data_FAM_000411
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000411
_pdbx_reference_molecule_family.name            quinoxaline
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000411   PRD_000488  
FAM_000411   PRD_000491  
FAM_000411   PRD_000492  
#
loop_
_pdbx_reference_molecule_related_structures.family_prd_id
_pdbx_reference_molecule_related_structures.ordinal
_pdbx_reference_molecule_related_structures.citation_id
_pdbx_reference_molecule_related_structures.db_name
_pdbx_reference_molecule_related_structures.db_accession
_pdbx_reference_molecule_related_structures.db_code
_pdbx_reference_molecule_related_structures.name
_pdbx_reference_molecule_related_structures.formula
FAM_000411   1   2  CCDC  ?  CULVUA    "Triostin A isoamyl acetate solvate, seqres C5 ALA-CYS*!,CYS*!-VAL*,SER*- C5 CYS*!-VAL*,SER*-ALA-CYS*!,"                                    "C50 H62 N12 O12 S2, 2(C7 H14 O2)"  
FAM_000411   2   3  CCDC  ?  CULVUA10  "Triostin A isoamyl acetate solvate, seqres C5 ALA-CYS*!,CYS*!-VAL*,SER*- C5  CYS*!-VAL*,SER*-ALA-CYS*!,"                                   "C50 H62 N12 O12 S2, 2(C7 H14 O2)"  
FAM_000411   3   3  CCDC  ?  ZILGOQ    "Triostin C  chloroform solvate hydrate, seqres C5 ALA-CYS*!,CYS*!-LEU*,SER*- C5 CYS*!-LEU*,SER*-ALA-CYS*!,"                                "C54 H70 N12 O12 S2, 0.67(C H Cl3), 0.67(H2 O)"  
FAM_000411   4   3  CCDC  ?  ZILHAD    "Triostin A hydrochloride dimethylformamide solvate, seqres C5 ALA-CYS*!,CYS*!-VAL*,SER*- C5 CYS*!-VAL*,SER*-ALA-CYS*!,"                    "C50 H63 N12 O12 S2 +, Cl -, 2(C3 H7 N O)"  
FAM_000411   5   4  CCDC  ?  TANDEM30  "Des-N-tetramethyltriostin A dodecahydrate, Tandem dodecahydrate"                                                                           "C46 H54 N12 O12 S2, 12(H2 O)"  
FAM_000411   6   4  CCDC  ?  BICKON    "Des-N-tetramethyltriostin A tetradecahydrate"                                                                                              "C46 H54 N12 O12 S2, 14(H2 O)"  
FAM_000411   7   5  CCDC  ?  TANDEM20  "des-N-Tetramethyl-triostin A dodecahydrate"                                                                                                "C46 H54 N12 O12 S2, 12(H2 O)"  
FAM_000411   8  40  CCDC  ?  ZILGIK    " Echinomycin bis(quinoline) acetone solvate hydrate, Echinomycin 2QN, seqres C5 ALA-CYS*!,CYS*!-VAL*,SER*- C5 CYS*!-VAL*,SER*-ALA-CYS*!,"  "C53 H66 N10 O12 S2, 2.5(C3 H6 O), 2.5(H2 O)"  
FAM_000411   9  42  CCDC  ?  TANDEM    "Des-N-tetramethyl-triostin A dodecahydrate"                                                                                                "C46 H54 N12 O12 S2, 12(H2 O)"  
FAM_000411  10  43  CCDC  ?  TMTRST    "Des-N-tetramethyl-triostin A methanol solvate hydrate"                                                                                     "C46 H54 N12 O12 S2, 2(C H4 O), x(H2 O)"  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000411   PRD_000488   1     PDB          TRIOSTIN
FAM_000411   PRD_000488   2     SciFinder    "Triostin A"
FAM_000411   PRD_000488   3     SciFinder    "NSC 244425"
FAM_000411   PRD_000488   4     Merck        Triostins
FAM_000411   PRD_000488   5     Beilstein    dilactone
FAM_000411   PRD_000488   6     PubChem      "Triostin A"
FAM_000411   PRD_000488   7     PubChem      NSC2444425
FAM_000411   PRD_000488   8     PubChem      NCI60_001953
FAM_000411   PRD_000488   9     PubChem      B100928K382
FAM_000411   PRD_000488   10    ChemSpider   "Triostin A"
FAM_000411   PRD_000491   11    PDB          ECHINOMYCIN
FAM_000411   PRD_000491   12    SciFinder    "Antibiotic A 654I"
