2019-05-08 REL RCSB RCSB RCSB 2019-02-16 2019-03-13 2019-05-01 2019-05-08 Cryo-EM 3D map of human ATP-citrate lyase N-terminal segment in complex with inhibitor NDI-091143 Wei J Tong L Wei J Leit S Kuai J Therrien E Rafi S Harwood Jr HJ DeLaBarre B Tong L An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature UK 568 566 570 2019 30944472 doi:10.1038/s41586-019-1094-6 1476-4687 0006 NATUAS EMD-0567 other EM volume
Same protein-inhibitor complex, holoeyzme
 EMD-0568 associated EM volume protein-inhibitor complex protein-inhibitor complex 0 1 Homo sapiens Escherichia coli BL21 STAR singleParticle particle 4.7 7.5 20.0 Tris-HCl Tris-HCl 300.0 NaCl Sodium chloride 2.0 DTT Dithiothreitol ETHANE 100 295 FEI VITROBOT MARK II
FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD FIELD EMISSION GUN 300 2.7 -0.0008 -0.002 130000. FEI TITAN KRIOS AUTOGRID HOLDER NITROGEN GATAN K2 SUMMIT (4k x 4k) COUNTING 2803 10.0 71.0 1 250156 CTFFIND 4.1 C2 4.11 FSC 0.143 CUT-OFF RELION 3.0-beta-2 63657 MAXIMUM LIKELIHOOD RELION 3.0-beta-2 MAXIMUM LIKELIHOOD RELION 3.0-beta-2 RELION 3.0-beta-2 emd_0568.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 271.488 271.488 271.488 90.0 90.0 90.0 X Y Z -0.08003193 0.12672888 0.0001709734 0.002984444 1.0605 1.0605 1.0605 0.027 AUTHOR em-volume_P1 AB INITIO MODEL emd_0568_msk_1.map emd_0568_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 271.488 271.488 271.488 90.0 90.0 90.0 X Y Z -0.023051174 0.059927635 0.0000060361263 0.0027655447 1.0605 1.0605 1.0605 AUTHOR em-half-volume_P2 emd_0568_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 256 256 256 0 0 0 256 256 256 271.488 271.488 271.488 90.0 90.0 90.0 X Y Z -0.024975892 0.052935466 0.000003996782 0.0027509334 1.0605 1.0605 1.0605 AUTHOR em-half-volume_P1