data_FAM_000060
#
_pdbx_reference_molecule_family.family_prd_id   FAM_000060
_pdbx_reference_molecule_family.name            Cyclosporin
_pdbx_reference_molecule_family.release_status  REL
_pdbx_reference_molecule_family.replaces        ?
_pdbx_reference_molecule_family.replaced_by     ?
#
loop_
_pdbx_reference_molecule_list.family_prd_id
_pdbx_reference_molecule_list.prd_id
FAM_000060   PRD_000142  
FAM_000060   PRD_000143  
FAM_000060   PRD_000144  
FAM_000060   PRD_000764  
FAM_000060   PRD_000765  
FAM_000060   PRD_000766  
FAM_000060   PRD_000767  
FAM_000060   PRD_000768  
FAM_000060   PRD_001108  
FAM_000060   PRD_001122  
FAM_000060   PRD_001123  
FAM_000060   PRD_001132  
#
loop_
_pdbx_reference_molecule_related_structures.family_prd_id
_pdbx_reference_molecule_related_structures.ordinal
_pdbx_reference_molecule_related_structures.citation_id
_pdbx_reference_molecule_related_structures.db_name
_pdbx_reference_molecule_related_structures.db_accession
_pdbx_reference_molecule_related_structures.db_code
_pdbx_reference_molecule_related_structures.name
_pdbx_reference_molecule_related_structures.formula
FAM_000060   1   8  CCDC  ?  ICYSPA    "Iodo-cyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                       "C62 H110 I1 N11 O12"  
FAM_000060   2   9  CCDC  ?  DEKSAN    "Cyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                            "C62 H111 N11 O12"  
FAM_000060   3  10  CCDC  ?  KEPNAU    "Cyclosporin A monohydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                "C62 H111 N11 O12, H2 O"  
FAM_000060   4  11  CCDC  ?  JOKMAX    " (-4-PSI-5-,CS-NH,-7-PSI-8-,CS-NH)-Cyclosporin A diethyl ether solvate, seqres C11 ALA*-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                  "C62 H111 N11 O10 S2, C4 H10 O"  
FAM_000060   5  12  CCDC  ?  LIKNIC    " methyl((4S)-METHYL)NORLEU-4 Cyclosporin cyclophilin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                   "C63 H113 N11 O12"  
FAM_000060   6  13  CCDC  ?  ZADRIF    " cyclo-(alanyl-d-alanyl-n-methylleucyl-n-methylleucyl-N-methylvalyl-alpha-(1-oxo-2-methylhex-4-enyl)sarcosyl-valyl-sarcosyl-N-methylleucyl-valyl-N-methylleucyl), seqres C11 ALA-ALA-LEU*-LEU*-VAL*-SAR*-VAL*-SAR-LEU*-VAL-LEU*-"                                         "C63 H111 N11 O12"  
FAM_000060   7  14  CCDC  ?  ZAJDUJ    "sulfhydryl cyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                 "C64 H113 N11 O12 S1"  
FAM_000060   8  15  CCDC  ?  NAMPIA    "isocyclosporin A acetone solvate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*,GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                         "C62 H111 N11 O12, 2(C3 H6 O)"  
FAM_000060   9  16  CCDC  ?  TECRIC    "cyclosporin A dimethylisosorbide solvate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                 "C62 H111 N11 O12, C8 H14 O4"  
FAM_000060  10  17  CCDC  ?  SUQNUN    "cyclosporin E acetone solveate monohydrate clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                     "C61 H109 N11 O12, C3 H6 O, H2 O"  
FAM_000060  11  18  CCDC  ?  CUQRUB    " O-acetyl-(4R)-4-(E-2-butenyl)-4,N-dimethyl-L-threonylcyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                      "C64 H113 N11 O13"  
FAM_000060  12  18  CCDC  ?  CUQSAI    " O-acetyl-(4R)-4-(4-bromobutyl)-4,N-dimethyl-L-threonylcyclosporin A, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                     "C64 H112 BR1 N11 O13"  
FAM_000060  13  19  CCDC  ?  DUDQAU    "cyclosporin H diethyl ether solvate monohydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                          "C62 H111 N11 O12, 0.5(C4 H10 O), H2 O"  
FAM_000060  14  20  CCDC  ?  HUCVIK    "cyclosporin V t-butyl methyl ether clathrate, seqres C11 GLY*-ALA-LEU*-LEU*-VAL*-THR*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                            "C63 H113 N11 O12, 2(C5 H12 O)"  