FAM_000411   PRD_000491   13    Merck        "Quinomycin A"
FAM_000411   PRD_000491   14    Beilstein    "Quinomycin A"
FAM_000411   PRD_000491   15    Beilstein    Levomycin
FAM_000411   PRD_000491   16    KEGG         "Quinomycin A"
FAM_000411   PRD_000491   17    PubChem      "Quinomycin A"
FAM_000411   PRD_000491   18    ChemSpider   "Antibiotic C638-8"
FAM_000411   PRD_000491   19    ChemSpider   "Crystalline Antibiotic C 638-8"
FAM_000411   PRD_000491   20    ChemSpider   "Echinomycin A"
FAM_000411   PRD_000491   21    ChemSpider   Levomycin
FAM_000411   PRD_000491   22    ChemSpider   "Quinomycin A (9CI)"
FAM_000411   PRD_000491   23    ChemSpider   "SK 302B"
FAM_000411   PRD_000491   24    ChemBank     "echinomycin A"
FAM_000411   PRD_000491   25    ChemBank     levomycin
FAM_000411   PRD_000491   26    ChemBank     "quinomycin A"
FAM_000411   PRD_000491   27    ChemBank     "SK 302B"
FAM_000411   PRD_000491   28    ChemBank     "S-426-S (lepetit)"
FAM_000411   PRD_000491   29    BioAustralis "Quinomycin A"
FAM_000411   PRD_000491   30    BioAustralis Actinoleukin
FAM_000411   PRD_000491   31    BioAustralis "Antibiotic 1491"
FAM_000411   PRD_000491   32    BioAustralis "Antibiotic 59266"
FAM_000411   PRD_000491   33    BioAustralis "Antibiotic X 948"
FAM_000411   PRD_000491   34    BioAustralis "Antibiotic X 53III"
FAM_000411   PRD_000491   35    ChemBank
;2-Quinoxalinecarboxmide, N,N'-[2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa -28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosan e-7,20-diyl]bis-
;
FAM_000411   PRD_000491   36    ChemBank
;N-[3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carboxamide
;
FAM_000411   PRD_000491   37    ChemBank
;N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide)
;
FAM_000411   PRD_000492   38    PDB          QUINOMYCIN
FAM_000411   PRD_000492   39    SciFinder    "SW 163G"
FAM_000411   PRD_000492   40    SciFinder    "Antibiotic UK 63052 (9CI)"
FAM_000411   PRD_000492   41    SciFinder    "UK 63052"
FAM_000411   PRD_000492   42    Beilstein    SW-163G
FAM_000411   PRD_000492   43    PubChem      "UK 63052"
FAM_000411   PRD_000492   44    PubChem      "Antibiotics UK 63052"
FAM_000411   PRD_000492   45    PubChem      Neuro_000276
FAM_000411   PRD_000492   46    PubChem      "Streptomyces antibiotic"
FAM_000411   PRD_000492   47    PubChem      "Streptomyces antibiotic UK-63052"
FAM_000411   PRD_000492   48    PubChem      "NSC 630678"
FAM_000411   PRD_000492   49    PubChem      "AIDS 073381"
FAM_000411   PRD_000492   50    PubChem      NCI60_009979
FAM_000411   PRD_000492   51    ChemSpider   "Antibiotic UK 63052"
FAM_000411   PRD_000492   52    ChemSpider   "Streptomyces antibiotic UK-63052"
FAM_000411   PRD_000492   53    ChemBank     Echinomycin
FAM_000411   PRD_000492   54    ChemBank     "2-Quinoxalinecarboxmide, N,N'-[2,4,12,15,17,25-hexamethyl-11, 24-bis(1-methylethyl) -27-(methylthio)-3,6,10,13,16,19,23, 26-octaoxo-9,22-dioxa -28-thia-2,5,12,15,18, 25-hexaazabicyclo[12.12.3]nonacosan e-7,20-diyl]bis-"
FAM_000411   PRD_000492   55    ChemBank     "Echinomycin A"
FAM_000411   PRD_000492   56    ChemBank     Levomycin
FAM_000411   PRD_000492   57    ChemBank     "Quinomycin A"
FAM_000411   PRD_000492   58    ChemBank     "S-426-S (Lepetit)"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000411   PRD_000488   1     NovelAntibiotics     Function                  Antitumor
FAM_000411   PRD_000488   2     PubChem              Function                  "antibacterial activity"
FAM_000411   PRD_000491   3     NovelAntibiotics     Function                  Antitumor
