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        <title>Cryo-EM structure of human IgM-Fc in complex with the J chain and the ectodomain of pIgR</title>
        <authors_list>
            <author>Li Y</author>
            <author>Wang G</author>
        </authors_list>
        <keywords>immunoglobulin, pentamer, transcytosis, secreted, IMMUNE SYSTEM</keywords>
    </admin>
    <crossreferences>
        <citation_list>
            <primary_citation>
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                    <author ORCID="0000-0001-7550-0710" order="1">Li Y</author>
                    <author ORCID="0000-0002-2100-5439" order="2">Wang G</author>
                    <author ORCID="0000-0001-8601-5171" order="3">Li N</author>
                    <author ORCID="0000-0002-4490-3995" order="4">Wang Y</author>
                    <author ORCID="0000-0001-7020-2044" order="5">Zhu Q</author>
                    <author order="6">Chu H</author>
                    <author order="7">Wu W</author>
                    <author ORCID="0000-0002-8139-5758" order="8">Tan Y</author>
                    <author order="9">Yu F</author>
                    <author order="10">Su XD</author>
                    <author order="11">Gao N</author>
                    <author ORCID="0000-0003-1822-1701" order="12">Xiao J</author>
                    <title>Structural insights into immunoglobulin M.</title>
                    <journal_abbreviation>Science</journal_abbreviation>
                    <country>US</country>
                    <volume>367</volume>
                    <first_page>1014</first_page>
                    <last_page>1017</last_page>
                    <year>2020</year>
                    <external_references type="PUBMED">32029689</external_references>
                    <external_references type="DOI">doi:10.1126/science.aaz5425</external_references>
                    <external_references type="ISSN">1095-9203</external_references>
                    <external_references type="CSD">0038</external_references>
                    <external_references type="ASTM">SCIEAS</external_references>
                </journal_citation>
            </primary_citation>
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    </crossreferences>
    <sample>
        <name>Ternary complex of IgM-Fc with the J chain and pIgR/SC</name>
        <supramolecule_list>
            <complex_supramolecule supramolecule_id="1">
                <name>Ternary complex of IgM-Fc with the J chain and pIgR/SC</name>
                <parent>0</parent>
                <macromolecule_list>
                    <macromolecule>
                        <macromolecule_id>3</macromolecule_id>
                    </macromolecule>
                </macromolecule_list>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
            </complex_supramolecule>
        </supramolecule_list>
        <macromolecule_list>
            <protein_or_peptide macromolecule_id="1">
                <name>Immunoglobulin heavy constant mu</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.041875766</theoretical>
                </molecular_weight>
                <details>N-ACETYL-D-GLUCOSAMINE</details>
                <number_of_copies>10</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
                </recombinant_expression>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>ASAWSHPQFEKGGGSGGGSGGSAWSHPQFEKIDTTIAELPPKVSVFVPPRDGFFGNPRKSKLICQATGFSPRQIQVSWLR
EGKQVGSGVTTDQVQAEAKESGPTTYKVTSTLTIKESDWLGQSMFTCRVDHRGLTFQQNASSMCVPDQDTAIRVFAIPPS
FASIFLTKSTKLTCLVTDLTTYDSVTISWTRQNGEAVKTHTNISESHPNATFSAVGEASICEDDWNSGERFTCTVTHTDL
PSPLKQTISRPKGVALHRPDVYLLPPAREQLNLRESATITCLVTGFSPADVFVQWMQRGQPLSPEKYVTSAPMPEPQAPG
RYFAHSILTVSEEEWNTGETYTCVVAHEALPNRVTERTVDKSTGKPTLYNVSLVMSDTAGTCY</string>
                    <external_references type="UNIPROTKB">P01871</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="2">
                <name>Immunoglobulin J chain</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
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                    <theoretical units="MDa">0.015483328999999999</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
                </recombinant_expression>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>EDERIVLVDNKCKCARITSRIIRSSEDPNEDIVERNIRIIVPLNNRENISDPTSPLRTRFVYHLSDLCKKCDPTEVELDN
QIVTATQSNICDEDSATETCYTYDRNKCYTAVVPLVYGGETKMVETALTPDACYPD</string>
                    <external_references type="UNIPROTKB">P01591</external_references>
                </sequence>
            </protein_or_peptide>
            <protein_or_peptide macromolecule_id="3">
                <name>Polymeric immunoglobulin receptor</name>
                <natural_source database="NCBI">
                    <organism ncbi="9606">Homo sapiens</organism>
                </natural_source>
                <molecular_weight>
                    <theoretical units="MDa">0.061371875</theoretical>
                </molecular_weight>
                <number_of_copies>1</number_of_copies>
                <recombinant_expression database="NCBI">
                    <recombinant_organism ncbi="9606">Homo sapiens</recombinant_organism>
                </recombinant_expression>
                <enantiomer>LEVO</enantiomer>
                <sequence>
                    <string>KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIA
QLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVID
SSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCA
LGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSP
IQAWQLFVNEESTIPRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEE
PGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKW
NNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERHHHHHHHH</string>
                    <external_references type="UNIPROTKB">P01833</external_references>
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            </protein_or_peptide>
            <ligand macromolecule_id="5">
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                </molecular_weight>
                <number_of_copies>10</number_of_copies>
                <formula>NAG</formula>
            </ligand>
        </macromolecule_list>
    </sample>
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