FAM_000060  15  20  CCDC  ?  HUCVOQ    "dihydrocyclosporin A t-butyl methyl ether clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                      "C62 H113 N11 O12, 2(C5 H12 O)"  
FAM_000060  16  21  CCDC  ?  LOWGOT    "cyclosporin A tetrahydrofuran clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                  "C62 H111 N11 O12, C4 H8 O"  
FAM_000060  17  21  CCDC  ?  LOWHAG    "cyclosporin A di-n-butyl ether clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                 "C62 H111 N11 O12, C8 H18 O"  
FAM_000060  18  21  CCDC  ?  LOWHAG01  "cyclosporin A di-n-butyl ether clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                 "C62 H111 N11 O12, C8 H18 O"  
FAM_000060  19  22  CCDC  ?  GABWOW    "cyclosporin G methanol solvate hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-NVA-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                    "C63 H113 N11 O12, 0.5(C H4 O), 2.4(H2 O)"  
FAM_000060  20  22  CCDC  ?  GABWUC    "cyclosporin G methanol solvate hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-NVA-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                    "C63 H113 N11 O12, C H4 O, 2.4(H2 O)"  
FAM_000060  21  22  CCDC  ?  GABXAJ    "cyclosporin H hexahydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                "C62 H111 N11 O12, 6(H2 O)"  
FAM_000060  22  22  CCDC  ?  GABXEN    "cyclosporin H hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                    "C62 H111 N11 O12, 6.4(H2 O)"  
FAM_000060  23  23  CCDC  ?  KADFOL    "cyclosporin A acetone monohydrate clathrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-SAR*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                              "C62 H111 N11 O12, 3(C3 H6 O), H2 O"  
FAM_000060  24  13  CCDC  ?  ZADREB    " cyclo-(alanyl-D-alanyl-N-methylleucyl-N-methylleucyl-N-methylvalyl-alpha-(1-oxo-2-methylhex-4-enyl)sarcosyl-valyl-sarcosyl-N-methylleucyl-valyl-N-methylleucyl) di-isopropyl ether solvate hemihydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-SAR*-VAL*-SAR-LEU*-VAL-LEU*-"  "C63 H111 N11 O12"  
FAM_000060  25  24  CCDC  ?  KEPNAU01  "Cyclosporin A monohydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                "C62 H111 N11 O12, H2 O"  
FAM_000060  26  25  CCDC  ?  LOSLEL    "Cyclosporin A hydrate, seqres C11 ALA-ALA-LEU*-LEU*-VAL*-GLY*-GLY*-SAR-LEU*-VAL-LEU*-"                                                                                                                                                                                    "C62 H111 N11 O12, 0.75(H2 O)"  
#
loop_
_pdbx_reference_molecule_synonyms.family_prd_id
_pdbx_reference_molecule_synonyms.prd_id
_pdbx_reference_molecule_synonyms.ordinal
_pdbx_reference_molecule_synonyms.source
_pdbx_reference_molecule_synonyms.name
FAM_000060   PRD_000142   1     PDB          CYCLOSPORIN
FAM_000060   PRD_000142   2     SciFinder    Cyclosporine
FAM_000060   PRD_000142   3     SciFinder    "Cyclosporine A"
FAM_000060   PRD_000142   4     SciFinder    Debio088
FAM_000060   PRD_000142   5     SciFinder    Equoral
FAM_000060   PRD_000142   6     SciFinder    Gengraf
FAM_000060   PRD_000142   7     SciFinder    Imusporin
FAM_000060   PRD_000142   8     SciFinder    "NSC 290193"
FAM_000060   PRD_000142   9     SciFinder    Neoplanta
FAM_000060   PRD_000142   10    SciFinder    Neoral
FAM_000060   PRD_000142   11    SciFinder    "OL 27-400"
FAM_000060   PRD_000142   12    SciFinder    "Papilock Mini"
FAM_000060   PRD_000142   13    SciFinder    "Ramihyphin A"
FAM_000060   PRD_000142   14    SciFinder    Restasis
FAM_000060   PRD_000142   15    SciFinder    S-Neoral
FAM_000060   PRD_000142   16    SciFinder    "SDZ-OXL 400"
FAM_000060   PRD_000142   17    SciFinder    Sandimmun
FAM_000060   PRD_000142   18    SciFinder    "Sandimmun Neoral"
FAM_000060   PRD_000142   19    SciFinder    Sandimmune
FAM_000060   PRD_000142   20    SciFinder    "Sandimmune Neoral"
FAM_000060   PRD_000142   21    SciFinder    Sang-35