FAM_000411   PRD_000491   4     PubChem              Function                  "Binds to DNA"
FAM_000411   PRD_000491   5     PubChem              Function                  "inhibitor of RNA synthesis"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000411   PRD_000488   1     1     CAS                    External_Reference_ID     13758-27-5
FAM_000411   PRD_000488   2     1     Merck                  External_Reference_ID     14:9733
FAM_000411   PRD_000488   3     1     Beilstein              External_Reference_ID     604469
FAM_000411   PRD_000488   4     1     NovelAntibiotics       External_Reference_ID     140098
FAM_000411   PRD_000488   5     1     PubChem                External_Reference_ID     316447
FAM_000411   PRD_000488   6     1     ChemSpider             External_Reference_ID     65433
FAM_000411   PRD_000488   7     1     KEGG                   KEGG_Compound_ID          C15721
FAM_000411   PRD_000488   8     1     MESH                   MESH_Unique_ID            C031945
FAM_000411   PRD_000488   9     1     WikiPedia              Image                     http://upload.wikimedia.org/wikipedia/commons/thumb/6/63/Triostin_A.png/800px-Triostin_A.png
FAM_000411   PRD_000488   10    1     Nature                 Image                     http://www.nature.com/nchembio/journal/v2/n8/images/nchembio803-sc1.jpg
FAM_000411   PRD_000491   11    1     CAS                    External_Reference_ID     512-64-1
FAM_000411   PRD_000491   12    1     Merck                  External_Reference_ID     14:3497
FAM_000411   PRD_000491   13    1     Beilstein              External_Reference_ID     1071158
FAM_000411   PRD_000491   14    2     Beilstein              External_Reference_ID     78671
FAM_000411   PRD_000491   15    1     NovelAntibiotics       External_Reference_ID     140094
FAM_000411   PRD_000491   16    1     PubChem                External_Reference_ID     23724556
FAM_000411   PRD_000491   17    1     ChemSpider             External_Reference_ID     3085
FAM_000411   PRD_000491   18    1     KEGG                   KEGG_Compound_ID          C15722
FAM_000411   PRD_000491   19    1     MESH                   MESH_Unique_ID            D004448
FAM_000411   PRD_000491   20    1     Sigma-Aldrich          Vender_ID                 E-4392
FAM_000411   PRD_000491   21    1     "BioAustralis Fine Chemicals" URL                       http://www.bioaustralis.com/pdfs/quinomycina.pdf
FAM_000411   PRD_000491   22    1     Cancer.gov             URL                       http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=39587
FAM_000411   PRD_000491   23    1     Sigma-Aldrich          URL                       http://www.sigmaaldrich.com/catalog/search/ProductDetail/FLUKA/44659
FAM_000411   PRD_000491   24    1     Alexis-Biochemicals    URL                       http://www.alexis-biochemicals.com/Echinomycin.5+M58cde746e0d.0.html
FAM_000411   PRD_000492   25    1     CAS                    External_Reference_ID     120763-23-7
FAM_000411   PRD_000492   26    2     CAS                    External_Reference_ID     120832-02-2
FAM_000411   PRD_000492   27    1     Beilstein              External_Reference_ID     11250492
FAM_000411   PRD_000492   28    1     PubChem                External_Reference_ID     131388
FAM_000411   PRD_000492   29    1     MESH                   MESH_Unique_ID            C059030
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  2005  33    6214   6224  10.1093/nar/gki916           1283521  " Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: insight from thermodynamic integration free energy simulations"  "Nucleic Acids Res."  
