"
FAM_000132   PRD_000284   11    PubChem      "(3S)-3-acetamido-4-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-oxobutanoic acid"
FAM_000132   PRD_000284   12    PubChem      "(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-hydroxy-4-oxobutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]butanedioic acid"
FAM_000132   PRD_000300   13    Scifinder    "L-Prolinamide, N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-"
FAM_000132   PRD_000300   14    PubChem      Ac-IEPD-CHO
FAM_000132   PRD_000300   15    PubChem      "Granzyme B Inhibitor IV"
FAM_000132   PRD_000300   16    PubChem      "Caspase-8 inhibitor III"
FAM_000132   PRD_000300   17    InhibitorSourceBook Ac-IEPD-CHO
FAM_000132   PRD_000300   18    InhibitorSourceBook "Caspase-8 inhibitor III"
FAM_000132   PRD_000300   19    PubChem      "(4S)-4-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-5-[2-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-oxopentanoic acid"
FAM_000132   PRD_000300   20    InhibitorSourceBook Ac-Ile-Glu-Pro-Asp-CHO
FAM_000132   PRD_000301   21    PDB          Ac-IETD-CHO
FAM_000132   PRD_000301   22    Scifinder    "L-Threoninamide, N-acetyl-L-isoleucyl-L-alpha-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-(9CI)"
FAM_000132   PRD_000301   23    PubChem      "Caspase-8 Inhibitor I"
FAM_000132   PRD_000301   24    PubChem      "Granzyme B Inhibitor II"
FAM_000132   PRD_000301   25    eMolecules   Ac-Ile-Glu-Thr-Asp-Aldehyde
FAM_000132   PRD_000301   26    eMolecules   Ac-Ile-Glu-Thr-Asp-CHO
FAM_000132   PRD_000301   27    eMolecules   N-Acetyl-Ile-Glu-Thr-Asp-al
FAM_000132   PRD_000301   28    InhibitorSourceBook "Caspase-8 Inhibitor 1"
FAM_000132   PRD_000301   29    InhibitorSourceBook Ac-Ile-Glu-Thr-Asp-CHO
FAM_000132   PRD_000301   30    PubChem      "(4S)-4-[[(2S,3S)-2-acetamido-3-methylpentanoyl]amino]-5-[[(2S,3S)-3-hydroxy-1-[[(2S)-4-hydroxy-1,4-dioxobutan-2-yl]amino]-1-oxobutan-2-yl]amino]-5-oxopentanoic acid"
FAM_000132   PRD_000301   31    PubChem      Ac-IETD-CHO
FAM_000132   PRD_000301   32    PubChem      Ac-Ile-Glu-Thr-Asp-CHO
FAM_000132   PRD_000301   33    PubChem      Ac-Ile-Glu-Thr-Asp-Aldehyde
FAM_000132   PRD_000241   34    PDB          "N-acetyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-aspartic aldehyde"
FAM_000132   PRD_000241   35    PDB          Ac-LDESD-cho
FAM_000132   PRD_000241   36    InhibitorSourceBook "Caspase-2 Inhibitor II"
FAM_000132   PRD_000241   37    PubMed       acetyl-Leu-Asp-Glu-Ser-Asp-aldehyde
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000132   PRD_000282   1     InhibitorSourceBook  Function                  "tetrapeptidyl aldehyde that acts as an active site binding inhibitor of caspases-3 and -7"
FAM_000132   PRD_000282   2     InhibitorSourceBook  Function                  "activity against Camptothecin and anti-Fas-mediated apoptosis in Jurkat T cells"
FAM_000132   PRD_000284   3     PMID:17697120        Function                  "CASPASE-7 INHIBITOR"
FAM_000132   PRD_000293   4     PMID:17697120        Function                  "CASPASE-7 Inhibitor"
FAM_000132   PRD_000300   5     InhibitorSourceBook  Function                  "Reversible inhibitor of granzyme B and caspase-8"
FAM_000132   PRD_000301   6     InhibitorSourceBook  Function                  "Inhibitor of granzyme B, caspase-8, caspase-1, caspase-6, and caspase-10"
FAM_000132   PRD_000301   7     MPbiochemicals       Function                  "A potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM)"
FAM_000132   PRD_000241   8     InhibitorSourceBook  Function                  "cell-permeable and irreversible inhibitor of caspase-2"
FAM_000132   PRD_000259   9     PMID:17697120        Function                  "inhibitor of Caspase 7, EC: 3.4.22.60"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000132   PRD_000293   1     1     PubMed                 External_reference_ID     11398034
FAM_000132   PRD_000293   2     1     ChemSpider             External_reference_ID     9572934
FAM_000132   PRD_000282   3     1     Beilstein              External_reference_ID     10045742
FAM_000132   PRD_000282   4     1     PubChem                External_reference_ID     10458686
FAM_000132   PRD_000282   5     1     ChemSpider             External_reference_ID     8634100
FAM_000132   PRD_000282   6     1     CAS                    External_reference_ID     775289-20-8
FAM_000132   PRD_000282   7     1     Calbiochem             External_reference_ID     218832
FAM_000132   PRD_000284   8     1     PubChem                External_reference_ID     9984584
FAM_000132   PRD_000284   9     1     ChemSpider             External_reference_ID     8160174
FAM_000132   PRD_000284   10    2     PubChem                External_reference_ID     10460203
FAM_000132   PRD_000284   11    2     ChemSpider             External_reference_ID     8635616
FAM_000132   PRD_000300   12    1     PubChem                External_reference_ID     16760476
FAM_000132   PRD_000300   13    1     InhibitorSourceBook    External_reference_ID     368056
FAM_000132   PRD_000300   14    1     CAS                    External_reference_ID     352520-90-2
FAM_000132   PRD_000300   15    1     InhibitorSourceBook    Image                     http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=368056
FAM_000132   PRD_000301   16    1     MeSH                   MeSH_Unique_ID            C401206
FAM_000132   PRD_000301   17    1     PubChem                External_reference_ID     16760475
FAM_000132   PRD_000301   18    1     ChemSpider             External_reference_ID     9641038
FAM_000132   PRD_000301   19    1     ChemDB                 External_reference_ID     9749449
FAM_000132   PRD_000301   20    1     InhibitorSourceBook    External_reference_ID     368055
FAM_000132   PRD_000301   21    1     CAS                    External_reference_ID     191338-86-0
FAM_000132   PRD_000301   22    1     eMolecules             URL                       http://www.emolecules.com/cgi-bin/more?vid=27274825
FAM_000132   PRD_000301   23    1     InhibitorSourceBook    Image                     http://structuresearch.merck-chemicals.com/cgi-bin/getStructureImage.pl?owner=EMD&unit=BIO&product=368055
FAM_000132   PRD_000301   24    1     MPbiochemicals         External_reference_ID     AL012
FAM_000132   PRD_000301   25    2     PubChem                External_reference_ID     44135117
FAM_000132   PRD_000301   26    1     ChEBI                  External_reference_ID     598855
FAM_000132   PRD_000301   27    2     ChemSpider             External_reference_ID     9641038
FAM_000132   PRD_000301   28    3     PubChem                External_reference_ID     11466200
FAM_000132   PRD_000301   29    1     BindingDB              External_reference_ID     10357
FAM_000132   PRD_000241   30    1     InhibitorSourceBook    External_reference_ID     218814
FAM_000132   PRD_000241   31    1     PubChem                External_reference_ID     447969
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000132	2012-02-08	RCSB	"Create family"	
FAM_000132	2013-10-16	RCSB	"Initial release"	
#