FAM_000060   PRD_000142   22    SciFinder    SangCyA
FAM_000060   PRD_000142   23    SciFinder    "Sigmasporin Microoral"
FAM_000060   PRD_000142   24    SciFinder    "Zinograf ME"
FAM_000060   PRD_000142   25    SciFinder    Abrammune
FAM_000060   PRD_000142   26    SciFinder    "Antibiotic S 7481F1"
FAM_000060   PRD_000142   27    SciFinder    "Arpimune ME"
FAM_000060   PRD_000142   28    SciFinder    Cicloral
FAM_000060   PRD_000142   29    SciFinder    "Cicloral (antibiotic)"
FAM_000060   PRD_000142   30    SciFinder    Ciclosporin
FAM_000060   PRD_000142   31    SciFinder    "Ciclosporina Germed"
FAM_000060   PRD_000142   32    SciFinder    "Cipol N"
FAM_000060   PRD_000142   33    SciFinder    Consupren
FAM_000060   PRD_000142   34    Merck        cyclosporine
FAM_000060   PRD_000142   35    Merck        ciclosporin
FAM_000060   PRD_000142   36    Merck        Atopica
FAM_000060   PRD_000142   37    Merck        Sandimmune
FAM_000060   PRD_000142   38    Merck        Neoral
FAM_000060   PRD_000142   39    Merck        Optimmune
FAM_000060   PRD_000142   40    Merck        Restasis
FAM_000060   PRD_000142   41    KEGG         Ciclosporin
FAM_000060   PRD_000142   42    KEGG         Cyclosporine
FAM_000060   PRD_000142   43    KEGG         "Cyclosporin A"
FAM_000060   PRD_000142   44    KEGG         Gengraf
FAM_000060   PRD_000142   45    KEGG         Neoral
FAM_000060   PRD_000142   46    KEGG         Restasis
FAM_000060   PRD_000142   47    KEGG         Sandimmune
FAM_000060   PRD_000142   48    DrugBank     Ciclosporin
FAM_000060   PRD_000142   49    DrugBank     "Cyclosporin A"
FAM_000060   PRD_000142   50    DrugBank     Cyclosporin
FAM_000060   PRD_000142   51    DrugBank     Gengraf
FAM_000060   PRD_000142   52    DrugBank     Neoral
FAM_000060   PRD_000142   53    DrugBank     Restasis
FAM_000060   PRD_000142   54    DrugBank     Sandimmune
FAM_000060   PRD_000142   55    DrugBank     Sangcya
FAM_000060   PRD_000142   56    Norine       cyclosporine
FAM_000060   PRD_000142   57    Norine       ciclosporin
FAM_000060   PRD_000142   58    Norine       ciclosporine
FAM_000060   PRD_000142   59    PubChem      "cyclosporin A"
FAM_000060   PRD_000142   60    PubChem      cyclosporine
FAM_000060   PRD_000142   61    PubChem      Ciclosporin
FAM_000060   PRD_000142   62    PubChem      Cyclosporin
FAM_000060   PRD_000142   63    PubChem      Sandimmune
FAM_000060   PRD_000142   64    PubChem      "Cyclosporine A"
FAM_000060   PRD_000142   65    PubChem      "Ramihyphin A"
FAM_000060   PRD_000142   66    PubChem      Sigmasporin
FAM_000060   PRD_000142   67    PubChem      Consupren
FAM_000060   PRD_000142   68    PubChem      Cyclokat
FAM_000060   PRD_000142   69    ChemSpider   "Cipol N"
FAM_000060   PRD_000142   70    ChemSpider   Cyclosporine
FAM_000060   PRD_000142   71    ChemSpider   Optimmune
FAM_000060   PRD_000142   72    ChemSpider   "Ramihyphin A"
FAM_000060   PRD_000142   73    ChemSpider   S-Neoral
FAM_000060   PRD_000142   74    ChemSpider   "S 7481F1"
FAM_000060   PRD_000142   75    ChemSpider   "Antibiotic S 7481F1"
FAM_000060   PRD_000142   76    ChemSpider   Consupren
FAM_000060   PRD_000142   77    ChemSpider   "Consupren S"
FAM_000060   PRD_000142   78    ChemSpider   Equoral
FAM_000060   PRD_000142   79    ChemSpider   Gengraf
FAM_000060   PRD_000142   80    ChemSpider   Modusik-A
FAM_000060   PRD_000142   81    ChemSpider   Neoplanta
FAM_000060   PRD_000142   82    ChemSpider   Papilock
FAM_000060   PRD_000142   83    ChemSpider   Pulminiq
FAM_000060   PRD_000142   84    ChemSpider   Sandimmune
FAM_000060   PRD_000142   85    ChemSpider   Neoral
FAM_000060   PRD_000142   86    ChemBank     Ciclosporin
FAM_000060   PRD_000142   87    ChemBank     "Cipol N"
FAM_000060   PRD_000142   88    ChemBank     "Cyclosporin A"
FAM_000060   PRD_000142   89    ChemBank     Cyclosporine
FAM_000060   PRD_000142   90    ChemBank     "Cyclosporine A"
FAM_000060   PRD_000142   91    ChemBank     Neoplanta
FAM_000060   PRD_000142   92    ChemBank     "Ramihyphin A"