 2  1994  22    5484   5491  ?                            7816641  " NMR investigation of Hoogsteen base pairing in quinoxaline antibiotic-DNA complexes: comparison of 2:1 echinomycin, triostin A and [N-MeCys3,N-MeCys7] TANDEM complexes with DNA oligonucleotides"  "Nucleic Acids Research"  
 3  1993  32    2498   2508  10.1021/bi00061a006                ?  " Solution structure of a complex between [N-MeCys3,N-MeCys7]TANDEM and [d(GATATC)]2"  Biochemistry  
 4  1994  18   12397  12404  ?                            7918462  " Sequence specificity of quinoxaline antibiotics. 2. NMR studies of the binding of [N-MeCys3,N-MeCys7]TANDEM and triostin A to DNA containing a CpI step"  Biochemistry  
 5  1994  18   12386  12396  ?                            7918461  " Sequence specificity of quinoxaline antibiotics. 1. Solution structure of a 1:1 complex between triostin A and [d(GACGTC)]2 and comparison with the solution structure of the [N-MeCys3,N-MeCys7]TANDEM-[d(GATATC)]2 complex."  Biochemistry  
 6  1995  236    164    179  ?                            7853395  "Solution structure of a quinomycin bisintercalator-DNA complex"  "J Mol Biol."  
 7  2005  33    5622   5632  10.1093/nar/gki869                 ?  " Characterization of the bisintercalative DNA binding mode of a bifunctional platinum/acridine agent"  "Nucleic Acids Research"  
 8  1993  32    2498   2508  ?                            8448108  " Solution structure of a complex between [N-MeCys3,N-MeCys7]TANDEM and [d(GATATC)]2."  Biochemistry  
 9  1992  31    1407   1415  ?                            1310611  " Proton exchange in DNA-luzopeptin and DNA-echinomycin bisintercalation complexes: rates and processes of base-pair opening"  Biochemistry  
10  1978  17    5071   5078  ?                              31902  " DNA bifunctional intercalators. I. Synthesis and conformational properties of an ethidium homodimer and of an acridine ethidium heterodimer"  Biochemistry  
11  1995  23     753    760  ?                            7708489  " Site selective bis-intercalation of a homodimeric thiazole orange dye in DNA oligonucleotides"  "Nucleic Acids Research"  
12  1996  240    195    208  ?                            8797854  " Sequence-selective intercalation of antitumour bis-naphthalimides into DNA. Evidence for an approach via the major groove."  "Eur J Biochem."  
13  2004  50     201    207  10.1016/j.phrs.2004.01.005         ?  " Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway"  "Pharmacological Research"  
14  2007  71    2969   2976  ?                           18071270  "Relative and Absolute Configuration of Antitumor Agent SW-163D"  "Biosci Biotechnol Biochem."  
15  1994  304    967    979  ?                            7818504  
; Binding of quinomycin antibiotic UK-65,662 to DNA: 'H-n.m.r. studies of drug-induced changes in DNA conformation in complexes with d(ACGT)2
 and d(GACGTC)2
;
  "Biochem. J."  
16  2008  47    7900   7906  10.1021/bi800573p                  ?  "DNA Binding by Analogues of the Bifunctional Intercalator TANDEM"  Biochemistry  
17  2007  24     109    126  ?                           17268609  " Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies"  "Nat Prod Rep."  
