data_PRD_000006
# 
_pdbx_reference_molecule.prd_id                       PRD_000006 
_pdbx_reference_molecule.name                         "8-Fluoro-Actinomycin D" 
_pdbx_reference_molecule.represent_as                 polymer 
_pdbx_reference_molecule.type                         Polypeptide 
_pdbx_reference_molecule.type_evidence_code           ? 
_pdbx_reference_molecule.class                        Antibiotic 
_pdbx_reference_molecule.class_evidence_code          ? 
_pdbx_reference_molecule.formula                      "C62 H85 F N12 O16" 
_pdbx_reference_molecule.formula_weight               1273.49 
_pdbx_reference_molecule.chem_comp_id                 ? 
_pdbx_reference_molecule.release_status               REL 
_pdbx_reference_molecule.replaces                     ? 
_pdbx_reference_molecule.replaced_by                  ? 
_pdbx_reference_molecule.compound_details             
;ACTINOMYCIN D IS A BICYCLIC PEPTIDE, A MEMBER OF THE
ACTINOMYCIN FAMILY.
HERE, ACTINOMYCIN D IS REPRESENTED BY THE SEQUENCE (SEQRES)
;
_pdbx_reference_molecule.description                  
;ACTINOMYCIN D CONSISTS OF TWO PENTAMER
RINGS LINKED BY THE CHROMOPHORE (PXF)
THE CHROMOPHORE PXF IS A MODIFIED PXZ WITH
C-F REPLACING C-H IN POSITION 8 OF THE
PHENOXAZONE RING.
;
_pdbx_reference_molecule.representative_PDB_id_code   316d 
# 
_pdbx_reference_entity_list.prd_id          PRD_000006 
_pdbx_reference_entity_list.ref_entity_id   1 
_pdbx_reference_entity_list.component_id    1 
_pdbx_reference_entity_list.type            polymer 
_pdbx_reference_entity_list.details         "PEPTIDE LIKE SEQUENCE RESIDUES 1 TO 11" 
# 
loop_
_pdbx_reference_entity_poly_link.prd_id 
_pdbx_reference_entity_poly_link.ref_entity_id 
_pdbx_reference_entity_poly_link.link_id 
_pdbx_reference_entity_poly_link.atom_id_1 
_pdbx_reference_entity_poly_link.comp_id_1 
_pdbx_reference_entity_poly_link.entity_seq_num_1 
_pdbx_reference_entity_poly_link.atom_id_2 
_pdbx_reference_entity_poly_link.comp_id_2 
_pdbx_reference_entity_poly_link.entity_seq_num_2 
_pdbx_reference_entity_poly_link.value_order 
_pdbx_reference_entity_poly_link.component_id 
_pdbx_reference_entity_poly_link.details 
_pdbx_reference_entity_poly_link.insert_code_1 
_pdbx_reference_entity_poly_link.insert_code_2 
PRD_000006 1 1  C     THR 1  N  DVA 2  sing 1 ? ? ? 
PRD_000006 1 2  OG1   THR 1  C  MVA 5  sing 1 ? ? ? 
PRD_000006 1 3  N     THR 1  C0 PXF 6  sing 1 ? ? ? 
PRD_000006 1 4  C     DVA 2  N  PRO 3  sing 1 ? ? ? 
PRD_000006 1 5  C     PRO 3  N  SAR 4  sing 1 ? ? ? 
PRD_000006 1 6  C     SAR 4  N  MVA 5  sing 1 ? ? ? 
PRD_000006 1 7  "C0'" PXF 6  N  THR 7  sing 1 ? ? ? 
PRD_000006 1 8  C     THR 7  N  DVA 8  sing 1 ? ? ? 
PRD_000006 1 9  OG1   THR 7  C  MVA 11 sing 1 ? ? ? 
PRD_000006 1 10 C     DVA 8  N  PRO 9  sing 1 ? ? ? 
PRD_000006 1 11 C     PRO 9  N  SAR 10 sing 1 ? ? ? 
PRD_000006 1 12 C     SAR 10 N  MVA 11 sing 1 ? ? ? 
# 
_pdbx_reference_entity_poly.prd_id          PRD_000006 
_pdbx_reference_entity_poly.ref_entity_id   1 
_pdbx_reference_entity_poly.db_code         ? 
_pdbx_reference_entity_poly.db_name         ? 
_pdbx_reference_entity_poly.type            peptide-like 
# 
_pdbx_reference_entity_sequence.prd_id          PRD_000006 
_pdbx_reference_entity_sequence.ref_entity_id   1 
_pdbx_reference_entity_sequence.type            peptide-like 
_pdbx_reference_entity_sequence.NRP_flag        Y 
# 
loop_
_pdbx_reference_entity_poly_seq.prd_id 
_pdbx_reference_entity_poly_seq.ref_entity_id 
_pdbx_reference_entity_poly_seq.num 
_pdbx_reference_entity_poly_seq.mon_id 
_pdbx_reference_entity_poly_seq.parent_mon_id 
_pdbx_reference_entity_poly_seq.hetero 
_pdbx_reference_entity_poly_seq.observed 
PRD_000006 1 1  THR THR N Y 
PRD_000006 1 2  DVA VAL N Y 
PRD_000006 1 3  PRO PRO N Y 
PRD_000006 1 4  SAR GLY N Y 
PRD_000006 1 5  MVA VAL N Y 
PRD_000006 1 6  PXF ?   N Y 
PRD_000006 1 7  THR THR N Y 
PRD_000006 1 8  DVA VAL N Y 
PRD_000006 1 9  PRO PRO N Y 
PRD_000006 1 10 SAR GLY N Y 
PRD_000006 1 11 MVA VAL N Y 
# 
_pdbx_reference_entity_src_nat.prd_id                PRD_000006 
_pdbx_reference_entity_src_nat.ref_entity_id         1 
_pdbx_reference_entity_src_nat.ordinal               1 
_pdbx_reference_entity_src_nat.taxid                 ? 
_pdbx_reference_entity_src_nat.organism_scientific   Semi-synthetic 
_pdbx_reference_entity_src_nat.source                ? 
_pdbx_reference_entity_src_nat.db_code               ? 
_pdbx_reference_entity_src_nat.db_name               ? 
_pdbx_reference_entity_src_nat.strain                ? 
# 
loop_
_pdbx_prd_audit.prd_id 
_pdbx_prd_audit.date 
_pdbx_prd_audit.processing_site 
_pdbx_prd_audit.action_type 
PRD_000006 2012-02-01 RCSB "Create molecule"    
PRD_000006 2012-07-09 PDBE "Other modification" 
PRD_000006 2012-12-12 RCSB "Initial release"    
PRD_000006 2013-06-03 RCSB "Other modification" 
PRD_000006 2017-05-04 RCSB "Other modification" 
PRD_000006 2023-09-20 PDBE "Modify audit"       
PRD_000006 2023-11-03 PDBE "Other modification" 
# 