FAM_000060   PRD_000142   93    ChemBank     "Sang 35"
FAM_000060   PRD_000142   94    ChemBank     Apo-Cyclosporine
FAM_000060   PRD_000142   95    ChemBank     Atopica
FAM_000060   PRD_000142   96    ChemBank     Consupren
FAM_000060   PRD_000142   97    ChemBank     Gengraf
FAM_000060   PRD_000142   98    ChemBank     Neoral
FAM_000060   PRD_000142   99    ChemBank     Optimmune
FAM_000060   PRD_000142   100   ChemBank     Pulminiq
FAM_000060   PRD_000142   101   ChemBank     Restasis
FAM_000060   PRD_000142   102   ChemBank     Rhoxal-cyclosporine
FAM_000060   PRD_000142   103   ChemBank     Sandimmun
FAM_000060   PRD_000142   104   ChemBank     "Sandimmun Neoral"
FAM_000060   PRD_000142   105   ChemBank     Sandimmune
FAM_000060   PRD_000142   106   ChemBank     "Sandimmune I.V."
FAM_000060   PRD_000142   107   ChemBank     Sandoz-cyclosporine
FAM_000060   PRD_000142   108   ChemBank     SangCya
FAM_000060   PRD_000142   109   ChemSpider
;(E)-14,17,26,32-tetrabutyl-5-ethyl-8-(1-hydroxy-2-methylhex-4-enyl)-1,3,9,12,15,18,20,23,27-nonamethyl-11,29-dipropyl-1,3,6,9,12,15,18,21,24,27,30- undecaazacyclodotriacontan-2,4,7,10,13,16,19,22,25,28,31-undecaone
;
FAM_000060   PRD_000143   110   Merck        Val2-Cyclosporine
FAM_000060   PRD_000143   111   www.enzolifesciences.com "Val2-cyclosporin, 7-L-Valine-cyclosporin A"
FAM_000060   PRD_000144   112   www.rspharmchem.com "Cyclosporin C, Thr2-cyclosporine"
FAM_000060   PRD_000144   113   www.enzolifesciences.com "Thr2-cyclosporin A, 7-L-Threonine-cyclosporin A"
FAM_000060   PRD_000143   114   PDB          "2-VAL 3-S-METHYL-SARCOSINE CYCLOSPORIN"
FAM_000060   PRD_000764   115   PDB          "1-(6,7-DIHYDRO)MEBMT 2-VAL 3-D-(2-S-METHYL)SARCOSINE CYCLOSPORIN"
FAM_000060   PRD_000765   116   PDB          "N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A"
FAM_000060   PRD_000766   117   PDB          (5-hydroxynorvaline)-2-cyclosporin
FAM_000060   PRD_000767   118   PDB          "3-D-SER CYCLOSPORIN"
FAM_000060   PRD_000768   119   PDB          "4 MEILE CYCLOSPORIN"
FAM_000060   PRD_001108   120   PDB          "4, N-DIMETHYLNORLEUCINE Cyclosporin A"
FAM_000060   PRD_001122   121   PDB          "2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN"
FAM_000060   PRD_001123   122   PDB          "THR2, LEU5, D-HIV8, LEU10 CYCLOSPORIN"
FAM_000060   PRD_001132   123   PDB          "2-VAL CYCLOSPORIN"
#
loop_
_pdbx_reference_molecule_annotation.family_prd_id
_pdbx_reference_molecule_annotation.prd_id
_pdbx_reference_molecule_annotation.ordinal
_pdbx_reference_molecule_annotation.source
_pdbx_reference_molecule_annotation.type
_pdbx_reference_molecule_annotation.text
FAM_000060   PRD_000142   1     KEGG                 Function                  immunosuppressant
FAM_000060   PRD_000142   2     DrugBank             Function                  immunosuppressant
FAM_000060   PRD_000142   3     DrugBank             Function                  "binds to cyclophilin and forms a complex to inhibit calcineurin, which is normally responsible for activating transcription of interleukin 2"
FAM_000060   PRD_000142   4     DrugBank             Function                  "inhibitor of T-lymphocytes in the G0 or G1 phase of cell cycle"
FAM_000060   PRD_000142   5     DrugBank             Function                  "inhibitor of lymphokine production and Interleukin release"
FAM_000060   PRD_000142   6     DrugBank             Function                  "used in organ and tissue transplants for prophylactic treatment"
FAM_000060   PRD_000142   7     Norine               Function                  "Immunomodulating, antibiotic"
FAM_000060   PRD_000142   8     Norine               Function                  "used to prevent rejections in organ and bone marrow transplants"
FAM_000060   PRD_000142   9     www.enzolifesciences.com "Mechanism of action"     "Binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase - it inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient."