18  2005  33    6214   6224  ?                           16282585  " Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: insight from thermodynamic integration free energy simulations."  "Nucleic Acids Res."  
19  2000  19    1337   1353  ?                           11097063  " DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin"  "Nucleosides Nucleotides Nucleic Acids"  
20  1986  6      275    340  ?                            3526052  "Polyfunctional DNA intercalating agents"  "Med Res Rev."  
21  1982  14     805    809  ?                            6182040  "Nilemycin, an intercalating agent for deoxyribonucleic acid"  "Int J Biochem."  
22  1994  7      109    122  ?                            7826671  "DNA recognition by intercalators and hybrid molecules"  "J Mol Recognit."  
23  1999  6        1     27  ?                            9873113  "Pyrroloquinoline and pyridoacridine alkaloids from marine sources"  "Curr Med Chem."  
24  1985  13    2305   2323  ?                            4000957  " A comparison of the structure of echinomycin and triostin A complexed to a DNA fragment"  "Nucleic Acids Res."  
25  1984  225   1115   1121  ?                            6474168  "The molecular structure of a DNA-triostin A complex"  Science  
26  1986  4      319    342  ?                            3271447  " Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex"  "J Biomol Struct Dyn."  
27  1986  232   1255   1258  ?                            3704650  "Non-Watson-Crick G.C and A.T base pairs in a DNA-antibiotic complex."  Science  
28  2006  2      423    428  10.1038/nchembio803            ?  "Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli"  "Nature Chemical Biology"  
29  1984  ?     1601   1605  10.1039/P29840001601               ?  "Crystal and molecular structure of the DNA-binding antitumour antibiotic triostin A"  "J. Chem. Soc., Perkin Trans. 2"  
30  1995  51     987    999  10.1107/S010876819401503X          ?  "Structures of quinoxaline antibiotics"  "Acta Crystallogr.,Sect.B:Struct.Sci."  
31  1982  104   3401   3408  10.1021/ja00376a027                ?  " Crystal and molecular structure of the quinoxaline antibiotic analog TANDEM (des-N-tetramethyltriostin A)"  "J. Am. Chem. Soc."  
32  1981  289    817    819  10.1038/289817a0                   ?  "Structure of TANDEM and its implication for bifunctional intercalation into DNA"  Nature  
33  2005  65    9047   9055  ?                           16204079  "Echinomycin, a Small-Molecule Inhibitor of Hypoxia-Inducible Factor-1 DNA-Binding Activity"  "Cancer Research"  
34  2007  104   9445   9450  10.1073/pnas.0611662104            ?  "Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy"  "Proc. Nat. Acad. Sci."  
35  2005  D61    442    448  10.1107/S090744490500137X          ?  "Structures of complexes between echinomycin and duplex DNA"  "Acta Crystallogr.,Sect.D:Biological Crystallography"  
36  1995  246    164    179  ?                            7853395  "Solution Structure of a Quinomycin Bisintercalator-DNA Complex"  "Journal of Molecular Biology"  
37  1981  ?       46     47  10.1039/C39810000046               ?  "Characterisation of eight antibiotics of the quinomycin group by field desorption mass spectrometry"  "J. Chem. Soc., Chem. Commun."  
38  1990  43     796    808  ?                            2387774  "Quinaldopeptin, a novel antibiotic of the quinomycin family"  "J Antibiot (Tokyo)"  
39  2004  50     201    207  ?                           15177310  "Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway"  "Pharmacol. Res."  
40  1995  51     987    999  10.1107/S010876819401503X          ?  "Structures of quinoxaline antibiotics"  "Acta Crystallogr.,Sect.B:Struct.Sci."  
41  1989  42     206    217  ?                            2925512  " UK-63,052 complex, new quinomycin antibiotics from Streptomyces braegensis subsp. japonicus; taxonomy, fermentation, isolation, characterisation and antimicrobial activity."  "J Antibiot (Tokyo)."  
