2024-10-16 REL PDBj PDBj PDBj 2019-12-26 2020-04-01 2020-04-01 2024-10-16 Ministry of Science and Technology (MoST, China) 2018YFA0507000 China Ministry of Science and Technology (MoST, China) 2017YFA0504703 China National Science Foundation (NSF, China) 31825010 China National Science Foundation (NSF, China) 81525024 China National Science Foundation (NSF, China) 31830020 China Chinese Academy of Sciences QYZDB-SSW-SMC024 China Chinese Academy of Sciences QYZDB-SSW-SMC054 China Ministry of Science and Technology (MoST, China) 2018ZX09711002 China Cryo-EM structure of the human glucagon receptor in complex with Gi1 Qiao A Han S glucagon receptor, GPCR, Gi1 protein, SIGNALING PROTEIN Qiao A Han S Li X Li Z Zhao P Dai A Chang R Tai L Tan Q Chu X Ma L Thorsen TS Reedtz-Runge S Yang D Wang MW Sexton PM Wootten D Sun F Zhao Q Wu B Structural basis of Gsand Girecognition by the human glucagon receptor. Science US 367 1346 1352 2020 32193322 doi:10.1126/science.aaz5346 1095-9203 0038 SCIEAS 6lml FULLOVERLAP Complex of glucagon receptor bound to glucagon, Gi1 protein and antibody Complex of glucagon receptor bound to glucagon, Gi1 protein and antibody 0 1 2 3 4 5 6 Homo sapiens Guanine nucleotide-binding protein G(i) subunit alpha-1 Homo sapiens 0.040414046999999995 1 unidentified baculovirus LEVO MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKNTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGAQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM NRMHASMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY THFTCSTDTKNVQFVFDAVTDVIIKNNLKDCGLF P63096 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Homo sapiens 0.038744371 1 unidentified baculovirus LEVO MHHHHHHGSLLQSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRL LVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCC RFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLA GHDNRVSCLGVTDDGMAVATGSWDSFLKIWN P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Homo sapiens 0.007861143 1 unidentified baculovirus LEVO MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL P59768 scFv16 Mus musculus 0.026337307 1 unidentified baculovirus LEVO DVQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAPEKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLF LQMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSSGGGGSGGGGSGGGGSDIVMTQATSSVPVTPGESVSISCR SSKSLLHSNGNTYLYWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTISRLEAEDVGVYYCMQHLEYPLTFG AGTKLEL Glucagon Homo sapiens 0.003486781 1 LEVO HSQGTFTSDYSKYLDSRRAQDFVQWLMNT P01275 Glucagon receptor Homo sapiens 0.04857141 1 unidentified baculovirus LEVO QVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQW VRGPRGQPWRDASQCQMDGREIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVL KASSVLVIDGLLRWRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSL YLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFR LAKSTLTLIPLLGVHEVVFMFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWE ERNTSNGSGSEDQVDPRLIDGK P47871 singleParticle particle 7.5 ETHANE FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 GATAN K2 SUMMIT (4k x 4k) 1.875 1 5YQZ C1 3.9 FSC 0.143 CUT-OFF 312974 ANGULAR RECONSTITUTION ANGULAR RECONSTITUTION emd_0918.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 209.92 209.92 209.92 90.0 90.0 90.0 X Y Z -0.04249663 0.060105223 -0.0000054543434 0.002095241 0.82 0.82 0.82 0.012 AUTHOR emd_0918_msk_1.map