FAM_000060   PRD_000142   10    www.enzolifesciences.com Application               "Important diagnostic tool for the characterization of permeability transition-related phenomena."
FAM_000060   PRD_000142   11    www.enzolifesciences.com "mechanism of action"     "Weak immunosuppressor. Potent inhibitor of tumor promoting phorbol ester TPA/PMA (Prod. No. BML-PE160) in vivo. Potent inhibitor of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro."
FAM_000060   PRD_000144   12    www.rspharmchem.com  Function                  "Nonpolar cyclic oligopeptide with immunosuppressant activity, a Cyclosporin A derivative"
FAM_000060   PRD_000144   13    www.enzolifesciences.com Function                  "Potent immunosuppressor"
FAM_000060   PRD_000142   14    ChemBank             Function                  "immunosuppressive agent"
FAM_000060   PRD_000142   15    ChemBank             Function                  anti-fungal
FAM_000060   PRD_000143   16    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_000764   17    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_000142   18    PMID:8075981         Function                  "immunosuppressive drug, binds cyclosporin A (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A), EC: 5.2.1.8"
FAM_000060   PRD_000765   19    PMID:8075981         Function                  "immunosuppressive drug, binds cyclosporin A (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A), EC: 5.2.1.8"
FAM_000060   PRD_000766   20    PMID:7650689         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_000767   21    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_000768   22    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_001108   23    PMID:7966126         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_001122   24    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_001123   25    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
FAM_000060   PRD_001132   26    PMID:9769216         Function                  "Inhibitor of PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, EC: 5.2.1.8"
#
loop_
_pdbx_reference_molecule_features.family_prd_id
_pdbx_reference_molecule_features.prd_id
_pdbx_reference_molecule_features.ordinal
_pdbx_reference_molecule_features.source_ordinal
_pdbx_reference_molecule_features.source
_pdbx_reference_molecule_features.type
_pdbx_reference_molecule_features.value
FAM_000060   PRD_000142   1     1     CAS                    External_Reference_ID     59865-13-3
FAM_000060   PRD_000142   2     1     Merck                  External_Reference_ID     14:2752
FAM_000060   PRD_000142   3     1     Beilstein              External_Reference_ID     3647785
FAM_000060   PRD_000142   4     1     DrugBank               External_Reference_ID     DB00091
FAM_000060   PRD_000142   5     1     Norine                 External_Reference_ID     NOR00033
FAM_000060   PRD_000142   6     1     PubChem                External_Reference_ID     5284373
FAM_000060   PRD_000142   7     1     ChemSpider             External_Reference_ID     4447449
FAM_000060   PRD_000142   8     1     ChEBI                  External_Reference_ID     4031
FAM_000060   PRD_000142   9     1     ChemDB                 External_Reference_ID     9491791
FAM_000060   PRD_000142   10    1     ChemBank               External_Reference_ID     460
FAM_000060   PRD_000142   11    1     KEGG                   KEGG_Compound_ID          C05086
FAM_000060   PRD_000142   12    1     KEGG                   KEGG_Drug_ID              D00184
FAM_000060   PRD_000142   13    1     MESH                   MESH_Unique_ID            D016572
FAM_000060   PRD_000142   14    1     ATC                    External_Reference_ID     L04AD01
FAM_000060   PRD_000142   15    1     world-of-fungi.org     URL                       http://www.world-of-fungi.org/Mostly_Medical/Harriet_Upton/Harriet_Upton.htm
FAM_000060   PRD_000142   16    1     KEGG                   BRITE_Hierarchy           br08301
FAM_000060   PRD_000142   17    2     KEGG                   BRITE_Hierarchy           br08302
FAM_000060   PRD_000142   18    3     KEGG                   BRITE_Hierarchy           br08303
FAM_000060   PRD_000142   19    1     KEGG                   Therapeutic_Category      1319
FAM_000060   PRD_000142   20    2     KEGG                   Therapeutic_Category      3999
FAM_000060   PRD_000142   21    1     ChEBI                  FunctionalOntology        24613
FAM_000060   PRD_000142   22    2     ChEBI                  StructuralOntology        35718
FAM_000060   PRD_000142   23    3     ChEBI                  StructuralOntology        35705
FAM_000060   PRD_000142   24    4     ChEBI                  StructuralOntology        35842
FAM_000060   PRD_000142   25    5     ChEBI                  StructuralOntology        50177
FAM_000060   PRD_000142   26    1     NADB                   URL                       http://www.nih.go.jp/~jun/NADB/show.cgi/490276.html