42  1980  7        9      ?  ?                                  ?  ?  ACA,Ser.2  
43  1980  7       14      ?  ?                                  ?  ?  ACA,Ser.2  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1    1  "Marco, E."  
 1    2  "Negri, A."  
 1    3  "Luque, F.J."  
 1    4  "Gago, F."  
 3    5  "Addess, K.J."  
 3    6  "Feigon, J."  
 4    7  "Addess, K.J."  
 4    8  "Feigon, J."  
 5    9  "Addess, K.J."  
 5   10  "Feigon, J."  
 6   11  "Chen, H."  
 6   12  "Patel, D.J."  
 7   13  "Choudhury, J.R."  
 7   14  "Bierbach, U."  
 8   15  "Addess, K.J."  
 8   16  "Sinsheimer, J.S."  
 8   17  "Feigon, J."  
 9   18  "Leroy, J.L."  
 9   19  "Gao, X.L."  
 9   20  "Misra, V."  
 9   21  "Gueron, M."  
 9   22  "Patel, D.J."  
10   23  "Gaugain, B."  
10   24  "Barbet, J."  
10   25  "Oberlin, R."  
10   26  "Roques, B.P."  
10   27  "Le Pecq, J.B."  
11   28  "Jacobsen, J.P."  
11   29  "Pedersen, J.B."  
11   30  "Hansen, L.F."  
11   31  "Wemmer, D.E."  
12   32  "Bailly, C."  
12   33  "Brana, M."  
12   34  "Waring. M.J."  
13   35  "Park, J.Y."  
13   36  "Park, S.J."  
13   37  "Shim, K.Y."  
13   38  "Lee, K.J."  
13   39  "Kim, Y.-B."  
13   40  "Kim, Y.H."  
13   41  "Kim, S.K."  
14   42  "Nakaya, M."  
14   43  "Oguri, H."  
14   44  "Takahashi, K."  
14   45  "Fukushi, E."  
14   46  "Watanabe, K."  
14   47  "Oikawa, H."  
15   48  "Searle, M.S."  
16   49  "Hampshire, A.J."  
16   50  "Rusling, D.A."  
16   51  "Bryan, S."  
16   52  "Paumier, D."  
16   53  "Dawson, S.J."  
16   54  "Malkinson, J.P."  
16   55  "Searcey , M."  
16   56  "Fox, K.R."  
17   57  "Dawson, S."  
17   58  "Malkinson, J.P."  
17   59  "Paumier, D."  
17   60  "Searcey, M."  
18   61  "Marco, E."  
18   62  "Negri, A."  
18   63  "Luque, F.J."  
18   64  "Gago, F."  
19   65  "Bailly, C."  
19   66  "Crow, S."  
19   67  "Minnock, A."  
19   68  "Waring, M.J."  
20   69  "Wakelin, L.P."  
21   70  "Shimi, I.R."  
21   71  "Abdallah, N.M."  
21   72  "Ali, F.T."  
21   73  "Khater, H.D."  
22   74  "Waring, M.J."  
22   75  "Bailly, C."  
23   76  "Ding, Q."  
23   77  "Chichak, K."  
23   78  "Lown, J.W."  
24   79  "Ughetto, G."  
24   80  "Wang, A.H."  
24   81  "Quigley, G.J."  
24   82  "van der Marel, G.A."  
24   83  "van Boom, J.H."  
24   84  "Rich, A."  
25   85  "Wang, A.H."  
25   86  "Ughetto, G."  
25   87  "Quigley, G.J."  
25   88  "Hakoshima, T."  
25   89  "van der Marel, G.A."  
25   90  "van Boom, J.H."  
25   91  "Rich, A."  
26   92  "Wang, A.H."  
26   93  "Ughetto, G."  
26   94  "Quigley, G.J."  
26   95  "Rich, A."  
27   96  "Quigley, G.J."  
27   97  "Ughetto, G."  
27   98  "van der Marel, G.A."  
27   99  "van Boom J.H."  
