2023-07-05 OBS RCSB RCSB RCSB 2023-01-24 2023-02-22 2023-02-22 2023-07-05 2023-07-05 National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) United States TRPV2 with CBD and PI lipid Tan X Swartz KJ Transport protein, MEMBRANE PROTEIN Gochman A Tan X Bae C Chen H Swartz KJ Jara-Oseguera A Cannabidiol sensitizes TRPV2 channels to activation by 2-APB. Biorxiv US 2023 36747846 doi:10.1101/2023.01.27.525817 2692-8205 EMD-29532 associated EM volume
TRPV2 with CBD and PI lipid
 8fxg FULLOVERLAP Trpv2 with CBD ligand Trpv2 with CBD ligand 0 1 Rattus norvegicus Transient receptor potential cation channel subfamily V member 2 Rattus norvegicus 0.086798891 4 Homo sapiens LEVO MTSASSPPAFRLETSDGDEEGNAEVNKGKQEPPPMESPFQREDRNSSPQIKVNLNFIKRPPKNTSAPSQQEPDRFDRDRL FSVVSRGVPEELTGLLEYLRWNSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACIMPLLQIDKDSGNPKLLVNAQCTDE FYQGHSALHIAIEKRSLQCVKLLVENGADVHLRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLE ATDSLGNTVLHALVMIADNSPENSALVIHMYDGLLQMGARLCPTVQLEEISNHQGLTPLKLAAKEGKIEIFRHILQREFS GPYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPNRHRMVVLEPLNKLLQEKWDRLVSRFFFNFACY LVYMFIFTVVAYHQPSLDQPAIPSSKATFGESMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLLQA LLTVLSQVLRFMETEWYLPLLVLSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSR EARSPKAPEDNNSTVTEQPTVGQEEEPAPYRSILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNM LIALMSETVNHVADNSWSIWKLQKAISVLEMENGYWWCRRKKHREGRLLKVGTRGDGTPDERWCFRVEEVNWAAWEKTLP TLSEDPSGPGITGNKKNPTSKPGKNSASEEDHLPLQVLQSP cannabidiol 0.000314462 8 P0T (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate 0.000600633 4 XJ7 SODIUM ION 2.299e-05 1 NA water 1.8015e-05 4 HOH singleParticle particle 7.5 ETHANE 100 FEI VITROBOT MARK IV FEI TITAN KRIOS FLOOD BEAM BRIGHT FIELD TUNGSTEN HAIRPIN 300 0.8 1.6 GATAN K3 BIOQUANTUM (6k x 4k) 52.0 1 6U84 3.44 FSC 0.143 CUT-OFF 43071 MAXIMUM LIKELIHOOD MAXIMUM LIKELIHOOD emd_29532.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 258.0 258.0 258.0 90.0 90.0 90.0 X Y Z -0.026880195 0.053981666 -0.000004889594 0.0027055154 0.86 0.86 0.86 0.0113 AUTHOR RIGID BODY FIT emd_29532_half_map_1.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 258.0 258.0 258.0 90.0 90.0 90.0 X Y Z -0.022703579 0.042675734 -0.00000093313014 0.002739753 0.86 0.86 0.86 AUTHOR emd_29532_half_map_2.map.gz 1 IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) 300 300 300 0 0 0 300 300 300 258.0 258.0 258.0 90.0 90.0 90.0 X Y Z -0.027172519 0.042556908 -0.000007932803 0.0027360641 0.86 0.86 0.86 AUTHOR