FAM_000060   PRD_000142   27    2     NADB                   URL                       http://www.nih.go.jp/~jun/NADB/show.cgi/420231.html
FAM_000060   PRD_000142   28    3     NADB                   URL                       http://www.nih.go.jp/~jun/NADB/show.cgi/420107.html
FAM_000060   PRD_000142   29    4     NADB                   URL                       http://www.nih.go.jp/~jun/NADB/show.cgi/450030.html
FAM_000060   PRD_000142   30    1     wikipedia              Image                     http://upload.wikimedia.org/wikipedia/commons/thumb/9/92/Ciclosporin.svg/620px-Ciclosporin.svg.png
FAM_000060   PRD_000142   31    1     wikipedia              URL                       http://en.wikipedia.org/wiki/Cyclosporine
FAM_000060   PRD_000142   32    1     RXLIST                 URL                       http://www.rxlist.com/sandimmune-drug.htm
FAM_000060   PRD_000142   33    1     Drugs.Com              URL                       http://www.drugs.com/cons/Cyclosporine.html
FAM_000060   PRD_000142   34    1     CAS                    External_Reference_ID     114865-22-4
FAM_000060   PRD_000142   35    1     Beilstein              External_Reference_ID     3586354
FAM_000060   PRD_000142   36    1     PubChem                External_Reference_ID     6436251
FAM_000060   PRD_000143   37    1     CAS                    External_Reference_ID     63775-96-2
FAM_000060   PRD_000143   38    1     Merck                  External_Reference_ID     14:2752
FAM_000060   PRD_000143   39    1     Norine                 External_Reference_ID     NOR00036
FAM_000060   PRD_000144   40    1     CAS                    External_Reference_ID     59787-61-0
FAM_000060   PRD_000144   41    1     Merck                  External_Reference_ID     14:2752
FAM_000060   PRD_000144   42    1     Norine                 External_Reference_ID     NOR00035
#
loop_
_citation.id
_citation.year
_citation.journal_volume
_citation.page_first
_citation.page_last
_citation.pdbx_database_id_DOI
_citation.pdbx_database_id_PubMed
_citation.title
_citation.journal_abbrev
 1  1994  330  1841  1845  ?                                   8196726  "Cyclosporine in severe ulcerative colitis refractory to steroid therapy"                                                                                                                           "N Engl J Med."  
 2  2002  114   433   437  ?                                  12422576  "History of the discovery of cyclosporin and of its early pharmacological development"                                                                                                              "Wien. Klin. Wochenschr"  
 3  2005   10   688   691  10.1016/S1359-6446(05)03395-7  15896681  "Sourcing a chemical succession for cyclosporin from parasites and human pathogens"                                                                                                                 "Drug Discov. Today"  
 4  1981  305   266   269  ?                                   7017414  "Liver transplantation with use of cyclosporin a and prednisone"                                                                                                                                    "N. Engl. J. Med."  
 5  1994  330  1841  1845  ?                                   8196726  "Cyclosporine in severe ulcerative colitis refractory to steroid therapy"                                                                                                                           "N. Engl. J. Med."  
 6  2000  161   631   637  10.1006/exnr.1999.7282         10686082  " Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury"                                                                       "Exp. Neurol."  
 7  2001  176   285   293  10.1007/s002030100324                     ?  " Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum"                                                                       "Arch. Microbiol."  
 8  1976   59  1480  1488  10.1002/hlca.19760590509                  ?  " Crystal and Molecular Structure of an Iodo-derivative of the Cyclic Undecapeptide Cyclosporin A"                                                                                                  Helv.Chim.Acta  
 9  1985   68   682   704  10.1002/hlca.19850680319                  ?  " Peptide conformations. Part 31. The conformation of cyclosporin a in the crystal and in solution"                                                                                                 Helv.Chim.Acta  
10  1990   46  1528  1533  10.1107/S0108270189011480                 ?  "Neutron structure of the immunosuppressant cyclosporin A"                                                                                                                                          "Acta Crystallogr.,Sect.C:Cryst.Struct.Commun."  