27  100  "Wang, A.H."  
27  101  "Rich, A."  
28  102  "Watanabe, K."  
28  103  "Hotta, K."  
28  104  "Praseuth, A.P."  
28  105  "Koketsu, K."  
28  106  "Migita, A."  
28  107  "Boddy, C.N."  
28  108  "Wang, C.C.C."  
28  109  "Oguri, H."  
28  110  "Oikawa, H."  
29  111  "Sheldrick, G.M."  
29  112  "Guy, J.J."  
29  113  "Kennard, O."  
29  114  "Rivera, V."  
29  115  "Waring, M.J."  
30  116  "Sheldrick, G.M."  
30  117  "Heine, A."  
30  118  "Schmidt-Base, K."  
30  119  "Pohl, E."  
30  120  "Jones, P.G."  
30  121  "Paulus, E."  
30  122  "Waring, M.J."  
31  123  "Hossain, M.B."  
31  124  "van der Helm, D."  
31  125  "Olsen, R.K."  
31  126  "Jones, P.G."  
31  127  "Sheldrick, G.M."  
31  128  "Egert, E."  
31  129  "Kennard, O."  
31  130  "Waring, M.J."  
31  131  "Viswamitra, M.A."  
32  132  "Viswamitra, M.A."  
32  133  "Kennard, O."  
32  134  "Cruse, W.B.T."  
32  135  "Egert, E."  
32  136  "Sheldrick, G.M."  
32  137  "Jones, P.G."  
32  138  "Waring, M.J."  
32  139  "Wakelin, L.P.G."  
32  140  "Olsen, R.K."  
33  141  "Kong, D."  
33  142  "Park, E.J."  
33  143  "Stephen, A.G."  
33  144  "Calvani, M."  
33  145  "Cardellina, J.H."  
33  146  "Monks, A."  
33  147  "Fisher, R.J."  
33  148  "Shoemaker, R.H."  
33  149  "Melillo, G."  
34  150  "Cairns, R.A."  
35  151  "Cuesta-Seijo, J.A."  
35  152  "Sheldrick, G.M."  
36  153  "Chen, H."  
36  154  "Patel, D.J."  
37  155  "Bojesen, G."  
37  156  "Gauvreau, D."  
37  157  "Williams, D.H."  
37  158  "Waring, M.J."  
38  159  "Toda, S."  
38  160  "Sugawara, K."  
38  161  "Nishiyama, Y."  
38  162  "Ohbayashi, M."  
38  163  "Ohkusa, N."  
38  164  "Yamamoto, H."  
38  165  "Konishi, M."  
38  166  "Oki, T."  
39  167  "Park, J.Y."  
39  168  "Park, S.J."  
39  169  "Shim, K.Y."  
39  170  "Lee, K.J."  
39  171  "Kim, Y.B."  
39  172  "Kim, Y.H."  
39  173  "Kim, S.K."  
40  174  "Sheldrick, G.M."  
40  175  "Heine, A."  
40  176  "Schmidt-Base, K."  
40  177  "Pohl, E."  
40  178  "Jones, P.G."  
40  179  "Paulus, E."  
40  180  "Waring, M.J."  
41  181  "Rance, M.J."  
41  182  "Ruddock, J.C."  
41  183  "Pacey, M.S."  
41  184  "Cullen, W.P."  
41  185  "Huang, L.H."  
41  186  "Jefferson, M.T."  
41  187  "Whipple, E.B."  
41  188  "Maeda, H."  
41  189  "Tone, J."  
42  190  "Kennard, O."  
42  191  "Cruse, W.B.T."  
42  192  "Viswamitra, M.A."  
42  193  "Sheldrick, G.M."  
42  194  "Jones, P.G."  
43  195  "Hossain, M.B."  
43  196  "van der Helm, D."  
43  197  "Olsen, R.K."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000411	2012-02-08	RCSB	"Create family"	
FAM_000411	2013-10-16	RCSB	"Initial release"	
#