11  1991   74  1953  1990  10.1002/hlca.19910740833                  ?  " Thiocyclosporins: Preparation, Solution and Crystal Structure, and Immunosuppressive Activity"                                                                                                    Helv.Chim.Acta  
12  1994   37  3674  3676  10.1021/jm00048a002                       ?  " Improved Binding Affinity for Cyclophilin A by a Cyclosporin Derivative Singly Modified at Its Effector Domain"                                                                                   J.Med.Chem.  
13  1995   78   355   366  10.1002/hlca.19950780208                  ?  " Crystal Structures of Two Modifications of [3,O-didehydro-mebmt1,val2]-cyclosporin and comparison of three different X-ray data sets"                                                             Helv.Chim.Acta  
14  1995   60  2610  2612  10.1021/jo00113a046                       ?  "Preparation of Sulfhydryl Cyclosporin A"                                                                                                                                                           J.Org.Chem.  
15  1996   79  1635  1642  10.1002/hlca.19960790614                  ?  "Crystal Structure and Packing of Isocyclosporin A"                                                                                                                                                 Helv.Chim.Acta  
16  1996  211   313     ?  ?                                         ?  ?                                                                                                                                                                                                   Z.Kristallogr.  
17  1998   63   115   120  10.1135/cccc19980115                      ?  "Conformation, Cyclosporin E, Crystal structure determination, Clathrate"                                                                                                                           Collect.Czech.Chem.Commun.  
18  1999   64    89    98  10.1135/cccc19990089                      ?  " Crystal Structures of Cyclosporin Derivatives: O-Acetyl-(4R)-4-(E-2-butyl)-4,N-dimethyl-L-threonyl-cyclosporin A and O-Acetyl-(4R)-4-[E-2-(4-bromobutyl)]-4,N-dimethyl-L-threonyl-cyclosporin A"  Collect.Czech.Chem.Commun.  
19  2000   65  1317  1328  10.1135/cccc20001317                      ?  "Synthesis and Crystal Structure Determination of Cyclosporin H"                                                                                                                                    Collect.Czech.Chem.Commun.  
20  2000   65  1950  1958  10.1135/cccc20001950                      ?  "Crystal Structures of Two New Cyclosporin Clathrates"                                                                                                                                              Collect.Czech.Chem.Commun.  
21  2000   37   137   153  10.1023/A:1008115029334                   ?  "Cyclosporins of Symmetry P21 - a Series of Clathrates"                                                                                                                                             "J.Inclusion Phenom.Macrocyclic Chem."  
22  2003    1  1466  1474  10.1039/b210086j                          ?  " Two new cyclosporin folds observed in the structures of the immunosuppressant cyclosporin G and the formyl peptide receptor antagonist cyclosporin H at ultra-high resolution"                    Org.Biomol.Chem.  
23  2003    3   441   622  10.1021/cg0300127                         ?  ' How Many "New" Entities Can Be Created from One Active Substance? The Case of Cyclosporin A'                                                                                                      "Cryst.Growth Des."  
24  2010   12  2034     ?  ?                                         ?  ?                                                                                                                                                                                                   CrystEngComm  
25  2009   65   284     ?  ?                                         ?  ?                                                                                                                                                                                                   "Acta Crystallogr. Sect D: Biol Crystallogr."  
#
loop_
_citation_author.citation_id
_citation_author.ordinal
_citation_author.name
 1    1  "Lichtiger, S."  
 1    2  "Present, D.H."  
 1    3  "Kornbluth, A."  
 1    4  "Gelernt, I."  
 1    5  "Bauer, J."  
 1    6  "Galler, G."  
 1    7  "Michelassi, F."  
 1    8  "Hanauer, S."  
 2    9  "Borel, J.F."  
 3   10  "Pritchard, D.I."  
 4   11  "Starzl, T.E."  
 4   12  "Klintmalm, G.B."  
 4   13  "Porter, K.A."  
 4   14  "Iwatsuki, S."  
 4   15  "Schroter, G.P."  
 5   16  "Lichtiger, S."  
 5   17  "Present, D.H."  
 5   18  "Kornbluth, A."  
 5   19  "Gelernt, I."  
 5   20  "Bauer, J."  
 5   21  "Galler, G."  
 5   22  "Michelassi, F."  
 5   23  "Hanauer, S."  
 6   24  "Sullivan, P.G."  
 6   25  "Thompson, M."  
 6   26  "Scheff, S.W."  
 7   27  "Hoppert, M."  
 7   28  "Gentzsch, C."  
 7   29  "Schorgendorfer, K."  
 8   30  "Petcher, T.J."  
 8   31  "Weber, H.-P."  
 8   32  "Ruegger, A."  
 9   33  "Loosli, H.-R."  
 9   34  "Kessler, H."  
 9   35  "Oschkinat, H."  
 9   36  "Weber, H.-P."  
 9   37  "Petcher, T.J."  
 9   38  "Widmer, A."  
10   39  "Knott, R.B."  
10   40  "Schefer, J."  
10   41  "Schoenborn, B.P."  
11   42  "Seebach, D."  
11   43  "Ko, S.Y."  
11   44  "Kessler, H."  
11   45  "Kock, M."  
11   46  "Reggelin, M."  
11   47  "Schmieder, P."  
11   48  "Walkinshaw, M.D."  
11   49  "Bolsterli, J.J."  
12   50  "Papageorgiou, C."  
12   51  "Florineth, A."  
12   52  "Mikol, V."  
13   53  "Pohl, E."  
13   54  "Herbst-Irmer, R."  
13   55  "Sheldrick, G.M."  
13   56  "Dauter, Z."  
13   57  "Wilson, K.S."  
13   58  "Bosterli, J.J."  
13   59  "Bollinger, P."  
13   60  "Kallen, J."  
13   61  "Walkinshaw, M.D."  
14   62  "Eberle, M.K."  
14   63  "Nuninger, F."  
14   64  "Weber, H.-P."  
15   65  "Pohl, E."  
15   66  "Sheldrick, G.M."  
15   67  "Bolsterli, J.J."  
15   68  "Kallen, J."  
15   69  "Traber, R."  
15   70  "Walkinshaw, M.D."  
16   71  "Husak, M."  
16   72  "Kratochvil, B."  
16   73  "Jegorov, A."  
16   74  "Mat'ha, V."  
16   75  "Stuchlik, M."  
16   76  "Andrysek, T."  
17   77  "Husak, M."  
17   78  "Kratochvil, B."  
17   79  "Buchta, M."  
17   80  "Cvak, L."  
17   81  "Jegorov, A."  
18   82  "Kratochvil, B."  
18   83  "Jegorov, A."  
18   84  "Pakhomova, S."  
18   85  "Husak, M."  
18   86  "Bulej, P."  
18   87  "Cvak, L."  
18   88  "Sedmera, P."  
18   89  "Havlicek, V."  
19   90  "Jegorov, A."  
19   91  "Cvak, L."  
19   92  "Husek, A."  
19   93  "Simek, P."  
19   94  "Heydova, A."  
19   95  "Ondracek, J."  
19   96  "Pakhomova, S."  
19   97  "Husak, M."  
19   98  "Kratochvil, B."  
19   99  "Sedmera, P."  
19  100  "Havlicek, V."  
20  101  "Husak, M."  
20  102  "Kratochvil, B."  
20  103  "Cisarova, I."  
20  104  "Jegorov, A."  
21  105  "Jegorov, A."  
21  106  "Pakhomova, S."  
21  107  "Husak, M."  
21  108  "Kratochvil, B."  
21  109  "Zak, Z."  
21  110  "Cvak, L."  
21  111  "Buchta, M."  
22  112  "Potter, B."  
22  113  "Palmer, R.A."  
22  114  "Withnall, R."  
22  115  "Jenkins, T.C."  
22  116  "Chowdhry, B.Z."  
23  117  "Jegorov, A."  
23  118  "Husak, M."  
23  119  "Kratochvil, B."  
23  120  "Cisarova, I."  
24  121  "Libster, D."  
24  122  "Aserin, A."  
24  123  "Amar-Yuli, I."  
24  124  "Mishraki, T."  
24  125  "Domovich-Eisenberg, Y."  
24  126  "Livnah, O."  
24  127  "Garti, N."  
25  128  "Johnas, S.K."  
25  129  "Dittrich, B."  
25  130  "Meents, A."  
25  131  "Messerschmidt, M."  
25  132  "Weckert, E.F."  
#
loop_
_pdbx_family_prd_audit.family_prd_id
_pdbx_family_prd_audit.date
_pdbx_family_prd_audit.processing_site
_pdbx_family_prd_audit.action_type
FAM_000060	2012-02-08	RCSB	"Create family"	
FAM_000060	2013-10-16	RCSB	"Initial release"	
#
